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Initial phospholipid-dependent Irgb6 targeting to Toxoplasma gondii vacuoles mediates host defense

Youngae Lee, Hiroshi Yamada, Ariel Pradipta, Ji Su Ma, Masaaki Okamoto, Hikaru Nagaoka, Eizo Takashima, Daron M Standley, Miwa Sasai, Kohji Takei, View ORCID ProfileMasahiro Yamamoto  Correspondence email
Youngae Lee
1Department of Immunoparasitology, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan
3Laboratory of Immunoparasitology, WPI Immunology Frontier Research Center, Osaka University, Osaka, Japan
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Hiroshi Yamada
5Department of Neuroscience, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan
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Ariel Pradipta
1Department of Immunoparasitology, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan
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Ji Su Ma
1Department of Immunoparasitology, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan
3Laboratory of Immunoparasitology, WPI Immunology Frontier Research Center, Osaka University, Osaka, Japan
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Masaaki Okamoto
1Department of Immunoparasitology, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan
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Hikaru Nagaoka
6Division of Malaria Research, Proteo-Science Center, Ehime University, Ehime, Japan
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Eizo Takashima
6Division of Malaria Research, Proteo-Science Center, Ehime University, Ehime, Japan
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Daron M Standley
2Department of Genome Informatics, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan
4Laboratory of Systems Immunology, WPI Immunology Frontier Research Center, Osaka University, Osaka, Japan
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Miwa Sasai
1Department of Immunoparasitology, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan
3Laboratory of Immunoparasitology, WPI Immunology Frontier Research Center, Osaka University, Osaka, Japan
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Kohji Takei
5Department of Neuroscience, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan
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Masahiro Yamamoto
1Department of Immunoparasitology, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan
3Laboratory of Immunoparasitology, WPI Immunology Frontier Research Center, Osaka University, Osaka, Japan
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  • ORCID record for Masahiro Yamamoto
  • For correspondence: myamamoto@biken.osaka-u.ac.jp
Published 18 December 2019. DOI: 10.26508/lsa.201900549
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Irgb6 roles in anti-T. gondii responses
Youngae Lee, Hiroshi Yamada, Ariel Pradipta, Ji Su Ma, Masaaki Okamoto, Hikaru Nagaoka, Eizo Takashima, Daron M Standley, Miwa Sasai, Kohji Takei, Masahiro Yamamoto
Life Science Alliance Dec 2019, 3 (1) e201900549; DOI: 10.26508/lsa.201900549

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Irgb6 roles in anti-T. gondii responses
Youngae Lee, Hiroshi Yamada, Ariel Pradipta, Ji Su Ma, Masaaki Okamoto, Hikaru Nagaoka, Eizo Takashima, Daron M Standley, Miwa Sasai, Kohji Takei, Masahiro Yamamoto
Life Science Alliance Dec 2019, 3 (1) e201900549; DOI: 10.26508/lsa.201900549
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Volume 3, No. 1
January 2020
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  • Inducible nitric oxide synthase (iNOS) is necessary for GBP-mediated T. gondii restriction in murine macrophages via vacuole nitration and intravacuolar network collapse
  • Structural basis of membrane recognition of Toxoplasma gondii vacuole by Irgb6
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