Cx3cr1-deficient microglia exhibit a premature aging transcriptome

Stefka Gyoneva; Raghavendra Hosur; David Gosselin; Baohong Zhang; Zhengyu Ouyang; Anne C Cotleur; Michael Peterson; Norm Allaire; Ravi Challa; Patrick Cullen; Chris Roberts; Kelly Miao; Taylor L Reynolds; Christopher K Glass; Linda Burkly; Richard M Ransohoff

doi:10.26508/lsa.201900453

Research Article

Open Access

Cx3cr1-deficient microglia exhibit a premature aging transcriptome

View ORCID ProfileStefka Gyoneva Correspondence email, Raghavendra Hosur, David Gosselin, Baohong Zhang, Zhengyu Ouyang, View ORCID ProfileAnne C Cotleur, View ORCID ProfileMichael Peterson, Norm Allaire, Ravi Challa, Patrick Cullen, Chris Roberts, Kelly Miao, Taylor L Reynolds, View ORCID ProfileChristopher K Glass, Linda Burkly, View ORCID ProfileRichard M Ransohoff Correspondence email

Stefka Gyoneva

1Acute Neurology, Biogen, Cambridge, MA, USA

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For correspondence: Stefka.gyoneva@biogen.com

Raghavendra Hosur

2Computational Biology and Genomics, Biogen, Cambridge, MA, USA

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David Gosselin

3Cell and Molecular Medicine, University of California San Diego, San Diego, CA, USA

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Baohong Zhang

2Computational Biology and Genomics, Biogen, Cambridge, MA, USA

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Zhengyu Ouyang

3Cell and Molecular Medicine, University of California San Diego, San Diego, CA, USA

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Anne C Cotleur

1Acute Neurology, Biogen, Cambridge, MA, USA

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ORCID record for Anne C Cotleur

Michael Peterson

4Translational Neuropathology, Biogen, Cambridge, MA, USA

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ORCID record for Michael Peterson

Norm Allaire

2Computational Biology and Genomics, Biogen, Cambridge, MA, USA

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Ravi Challa

2Computational Biology and Genomics, Biogen, Cambridge, MA, USA

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Patrick Cullen

2Computational Biology and Genomics, Biogen, Cambridge, MA, USA

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Chris Roberts

2Computational Biology and Genomics, Biogen, Cambridge, MA, USA

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Kelly Miao

1Acute Neurology, Biogen, Cambridge, MA, USA

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Taylor L Reynolds

4Translational Neuropathology, Biogen, Cambridge, MA, USA

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Christopher K Glass

3Cell and Molecular Medicine, University of California San Diego, San Diego, CA, USA

5School of Medicine, University of California San Diego, San Diego, CA, USA

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Linda Burkly

1Acute Neurology, Biogen, Cambridge, MA, USA

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Richard M Ransohoff

1Acute Neurology, Biogen, Cambridge, MA, USA

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ORCID record for Richard M Ransohoff
For correspondence: Richard_Ransohoff@hms.harvard.edu

Published 2 December 2019. DOI: 10.26508/lsa.201900453

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Premature aging in Cx3cr1-KO microglia

Stefka Gyoneva, Raghavendra Hosur, David Gosselin, Baohong Zhang, Zhengyu Ouyang, Anne C Cotleur, Michael Peterson, Norm Allaire, Ravi Challa, Patrick Cullen, Chris Roberts, Kelly Miao, Taylor L Reynolds, Christopher K Glass, Linda Burkly, Richard M Ransohoff

Life Science Alliance Dec 2019, 2 (6) e201900453; DOI: 10.26508/lsa.201900453