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Research Article
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Cx3cr1-deficient microglia exhibit a premature aging transcriptome

View ORCID ProfileStefka Gyoneva  Correspondence email, Raghavendra Hosur, David Gosselin, Baohong Zhang, Zhengyu Ouyang, View ORCID ProfileAnne C Cotleur, View ORCID ProfileMichael Peterson, Norm Allaire, Ravi Challa, Patrick Cullen, Chris Roberts, Kelly Miao, Taylor L Reynolds, View ORCID ProfileChristopher K Glass, Linda Burkly, View ORCID ProfileRichard M Ransohoff  Correspondence email
Stefka Gyoneva
1Acute Neurology, Biogen, Cambridge, MA, USA
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  • ORCID record for Stefka Gyoneva
  • For correspondence: Stefka.gyoneva@biogen.com
Raghavendra Hosur
2Computational Biology and Genomics, Biogen, Cambridge, MA, USA
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David Gosselin
3Cell and Molecular Medicine, University of California San Diego, San Diego, CA, USA
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Baohong Zhang
2Computational Biology and Genomics, Biogen, Cambridge, MA, USA
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Zhengyu Ouyang
3Cell and Molecular Medicine, University of California San Diego, San Diego, CA, USA
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Anne C Cotleur
1Acute Neurology, Biogen, Cambridge, MA, USA
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  • ORCID record for Anne C Cotleur
Michael Peterson
4Translational Neuropathology, Biogen, Cambridge, MA, USA
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  • ORCID record for Michael Peterson
Norm Allaire
2Computational Biology and Genomics, Biogen, Cambridge, MA, USA
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Ravi Challa
2Computational Biology and Genomics, Biogen, Cambridge, MA, USA
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Patrick Cullen
2Computational Biology and Genomics, Biogen, Cambridge, MA, USA
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Chris Roberts
2Computational Biology and Genomics, Biogen, Cambridge, MA, USA
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Kelly Miao
1Acute Neurology, Biogen, Cambridge, MA, USA
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Taylor L Reynolds
4Translational Neuropathology, Biogen, Cambridge, MA, USA
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Christopher K Glass
3Cell and Molecular Medicine, University of California San Diego, San Diego, CA, USA
5School of Medicine, University of California San Diego, San Diego, CA, USA
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Linda Burkly
1Acute Neurology, Biogen, Cambridge, MA, USA
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Richard M Ransohoff
1Acute Neurology, Biogen, Cambridge, MA, USA
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  • ORCID record for Richard M Ransohoff
  • For correspondence: Richard_Ransohoff@hms.harvard.edu
Published 2 December 2019. DOI: 10.26508/lsa.201900453
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Article Information

vol. 2 no. 6 e201900453
DOI 
https://doi.org/10.26508/lsa.201900453
PubMed 
31792059

Published By 
Life Science Alliance
Online ISSN 
2575-1077
History 
  • Received June 6, 2019
  • Revision received November 14, 2019
  • Accepted November 17, 2019
  • Published online December 2, 2019.

Copyright & Usage 
© 2019 Gyoneva et al. This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).

Author Information

  1. Stefka Gyoneva1⇑,
  2. Raghavendra Hosur2,
  3. David Gosselin3,
  4. Baohong Zhang2,
  5. Zhengyu Ouyang3,
  6. Anne C Cotleur1,
  7. Michael Peterson4,
  8. Norm Allaire2,
  9. Ravi Challa2,
  10. Patrick Cullen2,
  11. Chris Roberts2,
  12. Kelly Miao1,
  13. Taylor L Reynolds4,
  14. Christopher K Glass3,5,
  15. Linda Burkly1 and
  16. Richard M Ransohoff1⇑
  1. 1Acute Neurology, Biogen, Cambridge, MA, USA
  2. 2Computational Biology and Genomics, Biogen, Cambridge, MA, USA
  3. 3Cell and Molecular Medicine, University of California San Diego, San Diego, CA, USA
  4. 4Translational Neuropathology, Biogen, Cambridge, MA, USA
  5. 5School of Medicine, University of California San Diego, San Diego, CA, USA
  1. Correspondence: Stefka.gyoneva{at}biogen.com
  2. Richard_Ransohoff{at}hms.harvard.edu
  • David Gosselin’s present address is CHU de Québec Research Center, Department of Molecular Medicine, Faculty of Medicine, Université Laval, Québec City, Canada

  • Richard M Ransohoff’s present address is Department of Cell Biology, Harvard Medical School, Cambridge, MA, USA

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Premature aging in Cx3cr1-KO microglia
Stefka Gyoneva, Raghavendra Hosur, David Gosselin, Baohong Zhang, Zhengyu Ouyang, Anne C Cotleur, Michael Peterson, Norm Allaire, Ravi Challa, Patrick Cullen, Chris Roberts, Kelly Miao, Taylor L Reynolds, Christopher K Glass, Linda Burkly, Richard M Ransohoff
Life Science Alliance Dec 2019, 2 (6) e201900453; DOI: 10.26508/lsa.201900453

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Premature aging in Cx3cr1-KO microglia
Stefka Gyoneva, Raghavendra Hosur, David Gosselin, Baohong Zhang, Zhengyu Ouyang, Anne C Cotleur, Michael Peterson, Norm Allaire, Ravi Challa, Patrick Cullen, Chris Roberts, Kelly Miao, Taylor L Reynolds, Christopher K Glass, Linda Burkly, Richard M Ransohoff
Life Science Alliance Dec 2019, 2 (6) e201900453; DOI: 10.26508/lsa.201900453
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Volume 2, No. 6
December 2019
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