Expression of AXL receptor tyrosine kinase relates to monocyte dysfunction and severity of cirrhosis

Robert Brenig; Oltin T Pop; Evangelos Triantafyllou; Anne Geng; Arjuna Singanayagam; Christian Perez-Shibayama; Lenka Besse; Jovana Cupovic; Patrizia Künzler; Tuyana Boldanova; Stephan Brand; David Semela; François HT Duong; Christopher J Weston; Burkhard Ludewig; Markus H Heim; Julia Wendon; Charalambos G Antoniades; Christine Bernsmeier

doi:10.26508/lsa.201900465

Research Article

Open Access

Expression of AXL receptor tyrosine kinase relates to monocyte dysfunction and severity of cirrhosis

View ORCID ProfileRobert Brenig, Oltin T Pop, View ORCID ProfileEvangelos Triantafyllou, Anne Geng, View ORCID ProfileArjuna Singanayagam, Christian Perez-Shibayama, Lenka Besse, Jovana Cupovic, View ORCID ProfilePatrizia Künzler, Tuyana Boldanova, Stephan Brand, David Semela, François HT Duong, View ORCID ProfileChristopher J Weston, Burkhard Ludewig, View ORCID ProfileMarkus H Heim, Julia Wendon, Charalambos G Antoniades, View ORCID ProfileChristine Bernsmeier Correspondence email

Robert Brenig

Department of Biomedicine, University of Basel and University Centre for Gastrointestinal and Liver Diseases, Basel, SwitzerlandMedical Research Centre and Division of Gastroenterology and Hepatology, Cantonal Hospital St. Gallen, St. Gallen, Switzerland

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Oltin T Pop

Medical Research Centre and Division of Gastroenterology and Hepatology, Cantonal Hospital St. Gallen, St. Gallen, SwitzerlandInstitute of Liver Studies, King’s College Hospital, King’s College London, London, UK

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Evangelos Triantafyllou

Institute of Liver Studies, King’s College Hospital, King’s College London, London, UKHepatology Department, St. Mary’s Hospital, Imperial College London, London, UK

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Anne Geng

Department of Biomedicine, University of Basel and University Centre for Gastrointestinal and Liver Diseases, Basel, Switzerland

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Arjuna Singanayagam

Institute of Liver Studies, King’s College Hospital, King’s College London, London, UKHepatology Department, St. Mary’s Hospital, Imperial College London, London, UK

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Christian Perez-Shibayama

Medical Research Centre and Division of Gastroenterology and Hepatology, Cantonal Hospital St. Gallen, St. Gallen, SwitzerlandInstitute of Immunobiology, Medical Research Centre, Cantonal Hospital St. Gallen, St. Gallen, Switzerland

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Lenka Besse

Laboratory of Experimental Oncology, Department of Oncology and Haematology, Cantonal Hospital St. Gallen, St. Gallen, Switzerland

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Jovana Cupovic

Institute of Immunobiology, Medical Research Centre, Cantonal Hospital St. Gallen, St. Gallen, Switzerland

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Patrizia Künzler

Medical Research Centre and Division of Gastroenterology and Hepatology, Cantonal Hospital St. Gallen, St. Gallen, Switzerland

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Tuyana Boldanova

Department of Biomedicine, University of Basel and University Centre for Gastrointestinal and Liver Diseases, Basel, Switzerland

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Stephan Brand

Medical Research Centre and Division of Gastroenterology and Hepatology, Cantonal Hospital St. Gallen, St. Gallen, Switzerland

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David Semela

Medical Research Centre and Division of Gastroenterology and Hepatology, Cantonal Hospital St. Gallen, St. Gallen, Switzerland

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François HT Duong

Department of Biomedicine, University of Basel and University Centre for Gastrointestinal and Liver Diseases, Basel, Switzerland

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Christopher J Weston

Centre for Liver Research and National Institute for Health Research, Biomedical Research Unit, University of Birmingham, Birmingham, UK

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Burkhard Ludewig

Institute of Immunobiology, Medical Research Centre, Cantonal Hospital St. Gallen, St. Gallen, Switzerland

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Markus H Heim

Department of Biomedicine, University of Basel and University Centre for Gastrointestinal and Liver Diseases, Basel, Switzerland

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Julia Wendon

Institute of Liver Studies, King’s College Hospital, King’s College London, London, UK

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Charalambos G Antoniades

Institute of Liver Studies, King’s College Hospital, King’s College London, London, UKHepatology Department, St. Mary’s Hospital, Imperial College London, London, UK

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Christine Bernsmeier

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ORCID record for Christine Bernsmeier
For correspondence: c.bernsmeier@unibas.ch

Published 10 December 2019. DOI: 10.26508/lsa.201900465

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AXL⁺ monocytes alter immune function in cirrhosis

Robert Brenig, Oltin T Pop, Evangelos Triantafyllou, Anne Geng, Arjuna Singanayagam, Christian Perez-Shibayama, Lenka Besse, Jovana Cupovic, Patrizia Künzler, Tuyana Boldanova, Stephan Brand, David Semela, François HT Duong, Christopher J Weston, Burkhard Ludewig, Markus H Heim, Julia Wendon, Charalambos G Antoniades, Christine Bernsmeier

Life Science Alliance Dec 2019, 3 (1) e201900465; DOI: 10.26508/lsa.201900465