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Table of Contents

October 2020 | Volume 3, No. 10

Research Articles

  • Profiles of histidine-rich glycoprotein associate with age and risk of all-cause mortality
    Open Access
    Profiles of histidine-rich glycoprotein associate with age and risk of all-cause mortality

    Mun-Gwan Hong, Tea Dodig-Crnković, Xu Chen, Kimi Drobin, Woojoo Lee, Yunzhang Wang, Fredrik Edfors, David Kotol, Cecilia Engel Thomas, Ronald Sjöberg, Jacob Odeberg, Anders Hamsten, Angela Silveira, Per Hall, Peter Nilsson, Yudi Pawitan, Mathias Uhlén, Nancy L Pedersen, Sara Hägg, Patrik KE Magnusson, Jochen M Schwenk

    Mun-Gwan Hong ... Jochen M Schwenk

    Published 31 July 2020

    Affinity-based proteomics assays identify particular profiles of the circulating histidine-rich glycoprotein to increase with age and elevated levels to indicate a higher risk of all-cause mortality.

  • Sam68 splicing regulation contributes to motor unit establishment in the postnatal skeletal muscle
    Open Access
    Sam68 splicing regulation contributes to motor unit establishment in the postnatal skeletal muscle

    Elisa De Paola, Laura Forcina, Laura Pelosi, Simona Pisu, Piergiorgio La Rosa, Eleonora Cesari, Carmine Nicoletti, Luca Madaro, Neri Mercatelli, Filippo Biamonte, Annalisa Nobili, Marcello D’Amelio, Marco De Bardi, Elisabetta Volpe, Daniela Caporossi, Claudio Sette, Antonio Musarò, Maria Paola Paronetto

    Elisa De Paola ... Maria Paola Paronetto

    Published 4 August 2020

    Sam68 ensures the establishment of neuromuscular junctions (NMJs) and motor unit integrity by orchestrating a neuronal splicing program.

  • Peptide-based quorum sensing systems in <em>Paenibacillus polymyxa</em>
    Open Access
    Peptide-based quorum sensing systems in Paenibacillus polymyxa

    Maya Voichek, Sandra Maaß, Tobias Kroniger, Dörte Becher, Rotem Sorek

    Maya Voichek ... Rotem Sorek

    Published 6 August 2020

    Discovery of conserved communication systems in the agriculturally important Paenibacillus bacteria. These systems are widespread, and some species encode more than 25 different peptide-receptor pairs.

  • Exploiting somatic piRNAs in <em>Bemisia tabac</em>i enables novel gene silencing through RNA feeding
    Open Access
    Exploiting somatic piRNAs in Bemisia tabaci enables novel gene silencing through RNA feeding

    Mosharrof Mondal, Judith K Brown, Alex Flynt

    Mosharrof Mondal ... Alex Flynt

    Published 6 August 2020

    RNAi usually relies on Dicer-produced siRNAs to induce gene silencing. In many arthropods, another type of RNAi is present in the soma—the piRNA pathway. This work finds exploiting this biology is a viable alternative for gene knockdown.

  • Evolutionary divergence reveals the molecular basis of EMRE dependence of the human MCU
    Open Access
    Evolutionary divergence reveals the molecular basis of EMRE dependence of the human MCU

    Melissa JS MacEwen, Andrew L Markhard, Mert Bozbeyoglu, Forrest Bradford, Olga Goldberger, Vamsi K Mootha, Yasemin Sancak

    Melissa JS MacEwen ... Yasemin Sancak

    Published 7 August 2020

    Using clues from evolution, chimeric proteins, and biochemical methods, this work identifies a new domain in mitochondrial calcium uniporter that determines its dependence on its binding partner EMRE.

  • The bacterial quorum sensing signal DSF hijacks <em>Arabidopsis thaliana</em> sterol biosynthesis to suppress plant innate immunity
    Open Access
    The bacterial quorum sensing signal DSF hijacks Arabidopsis thaliana sterol biosynthesis to suppress plant innate immunity

    Tuan Minh Tran, Zhiming Ma, Alexander Triebl, Sangeeta Nath, Yingying Cheng, Ben-Qiang Gong, Xiao Han, Junqi Wang, Jian-Feng Li, Markus R Wenk, Federico Torta, Satyajit Mayor, Liang Yang, Yansong Miao

    Tuan Minh Tran ... Yansong Miao

    Published 11 August 2020

    This study highlights that DSF, the quorum sensing signal produced by bacterial phytopathogens, is able to directly modulate plant plasma membrane dynamics by interfering with host lipid profile and thereby, suppress plant immunity responses.

  • MIC26 and MIC27 cooperate to regulate cardiolipin levels and the landscape of OXPHOS complexes
    Open Access
    MIC26 and MIC27 cooperate to regulate cardiolipin levels and the landscape of OXPHOS complexes

    Ruchika Anand, Arun Kumar Kondadi, Jana Meisterknecht, Mathias Golombek, Oliver Nortmann, Julia Riedel, Leon Peifer-Weiß, Nahal Brocke-Ahmadinejad, David Schlütermann, Björn Stork, Thomas O Eichmann, Ilka Wittig, Andreas S Reichert

    Ruchika Anand ... Andreas S Reichert

    Published 11 August 2020

    Apolipoproteins of MICOS, MIC26 and MIC27, cooperatively manage cristae structure, cardiolipin levels, and the global stability and integrity of respiratory chain supercomplexes and F1Fo–ATP synthase.

  • Thymosin α1 protects from CTLA-4 intestinal immunopathology
    Open Access
    Thymosin α1 protects from CTLA-4 intestinal immunopathology

    Giorgia Renga, Marina M Bellet, Marilena Pariano, Marco Gargaro, Claudia Stincardini, Fiorella D’Onofrio, Paolo Mosci, Stefano Brancorsini, Andrea Bartoli, Allan L Goldstein, Enrico Garaci, Luigina Romani, Claudio Costantini

    Giorgia Renga ... Claudio Costantini

    Published 14 August 2020

    This study demonstrates that Tα1 protects mice from anti–CTLA-4–induced colitis and sustains its antitumor activity, thus suggesting that Tα1 may be used in combination protocols.

  • DDX5 promotes oncogene C3 and FABP1 expressions and drives intestinal inflammation and tumorigenesis
    Open Access
    DDX5 promotes oncogene C3 and FABP1 expressions and drives intestinal inflammation and tumorigenesis

    Nazia Abbasi, Tianyun Long, Yuxin Li, Brian A Yee, Benjamin S Cho, Juan E Hernandez, Evelyn Ma, Parth R Patel, Debashis Sahoo, Ibrahim M Sayed, Nissi Varki, Soumita Das, Pradipta Ghosh, Gene W Yeo, Wendy Jia Men Huang

    Nazia Abbasi ... Wendy Jia Men Huang

    Published 18 August 2020

    In intestinal epithelial cells (IECs), DDX5 promotes the expression of immune response genes and oncogenes posttranscriptionally and is a novel therapeutic target for treating colitis and intestinal cancers.

  • The RECQL helicase prevents replication fork collapse during replication stress
    Open Access
    The RECQL helicase prevents replication fork collapse during replication stress

    Bente Benedict, Marit AE van Bueren, Frank PA van Gemert, Cor Lieftink, Sergi Guerrero Llobet, Marcel ATM van Vugt, Roderick L Beijersbergen, Hein te Riele

    Bente Benedict ... Hein te Riele

    Published 20 August 2020

    This work shows that RECQL is an essential player in the protection of stalled replication forks and possibly the restart of broken replication forks, thereby representing a target for cancer therapy.

  • A dichotomy of gene regulatory associations during the activated B-cell to plasmablast transition
    Open Access
    A dichotomy of gene regulatory associations during the activated B-cell to plasmablast transition

    Mario Cocco, Matthew A Care, Amel Saadi, Muna Al-Maskari, Gina Doody, Reuben Tooze

    Mario Cocco ... Reuben Tooze

    Published 25 August 2020

    As human B-cells differentiate, IRF4 switches occupancy and acquires CTCF colocalisation and IRF4 regulatory output diverts from cell activation to plasma cell state genes in conjunction with XBP1, whereas BLIMP1 represses activation.

Resource

  • Genome-wide R-loop analysis defines unique roles for DDX5, XRN2, and PRMT5 in DNA/RNA hybrid resolution
    Open Access
    Genome-wide R-loop analysis defines unique roles for DDX5, XRN2, and PRMT5 in DNA/RNA hybrid resolution

    Oscar D Villarreal, Sofiane Y Mersaoui, Zhenbao Yu, Jean-Yves Masson, Stéphane Richard

    Oscar D Villarreal ... Stéphane Richard

    Published 3 August 2020

    Genome-wide analysis of R-loop alterations in U2OS cells deficient of DDX5, XRN2, and PRMT5 identify >50,650 DRIP-seq peaks spanning ∼4.5% of the genomic sequence. R-loops near TSS generated intergenic antisense transcription.

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Volume 3, No. 10
October 2020
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