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Genome-wide R-loop analysis defines unique roles for DDX5, XRN2, and PRMT5 in DNA/RNA hybrid resolution

View ORCID ProfileOscar D Villarreal, Sofiane Y Mersaoui, Zhenbao Yu, Jean-Yves Masson, View ORCID ProfileStéphane Richard  Correspondence email
Oscar D Villarreal
1Segal Cancer Center, Lady Davis Institute for Medical Research and Gerald Bronfman Department of Oncology and Departments of Biochemistry, Human Genetics and Medicine, McGill University, Montréal, Canada
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  • ORCID record for Oscar D Villarreal
Sofiane Y Mersaoui
1Segal Cancer Center, Lady Davis Institute for Medical Research and Gerald Bronfman Department of Oncology and Departments of Biochemistry, Human Genetics and Medicine, McGill University, Montréal, Canada
2Genome Stability Laboratory, Centre Hospitalier Universitaire de Québec Research Center, Oncology Axis; Department of Molecular Biology, Medical Biochemistry and Pathology; Laval University Cancer Research Center, Québec City, Canada
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Zhenbao Yu
1Segal Cancer Center, Lady Davis Institute for Medical Research and Gerald Bronfman Department of Oncology and Departments of Biochemistry, Human Genetics and Medicine, McGill University, Montréal, Canada
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Jean-Yves Masson
2Genome Stability Laboratory, Centre Hospitalier Universitaire de Québec Research Center, Oncology Axis; Department of Molecular Biology, Medical Biochemistry and Pathology; Laval University Cancer Research Center, Québec City, Canada
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Stéphane Richard
1Segal Cancer Center, Lady Davis Institute for Medical Research and Gerald Bronfman Department of Oncology and Departments of Biochemistry, Human Genetics and Medicine, McGill University, Montréal, Canada
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  • ORCID record for Stéphane Richard
  • For correspondence: stephane.richard@mcgill.ca
Published 3 August 2020. DOI: 10.26508/lsa.202000762
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Article Information

vol. 3 no. 10 e202000762
DOI 
https://doi.org/10.26508/lsa.202000762
PubMed 
32747416

Published By 
Life Science Alliance
Online ISSN 
2575-1077
History 
  • Received May 1, 2020
  • Revision received July 23, 2020
  • Accepted July 24, 2020
  • Published online August 3, 2020.

Copyright & Usage 
© 2020 Villarreal et al. This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).

Author Information

  1. Oscar D Villarreal1,*,
  2. Sofiane Y Mersaoui1,2,*,
  3. Zhenbao Yu1,*,
  4. Jean-Yves Masson2 and
  5. Stéphane Richard1⇑
  1. 1Segal Cancer Center, Lady Davis Institute for Medical Research and Gerald Bronfman Department of Oncology and Departments of Biochemistry, Human Genetics and Medicine, McGill University, Montréal, Canada
  2. 2Genome Stability Laboratory, Centre Hospitalier Universitaire de Québec Research Center, Oncology Axis; Department of Molecular Biology, Medical Biochemistry and Pathology; Laval University Cancer Research Center, Québec City, Canada
  1. Correspondence: stephane.richard{at}mcgill.ca
  1. ↵* Oscar D Villarreal, Sofiane Y Mersaoui, and Zhenbao Yu contributed equally to this work

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Funding

  • FDN-154303
    S Richard
  • FDN-388879
    J-Y Masson
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Genome-wide R-loop analysis defines unique roles for DDX5, XRN2, and PRMT5 in DNA/RNA hybrid resolution
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DRIP-seq analysis of siDDX5, siXRN2 and siPRMT5 U2OS cells
Oscar D Villarreal, Sofiane Y Mersaoui, Zhenbao Yu, Jean-Yves Masson, Stéphane Richard
Life Science Alliance Aug 2020, 3 (10) e202000762; DOI: 10.26508/lsa.202000762

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DRIP-seq analysis of siDDX5, siXRN2 and siPRMT5 U2OS cells
Oscar D Villarreal, Sofiane Y Mersaoui, Zhenbao Yu, Jean-Yves Masson, Stéphane Richard
Life Science Alliance Aug 2020, 3 (10) e202000762; DOI: 10.26508/lsa.202000762
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Volume 3, No. 10
October 2020
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