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About the Cover

December 2020 | Volume 3, No. 12

Research Articles

  • Fungal mycelia and bacterial thiamine establish a mutualistic growth mechanism
    Open Access
    Fungal mycelia and bacterial thiamine establish a mutualistic growth mechanism

    Gayan Abeysinghe, Momoka Kuchira, Gamon Kudo, Shunsuke Masuo, Akihiro Ninomiya, Kohei Takahashi, Andrew S Utada, Daisuke Hagiwara, Nobuhiko Nomura, Naoki Takaya, Nozomu Obana, Norio Takeshita

    Gayan Abeysinghe ... Norio Takeshita

    Published 22 September 2020

    Bacterial cells travel along fungal highway and pay thiamine as a toll to the fungus. Simultaneous spatial and metabolic interactions in communicating bacterial and fungal species establish a mutualism that facilitates them to obtain an environmental niche and nutrient.

  • Mps2 links Csm4 and Mps3 to form a telomere-associated LINC complex in budding yeast
    Open Access
    Mps2 links Csm4 and Mps3 to form a telomere-associated LINC complex in budding yeast

    Jinbo Fan, Hui Jin, Bailey A Koch, Hong-Guo Yu

    Jinbo Fan ... Hong-Guo Yu

    Published 23 September 2020

    The canonical LINC complex is composed of two different transmembrane proteins; this work reveals the heterotrimeric composition of the telomere-associated LINC complex in budding yeast.

  • Neurturin regulates the lung-resident macrophage inflammatory response to viral infection
    Open Access
    Neurturin regulates the lung-resident macrophage inflammatory response to viral infection

    Emma Connolly, David J Morgan, Miriam Franklin, Angela Simpson, Rajesh Shah, Oliver J Brand, Christopher P Jagger, Joshua Casulli, Karishma Mohamed, Aleksander M Grabiec, Tracy Hussell

    Emma Connolly ... Tracy Hussell

    Published 5 October 2020

    The neurotrophic factor RET is induced in lung macrophages by viral triggers and activation via its ligand neurturin regulates matrix proteins and cytokines that shape the inflammatory response.

  • In vivo CRISPR/Cas9 knockout screen: TCEAL1 silencing enhances docetaxel efficacy in prostate cancer
    Open Access
    In vivo CRISPR/Cas9 knockout screen: TCEAL1 silencing enhances docetaxel efficacy in prostate cancer

    Linda K Rushworth, Victoria Harle, Peter Repiscak, William Clark, Robin Shaw, Holly Hall, Martin Bushell, Hing Y Leung, Rachana Patel

    Linda K Rushworth ... Rachana Patel

    Published 8 October 2020

    A whole genome in vivo CRISPR/Cas9 screen identifies TCEAL1 as a potential target to sensitise prostate cancer cells to docetaxel to improve the efficacy of chemotherapy.

  • A double role of the Gal80 N terminus in activation of transcription by Gal4p
    Open Access
    A double role of the Gal80 N terminus in activation of transcription by Gal4p

    Annekathrin Reinhardt-Tews, Rościsław Krutyhołowa, Christian Günzel, Constance Roehl, Sebastian Glatt, Karin D Breunig

    Annekathrin Reinhardt-Tews ... Karin D Breunig

    Published 9 October 2020

    Activation of gene expression by Gal4p in K. lactis requires an element in the N terminus of KlGal80p that mediates nuclear co-import of KlGal1p and galactokinase inhibition to support the co-inducer function of KlGal1p.

  • Role of opioid signaling in kidney damage during the development of salt-induced hypertension
    Open Access
    Role of opioid signaling in kidney damage during the development of salt-induced hypertension

    Daria Golosova, Oleg Palygin, Ruslan Bohovyk, Christine A Klemens, Vladislav Levchenko, Denisha R Spires, Elena Isaeva, Ashraf El-Meanawy, Alexander Staruschenko

    Daria Golosova ... Alexander Staruschenko

    Published 12 October 2020

    Stimulation of kappa opioid receptors modulates calcium influx via TRPC6 channels in podocytes, which ultimately compromises the integrity of the glomerular filtration barrier and promotes a marked worsening of blood pressure control and renal damage.

  • Incipient sympatric speciation in wild barley caused by geological-edaphic divergence
    Open Access
    Incipient sympatric speciation in wild barley caused by geological-edaphic divergence

    Kexin Li, Xifeng Ren, Xiaoying Song, Xiujuan Li, Yu Zhou, Eli Harlev, Dongfa Sun, Eviatar Nevo

    Kexin Li ... Eviatar Nevo

    Published 20 October 2020

    Sympatric speciation is still contentious but here based on genome-wide analysis; we show incipient sympatric speciation of an emerging new wild barley species from Hordeum spontaneum, the progenitor of all cultivated barleys at “Evolution Plateau” (EP), Upper Galilee, Israel.

  • Inhibition of a transcriptional repressor rescues hearing in a splicing factor–deficient mouse
    Open Access
    Inhibition of a transcriptional repressor rescues hearing in a splicing factor–deficient mouse

    Yoko Nakano, Susan Wiechert, Bernd Fritzsch, Botond Bánfi

    Yoko Nakano ... Botond Bánfi

    Published 21 October 2020

    The vital role of the splicing factor SRRM4 in vestibular and inner hair cells of the ear is inactivation of the gene repressor REST; however, in outer hair cells, SRRM4 is dispensable for REST inactivation, which SRRM3 accomplishes independently.

  • Brain is an endocrine organ through secretion and nuclear transfer of parathymosin
    Open Access
    Brain is an endocrine organ through secretion and nuclear transfer of parathymosin

    Bin Yu, Yizhe Tang, Dongsheng Cai

    Bin Yu ... Dongsheng Cai

    Published 21 October 2020

    The hypothalamus and brain neurons orchestrate the secretion and nuclear transfer of PTMS which is neuroprotective against aging-related disorders.

  • Myocardial infarction affects Cx43 content of extracellular vesicles secreted by cardiomyocytes
    Open Access
    Myocardial infarction affects Cx43 content of extracellular vesicles secreted by cardiomyocytes

    Tania Martins-Marques, Teresa Ribeiro-Rodrigues, Saskia C de Jager, Monica Zuzarte, Cátia Ferreira, Pedro Cruz, Liliana Reis, Rui Baptista, Lino Gonçalves, Joost PG Sluijter, Henrique Girao

    Tania Martins-Marques ... Henrique Girao

    Published 23 October 2020

    Ubiquitin signals the sorting of Cx43 into EVs, which is impaired during ischemia, resulting in decreased levels of Cx43 in cardiomyocyte-derived and circulating EVs from myocardial infarcted patients.

  • Chromosome instability induced by a single defined sister chromatid fusion
    Open Access
    Chromosome instability induced by a single defined sister chromatid fusion

    Katsushi Kagaya, Naoto Noma-Takayasu, Io Yamamoto, Sanki Tashiro, Fuyuki Ishikawa, Makoto T Hayashi

    Katsushi Kagaya ... Makoto T Hayashi

    Published 26 October 2020

    Newly developed Fusion Visualization (FuVis) system reveals a single Xp sister chromatid fusion induces micronuclei formation, acentric chromosome fragments, and cell cycle instabilities.

  • Spastin recovery in hereditary spastic paraplegia by preventing neddylation-dependent degradation
    Open Access
    Spastin recovery in hereditary spastic paraplegia by preventing neddylation-dependent degradation

    Francesca Sardina, Alessandra Pisciottani, Manuela Ferrara, Davide Valente, Marialuisa Casella, Marco Crescenzi, Angelo Peschiaroli, Carlo Casali, Silvia Soddu, Andrew J Grierson, Cinzia Rinaldo

    Francesca Sardina ... Cinzia Rinaldo

    Published 26 October 2020

    The balance between HIPK2-mediated phosphorylation and neddylation-dependent degradation controls spastin protein levels, revealing novel therapeutic targets for hereditary spastic paraplegia.

  • <em>Plasmodium</em> DEH is ER-localized and crucial for oocyst mitotic division during malaria transmission
    Open Access
    Plasmodium DEH is ER-localized and crucial for oocyst mitotic division during malaria transmission

    David S Guttery, Rajan Pandey, David JP Ferguson, Richard J Wall, Declan Brady, Dinesh Gupta, Anthony A Holder, Rita Tewari

    David S Guttery ... Rita Tewari

    Published 26 October 2020

    Plasmodium DEH localizes to the ER, with gene deletion resulting in degeneration of developing oocysts and complete ablation of sporogony in the mosquito midgut, blocking transmission.

  • Notch1 signaling determines the plasticity and function of fibroblasts in diabetic wounds
    Open Access
    Notch1 signaling determines the plasticity and function of fibroblasts in diabetic wounds

    Hongwei Shao, Yan Li, Irena Pastar, Min Xiao, Rochelle Prokupets, Sophia Liu, Kerstin Yu, Roberto I Vazquez-Padron, Marjana Tomic-Canic, Omaida C Velazquez, Zhao-Jun Liu

    Hongwei Shao ... Zhao-Jun Liu

    Published 27 October 2020

    Notch1 signaling determines the plasticity and function of fibroblasts in diabetic wounds and may serve as a potential target for therapeutic intervention in diabetic wound healing.

  • Aberrant autophagosome formation occurs upon small molecule inhibition of ULK1 kinase activity
    Open Access
    Aberrant autophagosome formation occurs upon small molecule inhibition of ULK1 kinase activity

    Maria Zachari, Marianna Longo, Ian G Ganley

    Maria Zachari ... Ian G Ganley

    Published 27 October 2020

    Pharmacological inhibition of ULK1 with multiple and distinct small molecules does not block autophagosome initiation but does impair autophagic flux.

  • <em>Leishmania</em>-infected macrophages release extracellular vesicles that can promote lesion development
    Open Access
    Leishmania-infected macrophages release extracellular vesicles that can promote lesion development

    Anna Gioseffi, Tim Hamerly, Kha Van, Naixin Zhang, Rhoel R Dinglasan, Phillip A Yates, Peter E Kima

    Anna Gioseffi ... Peter E Kima

    Published 29 October 2020

    Macrophages infected with Leishmania donovani release extracellular vesicles that are composed of parasite and host-derived molecules that have the potential to induce vascular changes in tissues.

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In this Issue

Volume 3, No. 12
December 2020
  • Table of Contents
  • Cover (PDF)
  • About the Cover
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