Evolutionary divergence reveals the molecular basis of EMRE dependence of the human MCU

Melissa JS MacEwen; Andrew L Markhard; Mert Bozbeyoglu; Forrest Bradford; Olga Goldberger; Vamsi K Mootha; Yasemin Sancak

doi:10.26508/lsa.202000718

Research Article

Open Access

Evolutionary divergence reveals the molecular basis of EMRE dependence of the human MCU

View ORCID ProfileMelissa JS MacEwen, Andrew L Markhard, Mert Bozbeyoglu, Forrest Bradford, Olga Goldberger, View ORCID ProfileVamsi K Mootha Correspondence email, View ORCID ProfileYasemin Sancak Correspondence email

Melissa JS MacEwen

1Department of Pharmacology, University of Washington, Seattle, WA, USA

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ORCID record for Melissa JS MacEwen

Andrew L Markhard

2Howard Hughes Medical Institute and Department of Molecular Biology, Massachusetts General Hospital, Boston, MA, USA

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Mert Bozbeyoglu

2Howard Hughes Medical Institute and Department of Molecular Biology, Massachusetts General Hospital, Boston, MA, USA

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Forrest Bradford

1Department of Pharmacology, University of Washington, Seattle, WA, USA

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Olga Goldberger

2Howard Hughes Medical Institute and Department of Molecular Biology, Massachusetts General Hospital, Boston, MA, USA

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Vamsi K Mootha

2Howard Hughes Medical Institute and Department of Molecular Biology, Massachusetts General Hospital, Boston, MA, USA

3Broad Institute, Cambridge, MA, USA

4Department of Systems Biology, Harvard Medical School, Boston, MA, USA

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For correspondence: vamsi@hms.harvard.edu

Yasemin Sancak

1Department of Pharmacology, University of Washington, Seattle, WA, USA

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ORCID record for Yasemin Sancak
For correspondence: sancak@uw.edu

Published 7 August 2020. DOI: 10.26508/lsa.202000718

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Molecular basis of EMRE dependence of the human MCU