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Research Articles
CLIC4 and CLIC1 bridge plasma membrane and cortical actin network for a successful cytokinesisCLIC members are required for the progression of cytokinesis by coupling the plasma membrane and cortical actin network at the cleavage furrow and polar cortex.
TRAP1 chaperone protein mutations and autoinflammationThis study identifies patients with autoinflammation and mutations affecting the mitochondrial/ER protein chaperone TRAP1, either alone or digenic, with MEFV mutation possibly synergizing to produce severe disease. TRAP1 mutations lead to increased mitochondrial reactive oxygen species and may contribute to autoinflammation.
Laminin is the ECM niche for trophoblast stem cellsLaminin functions as an ECM niche factor for trophoblast stem cells and secures trophoblast stem cell expansion through its interactions with integrin.
Virus-induced transposable element expression up-regulation in human and mouse host cellsGenome-wide transposon expression up-regulation in host cells regardless of virus, species, and host cell tissue types occurs early during viral infection and likely contributes to promoting the host innate immune response.
Altering microtubule dynamics is synergistically toxic with spindle assembly checkpoint inhibitionChromosomal instability (CIN) is a hallmark feature of cancer cells. In this study, Schukken and colleagues screen for compounds that selectively target CIN cells and identify an inhibitor of Src kinase to be selectively toxic for CIN cells.
Constitutive CD8 expression drives innate CD8+ T-cell differentiation via induction of iNKT2 cellsConstitutive CD8 expression induces differentiation of innate memory-like CD8+ thymocytes in both cell-intrinsic and cell-extrinsic manner, the latter being accomplished by an increase in the iNKT2 subset.
Oxidised metabolites of the omega-6 fatty acid linoleic acid activate dFOXOOxidised omega-6 fatty acids activate the FOXO transducers of the Insulin signaling pathway potentially linking changes in dietary fatty acid balance and proinflammatory states with insulin resistance.
Retrograde trafficking of Argonaute 2 acts as a rate-limiting step for de novo miRNP formation on endoplasmic reticulum–attached polysomes in mammalian cellsIntracellular trafficking of Argonaute 2 controls de novo miRNP formation on endoplasmic reticulum–attached polysomes in mammalian cells.
Essential role of the Crk family-dosage in DiGeorge-like anomaly and metabolic homeostasisThis study presents evidence that CRK/CRKL and TBX1 may share pathways that participate in organogenesis affected in DiGeorge syndrome (22q11.2DS) via global control of gene expression and metabolism
