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Table of Contents

February 2020 | Volume 3, No. 2

Research Articles

  • CLIC4 and CLIC1 bridge plasma membrane and cortical actin network for a successful cytokinesis
    Open Access
    CLIC4 and CLIC1 bridge plasma membrane and cortical actin network for a successful cytokinesis

    Zeynep Cansu Uretmen Kagiali, Nazan Saner, Mehmet Akdag, Erdem Sanal, Beste Senem Degirmenci, Gurkan Mollaoglu, Nurhan Ozlu

    Zeynep Cansu Uretmen Kagiali ... Nurhan Ozlu

    Published 26 December 2019

    CLIC members are required for the progression of cytokinesis by coupling the plasma membrane and cortical actin network at the cleavage furrow and polar cortex.

  • TRAP1 chaperone protein mutations and autoinflammation
    Open Access
    TRAP1 chaperone protein mutations and autoinflammation

    Ariane SI Standing, Ying Hong, Coro Paisan-Ruiz, Ebun Omoyinmi, Alan Medlar, Horia Stanescu, Robert Kleta, Dorota Rowcenzio, Philip Hawkins, Helen Lachmann, Michael F McDermott, Despina Eleftheriou, Nigel Klein, Paul A Brogan

    Ariane SI Standing ... Paul A Brogan

    Published 27 December 2019

    This study identifies patients with autoinflammation and mutations affecting the mitochondrial/ER protein chaperone TRAP1, either alone or digenic, with MEFV mutation possibly synergizing to produce severe disease. TRAP1 mutations lead to increased mitochondrial reactive oxygen species and may contribute to autoinflammation.

  • Laminin is the ECM niche for trophoblast stem cells
    Open Access
    Laminin is the ECM niche for trophoblast stem cells

    Daiji Kiyozumi, Itsuko Nakano, Ryoko Sato-Nishiuchi, Satoshi Tanaka, Kiyotoshi Sekiguchi

    Daiji Kiyozumi ... Kiyotoshi Sekiguchi

    Published 14 January 2020

    Laminin functions as an ECM niche factor for trophoblast stem cells and secures trophoblast stem cell expansion through its interactions with integrin.

  • Virus-induced transposable element expression up-regulation in human and mouse host cells
    Open Access
    Virus-induced transposable element expression up-regulation in human and mouse host cells

    Marissa G Macchietto, Ryan A Langlois, Steven S Shen

    Marissa G Macchietto ... Steven S Shen

    Published 21 January 2020

    Genome-wide transposon expression up-regulation in host cells regardless of virus, species, and host cell tissue types occurs early during viral infection and likely contributes to promoting the host innate immune response.

  • Altering microtubule dynamics is synergistically toxic with spindle assembly checkpoint inhibition
    Open Access
    Altering microtubule dynamics is synergistically toxic with spindle assembly checkpoint inhibition

    Klaske M Schukken, Yu-Chih Lin, Petra L Bakker, Michael Schubert, Stephanie F Preuss, Judith E Simon, Hilda van den Bos, Zuzana Storchova, Maria Colomé-Tatché, Holger Bastians, Diana CJ Spierings, Floris Foijer

    Klaske M Schukken ... Floris Foijer

    Published 24 January 2020

    Chromosomal instability (CIN) is a hallmark feature of cancer cells. In this study, Schukken and colleagues screen for compounds that selectively target CIN cells and identify an inhibitor of Src kinase to be selectively toxic for CIN cells.

  • Constitutive CD8 expression drives innate CD8<sup>+</sup> T-cell differentiation via induction of iNKT2 cells
    Open Access
    Constitutive CD8 expression drives innate CD8+ T-cell differentiation via induction of iNKT2 cells

    Satoshi Kojo, Michiko Ohno-Oishi, Hisashi Wada, Sebastian Nieke, Wooseok Seo, Sawako Muroi, Ichiro Taniuchi

    Satoshi Kojo ... Ichiro Taniuchi

    Published 24 January 2020

    Constitutive CD8 expression induces differentiation of innate memory-like CD8+ thymocytes in both cell-intrinsic and cell-extrinsic manner, the latter being accomplished by an increase in the iNKT2 subset.

  • Oxidised metabolites of the omega-6 fatty acid linoleic acid activate dFOXO
    Open Access
    Oxidised metabolites of the omega-6 fatty acid linoleic acid activate dFOXO

    So Yeon Kwon, Karen Massey, Mark A Watson, Tayab Hussain, Giacomo Volpe, Christopher D Buckley, Anna Nicolaou, Paul Badenhorst

    So Yeon Kwon ... Paul Badenhorst

    Published 28 January 2020

    Oxidised omega-6 fatty acids activate the FOXO transducers of the Insulin signaling pathway potentially linking changes in dietary fatty acid balance and proinflammatory states with insulin resistance.

  • Retrograde trafficking of Argonaute 2 acts as a rate-limiting step for de novo miRNP formation on endoplasmic reticulum–attached polysomes in mammalian cells
    Open Access
    Retrograde trafficking of Argonaute 2 acts as a rate-limiting step for de novo miRNP formation on endoplasmic reticulum–attached polysomes in mammalian cells

    Mainak Bose, Susanta Chatterjee, Yogaditya Chakrabarty, Bahnisikha Barman, Suvendra N Bhattacharyya

    Mainak Bose ... Suvendra N Bhattacharyya

    Published 3 February 2020

    Intracellular trafficking of Argonaute 2 controls de novo miRNP formation on endoplasmic reticulum–attached polysomes in mammalian cells.

  • Essential role of the <em>Crk</em> family-dosage in DiGeorge-like anomaly and metabolic homeostasis
    Open Access
    Essential role of the Crk family-dosage in DiGeorge-like anomaly and metabolic homeostasis

    Akira Imamoto, Sewon Ki, Leiming Li, Kazunari Iwamoto, Venkat Maruthamuthu, John Devany, Ocean Lu, Tomomi Kanazawa, Suxiang Zhang, Takuji Yamada, Akiyoshi Hirayama, Shinji Fukuda, Yutaka Suzuki, Mariko Okada

    Akira Imamoto ... Mariko Okada

    Published 10 February 2020

    This study presents evidence that CRK/CRKL and TBX1 may share pathways that participate in organogenesis affected in DiGeorge syndrome (22q11.2DS) via global control of gene expression and metabolism

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Volume 3, No. 2
February 2020
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