Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Newest Articles
    • Current Issue
    • Methods & Resources
    • Author Interviews
    • Archive
    • Subjects
  • Collections
  • Submit
    • Submit a Manuscript
    • Author Guidelines
    • License, Copyright, Fee
    • FAQ
    • Why submit
  • About
    • About Us
    • Editors & Staff
    • Board Members
    • Licensing and Reuse
    • Reviewer Guidelines
    • Privacy Policy
    • Advertise
    • Contact Us
    • LSA LLC
  • Alerts
  • Other Publications
    • EMBO Press
    • The EMBO Journal
    • EMBO reports
    • EMBO Molecular Medicine
    • Molecular Systems Biology
    • Rockefeller University Press
    • Journal of Cell Biology
    • Journal of Experimental Medicine
    • Journal of General Physiology
    • Journal of Human Immunity
    • Cold Spring Harbor Laboratory Press
    • Genes & Development
    • Genome Research

User menu

  • My alerts

Search

  • Advanced search
Life Science Alliance
  • Other Publications
    • EMBO Press
    • The EMBO Journal
    • EMBO reports
    • EMBO Molecular Medicine
    • Molecular Systems Biology
    • Rockefeller University Press
    • Journal of Cell Biology
    • Journal of Experimental Medicine
    • Journal of General Physiology
    • Journal of Human Immunity
    • Cold Spring Harbor Laboratory Press
    • Genes & Development
    • Genome Research
  • My alerts
Life Science Alliance

Advanced Search

  • Home
  • Articles
    • Newest Articles
    • Current Issue
    • Methods & Resources
    • Author Interviews
    • Archive
    • Subjects
  • Collections
  • Submit
    • Submit a Manuscript
    • Author Guidelines
    • License, Copyright, Fee
    • FAQ
    • Why submit
  • About
    • About Us
    • Editors & Staff
    • Board Members
    • Licensing and Reuse
    • Reviewer Guidelines
    • Privacy Policy
    • Advertise
    • Contact Us
    • LSA LLC
  • Alerts
  • Follow LSA on Bluesky
  • Follow lsa Template on Twitter

Table of Contents

January 2020 | Volume 3, No. 1

Research Articles

  • TspanC8 tetraspanins differentially regulate ADAM10 endocytosis and half-life
    Open Access
    TspanC8 tetraspanins differentially regulate ADAM10 endocytosis and half-life

    Etienne Eschenbrenner, Stéphanie Jouannet, Denis Clay, Joëlle Chaker, Claude Boucheix, Christel Brou, Michael G Tomlinson, Stéphanie Charrin, Eric Rubinstein

    Etienne Eschenbrenner ... Eric Rubinstein

    Published 2 December 2019

    This study demonstrates that the tetraspanins Tspan5 and Tspan15 which directly associate with the metalloprotease ADAM10 have an opposite impact on its endocytosis and half-life.

  • Essential functions of Runx/Cbfβ in gut conventional dendritic cells for priming Rorγt<sup>+</sup> T cells
    Open Access
    Essential functions of Runx/Cbfβ in gut conventional dendritic cells for priming Rorγt+ T cells

    Mari Tenno, Alicia Yoke Wei Wong, Mika Ikegaya, Eiji Miyauchi, Wooseok Seo, Peter See, Tamotsu Kato, Takashi Taida, Michiko Ohno-Oishi, Hiroshi Ohno, Hideyuki Yoshida, Florent Ginhoux, Ichiro Taniuchi

    Mari Tenno ... Ichiro Taniuchi

    Published 9 December 2019

    Loss of Runx/Cbfβ complexes during DC development leads to a loss of gut CD103+CD11b+ cDC2s, which was accompanied with impaired differentiation of both Rorγt+ Th17 cells and type 3 Rorγt+ Treg cells.

  • MERLIN: a novel BRET-based proximity biosensor for studying mitochondria–ER contact sites
    Open Access
    MERLIN: a novel BRET-based proximity biosensor for studying mitochondria–ER contact sites

    Vanessa Hertlein, Hector Flores-Romero, Kushal K Das, Sebastian Fischer, Michael Heunemann, Maria Calleja-Felipe, Shira Knafo, Katharina Hipp, Klaus Harter, Julia C Fitzgerald, Ana J García-Sáez

    Vanessa Hertlein ... Ana J García-Sáez

    Published 9 December 2019

    MERLIN is a novel biosensor that generates a BRET signal with a signal-to-noise ratio that is sufficient to enable sensing the proximity between the mitochondria and the ER without forcing interaction or establishing artificial connections at the MERCs.

  • Expression of AXL receptor tyrosine kinase relates to monocyte dysfunction and severity of cirrhosis
    Open Access
    Expression of AXL receptor tyrosine kinase relates to monocyte dysfunction and severity of cirrhosis

    Robert Brenig, Oltin T Pop, Evangelos Triantafyllou, Anne Geng, Arjuna Singanayagam, Christian Perez-Shibayama, Lenka Besse, Jovana Cupovic, Patrizia Künzler, Tuyana Boldanova, Stephan Brand, David Semela, François HT Duong, Christopher J Weston, Burkhard Ludewig, Markus H Heim, Julia Wendon, Charalambos G Antoniades, Christine Bernsmeier

    Robert Brenig ... Christine Bernsmeier

    Published 10 December 2019

    Immune dysfunction determines morbidity and mortality in liver cirrhosis. Distinct AXL-expressing circulating monocytes, which regulate antimicrobial responses, expand with progression of the disease.

  • Bat IFITM3 restriction depends on S-palmitoylation and a polymorphic site within the CD225 domain
    Open Access
    Bat IFITM3 restriction depends on S-palmitoylation and a polymorphic site within the CD225 domain

    Camilla TO Benfield, Farrell MacKenzie, Markus Ritzefeld, Michela Mazzon, Stuart Weston, Edward W Tate, Boon Han Teo, Sarah E Smith, Paul Kellam, Edward C Holmes, Mark Marsh

    Camilla TO Benfield ... Mark Marsh

    Published 11 December 2019

    Comparative analysis reveals adaptive evolution of bat IFITMs and a naturally polymorphic site within the conserved CD225 domain that affects S-palmitoylation and antiviral function of bat IFITM3.

  • Metabolome-based prediction of yield heterosis contributes to the breeding of elite rice
    Open Access
    Metabolome-based prediction of yield heterosis contributes to the breeding of elite rice

    Zhiwu Dan, Yunping Chen, Weibo Zhao, Qiong Wang, Wenchao Huang

    Zhiwu Dan ... Wenchao Huang

    Published 13 December 2019

    Metabolite profiles obtained from parental seedlings can predict yield heterosis of rice hybrids with correctly dissected population structure across different growth conditions.

  • aYAP modRNA reduces cardiac inflammation and hypertrophy in a murine ischemia-reperfusion model
    Open Access
    aYAP modRNA reduces cardiac inflammation and hypertrophy in a murine ischemia-reperfusion model

    Jinmiao Chen, Qing Ma, Justin S King, Yan Sun, Bing Xu, Xiaoyu Zhang, Sylvia Zohrabian, Haipeng Guo, Wenqing Cai, Gavin Li, Ivone Bruno, John P Cooke, Chunsheng Wang, Maria Kontaridis, Da-Zhi Wang, Hongbo Luo, William T Pu, Zhiqiang Lin

    Jinmiao Chen ... Zhiqiang Lin

    Published 16 December 2019

    Transient activation of YAP with a modified mRNA after ischemia-reperfusion stress reduces cardiac inflammation, attenuates cardiac hypertrophic remodeling and helps to salvage the myocardium.

  • Initial phospholipid-dependent Irgb6 targeting to <em>Toxoplasma gondii</em> vacuoles mediates host defense
    Open Access
    Initial phospholipid-dependent Irgb6 targeting to Toxoplasma gondii vacuoles mediates host defense

    Youngae Lee, Hiroshi Yamada, Ariel Pradipta, Ji Su Ma, Masaaki Okamoto, Hikaru Nagaoka, Eizo Takashima, Daron M Standley, Miwa Sasai, Kohji Takei, Masahiro Yamamoto

    Youngae Lee ... Masahiro Yamamoto

    Published 18 December 2019

    Irgb6 has a role in the cell-autonomous response against T. gondii and involves ubiquitination and breakdown of vacuoles via binding of a specific phospholipid on the parasitophorous vacuole membrane.

  • Dual role of a GTPase conformational switch for membrane fusion by mitofusin ubiquitylation
    Open Access
    Dual role of a GTPase conformational switch for membrane fusion by mitofusin ubiquitylation

    Ramona Schuster, Vincent Anton, Tânia Simões, Selver Altin, Fabian den Brave, Thomas Hermanns, Manuela Hospenthal, David Komander, Gunnar Dittmar, R Jürgen Dohmen, Mafalda Escobar-Henriques

    Ramona Schuster ... Mafalda Escobar-Henriques

    Published 19 December 2019

    Mitochondrial fusion requires a conformational change in α4 of the GTPase domain, followed by AAA-ATPase regulation, thus revealing striking mechanistic similarities between small and large GTPases.

  • A key region of molecular specificity orchestrates unique ephrin-B1 utilization by Cedar virus
    Open Access
    A key region of molecular specificity orchestrates unique ephrin-B1 utilization by Cedar virus

    Rhys Pryce, Kristopher Azarm, Ilona Rissanen, Karl Harlos, Thomas A Bowden, Benhur Lee

    Rhys Pryce ... Benhur Lee

    Published 20 December 2019

    An expanded hydrophobic cavity within the structurally constrained receptor-binding site of the Cedar virus attachment glycoprotein facilitates idiosyncratic utilization of ephrin-B1.

  • Loss of autophagy impairs physiological steatosis by accumulation of NCoR1
    Open Access
    Loss of autophagy impairs physiological steatosis by accumulation of NCoR1

    Shun-saku Takahashi, Yu-Shin Sou, Tetsuya Saito, Akiko Kuma, Takayuki Yabe, Yuki Sugiura, Hyeon-Cheol Lee, Makoto Suematsu, Takehiko Yokomizo, Masato Koike, Shuji Terai, Noboru Mizushima, Satoshi Waguri, Masaaki Komatsu

    Shun-saku Takahashi ... Masaaki Komatsu

    Published 26 December 2019

    Autophagy regulates fatty acid and triglyceride synthesis at the transcriptional level by fine-tuning the levels of NCoR1, a negative regulator of nuclear receptors. Defective autophagy impairs physiological steatosis both under fasting conditions and after hepatectomy.

  • Oscillatory cAMP signaling rapidly alters H3K4 methylation
    Open Access
    Oscillatory cAMP signaling rapidly alters H3K4 methylation

    Tyler C Huff, Vladimir Camarena, David W Sant, Zachary Wilkes, Derek Van Booven, Allegra T Aron, Ryan K Muir, Adam R Renslo, Christopher J Chang, Paula V Monje, Gaofeng Wang

    Tyler C Huff ... Gaofeng Wang

    Published 27 December 2019

    This work explores how GPCR-cAMP signaling dynamically influences histone methylation by altering intracellular labile Fe(II) levels and subsequently modulating histone demethylase activity.

  • Nup93 regulates breast tumor growth by modulating cell proliferation and actin cytoskeleton remodeling
    Open Access
    Nup93 regulates breast tumor growth by modulating cell proliferation and actin cytoskeleton remodeling

    Simone Bersini, Nikki K Lytle, Roberta Schulte, Ling Huang, Geoffrey M Wahl, Martin W Hetzer

    Simone Bersini ... Martin W Hetzer

    Published 20 January 2020

    This study highlights the role of Nup93-chromatin interactions in driving triple-negative breast cancer propagation through modulation of the actin cytoskeleton, cell migration and proliferation.

Methods

  • In vivo and in vitro knockout system labelled using fluorescent protein via microhomology-mediated end joining
    Open Access
    In vivo and in vitro knockout system labelled using fluorescent protein via microhomology-mediated end joining

    Shota Katayama, Kota Sato, Toru Nakazawa

    Shota Katayama ... Toru Nakazawa

    Published 24 December 2019

    This study provides a new method that enables the labelling of knockout cells with fluorescent protein through microhomology-mediated end joining (MMEJ)–based knock-in.

Resources

  • A comprehensive resource for retrieving, visualizing, and integrating functional genomics data
    Open Access
    A comprehensive resource for retrieving, visualizing, and integrating functional genomics data

    Matthias Blum, Pierre-Etienne Cholley, Valeriya Malysheva, Samuel Nicaise, Julien Moehlin, Hinrich Gronemeyer, Marco Antonio Mendoza-Parra

    Matthias Blum ... Marco Antonio Mendoza-Parra

    Published 9 December 2019

    This study presents qcGenomics, a user-friendly online resource for ultrafast retrieval, visualization, and comparative analysis of tens of thousands of genomics datasets to gain new functional insight from global or focused multi-dimensional data integration.

Back to top
PreviousNext
Issue Cover

In this Issue

Volume 3, No. 1
January 2020
  • Table of Contents
  • Cover (PDF)
  • About the Cover
  • Masthead (PDF)
Sign up for alerts

Jump to

  • Research Articles
  • Methods
  • Resources
Advertisement

EMBO Press LogoRockefeller University Press LogoCold Spring Harbor Logo

Content

  • Home
  • Newest Articles
  • Current Issue
  • Archive
  • Subject Collections

For Authors

  • Submit a Manuscript
  • Author Guidelines
  • License, copyright, Fee

Other Services

  • Alerts
  • Bluesky
  • X/Twitter
  • RSS Feeds

More Information

  • Editors & Staff
  • Reviewer Guidelines
  • Feedback
  • Licensing and Reuse
  • Privacy Policy

ISSN: 2575-1077
© 2025 Life Science Alliance LLC

Life Science Alliance is registered as a trademark in the U.S. Patent and Trade Mark Office and in the European Union Intellectual Property Office.