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Research Article
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aYAP modRNA reduces cardiac inflammation and hypertrophy in a murine ischemia-reperfusion model

View ORCID ProfileJinmiao Chen, Qing Ma, View ORCID ProfileJustin S King, Yan Sun, Bing Xu, Xiaoyu Zhang, Sylvia Zohrabian, Haipeng Guo, Wenqing Cai, View ORCID ProfileGavin Li, Ivone Bruno, John P Cooke, Chunsheng Wang, View ORCID ProfileMaria Kontaridis, Da-Zhi Wang, Hongbo Luo, William T Pu  Correspondence email, View ORCID ProfileZhiqiang Lin  Correspondence email
Jinmiao Chen
1Boston Children’s Hospital, Boston, MA, USA
2Department of Cardiovascular Surgery and Shanghai Institute of Cardiovascular Disease, Zhongshan Hospital, Fudan University, Shanghai, China
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  • ORCID record for Jinmiao Chen
Qing Ma
1Boston Children’s Hospital, Boston, MA, USA
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Justin S King
1Boston Children’s Hospital, Boston, MA, USA
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  • ORCID record for Justin S King
Yan Sun
3Masonic Medical Research Institute, Utica, NY, USA
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Bing Xu
3Masonic Medical Research Institute, Utica, NY, USA
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Xiaoyu Zhang
1Boston Children’s Hospital, Boston, MA, USA
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Sylvia Zohrabian
1Boston Children’s Hospital, Boston, MA, USA
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Haipeng Guo
1Boston Children’s Hospital, Boston, MA, USA
4Department of Critical Care Medicine, Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Qilu Hospital of Shandong University, Jinan, China
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Wenqing Cai
5Boston Children’s Hospital and Dana Farber Cancer Institute, Boston, MA, USA
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Gavin Li
1Boston Children’s Hospital, Boston, MA, USA
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  • ORCID record for Gavin Li
Ivone Bruno
6Houston Methodist Research Institute, Houston, TX, USA
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John P Cooke
6Houston Methodist Research Institute, Houston, TX, USA
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Chunsheng Wang
2Department of Cardiovascular Surgery and Shanghai Institute of Cardiovascular Disease, Zhongshan Hospital, Fudan University, Shanghai, China
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Maria Kontaridis
3Masonic Medical Research Institute, Utica, NY, USA
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Da-Zhi Wang
1Boston Children’s Hospital, Boston, MA, USA
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Hongbo Luo
1Boston Children’s Hospital, Boston, MA, USA
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William T Pu
1Boston Children’s Hospital, Boston, MA, USA
7Harvard Stem Cell Institute, Cambridge, MA, USA
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  • For correspondence: wpu@pulab.org
Zhiqiang Lin
1Boston Children’s Hospital, Boston, MA, USA
3Masonic Medical Research Institute, Utica, NY, USA
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  • ORCID record for Zhiqiang Lin
  • For correspondence: zlin@mmri.edu
Published 16 December 2019. DOI: 10.26508/lsa.201900424
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Article Information

vol. 3 no. 1 e201900424
DOI 
https://doi.org/10.26508/lsa.201900424
PubMed 
31843959

Published By 
Life Science Alliance
Online ISSN 
2575-1077
History 
  • Received May 10, 2019
  • Revision received December 4, 2019
  • Accepted December 5, 2019
  • Published online December 16, 2019.

Copyright & Usage 
© 2019 Chen et al. This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).

Author Information

  1. Jinmiao Chen1,2,*,
  2. Qing Ma1,*,
  3. Justin S King1,
  4. Yan Sun3,
  5. Bing Xu3,
  6. Xiaoyu Zhang1,
  7. Sylvia Zohrabian1,
  8. Haipeng Guo1,4,
  9. Wenqing Cai5,
  10. Gavin Li1,
  11. Ivone Bruno6,
  12. John P Cooke6,
  13. Chunsheng Wang2,
  14. Maria Kontaridis3,
  15. Da-Zhi Wang1,
  16. Hongbo Luo1,
  17. William T Pu1,7⇑ and
  18. Zhiqiang Lin1,3⇑
  1. 1Boston Children’s Hospital, Boston, MA, USA
  2. 2Department of Cardiovascular Surgery and Shanghai Institute of Cardiovascular Disease, Zhongshan Hospital, Fudan University, Shanghai, China
  3. 3Masonic Medical Research Institute, Utica, NY, USA
  4. 4Department of Critical Care Medicine, Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Health, Qilu Hospital of Shandong University, Jinan, China
  5. 5Boston Children’s Hospital and Dana Farber Cancer Institute, Boston, MA, USA
  6. 6Houston Methodist Research Institute, Houston, TX, USA
  7. 7Harvard Stem Cell Institute, Cambridge, MA, USA
  1. Correspondence: zlin{at}mmri.edu
  2. wpu{at}pulab.org
  1. ↵* Jinmiao Chen and Qing Ma contributed equally to this work

View Full Text

Funding

  • China Scholarship Council

    J Chen
  • American Heart Association Scientist Development

    15SDG25590001
    Z Lin
  • Progenitor Cell Biology Consortium “JUMP START” AWARDS

    5U01HL099997-07
    Z Lin
  • National Institutes of Health

    HL138454-01
    Z Lin
  • National Institutes of Health

    R01 HL116461
    WT Pu
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aYAP modRNA reduces cardiac reperfusion injury
Jinmiao Chen, Qing Ma, Justin S King, Yan Sun, Bing Xu, Xiaoyu Zhang, Sylvia Zohrabian, Haipeng Guo, Wenqing Cai, Gavin Li, Ivone Bruno, John P Cooke, Chunsheng Wang, Maria Kontaridis, Da-Zhi Wang, Hongbo Luo, William T Pu, Zhiqiang Lin
Life Science Alliance Dec 2019, 3 (1) e201900424; DOI: 10.26508/lsa.201900424

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aYAP modRNA reduces cardiac reperfusion injury
Jinmiao Chen, Qing Ma, Justin S King, Yan Sun, Bing Xu, Xiaoyu Zhang, Sylvia Zohrabian, Haipeng Guo, Wenqing Cai, Gavin Li, Ivone Bruno, John P Cooke, Chunsheng Wang, Maria Kontaridis, Da-Zhi Wang, Hongbo Luo, William T Pu, Zhiqiang Lin
Life Science Alliance Dec 2019, 3 (1) e201900424; DOI: 10.26508/lsa.201900424
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Volume 3, No. 1
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