Table of Contents
Research Articles
![Distinct signals and immune cells drive liver pathology and glomerulonephritis in ABIN1[D485N] mice](https://www.life-science-alliance.org/sites/default/files/styles/lsa_thumbnail_image/public/externals/1826ba9c9b29cdb17704ada32e87ee01.jpg?itok=T6YZznCZ)
Distinct signals and immune cells drive liver pathology and glomerulonephritis in ABIN1[D485N] miceThis article shows that liver and kidney damage in a lupus-prone mouse line occurs by different mechanisms and that only drugs targeting core components of signaling pathway, such as IRAK4, are able to suppress all facets of the disease.
TRAIL-induced variation of cell signaling states provides nonheritable resistance to apoptosisThis work summarizes cellular apoptotic and signaling response to TRAIL across 10 cell lines and for the first time links signaling diversity to nongenetic resistance. This high-dimensional, single-cell approach toward TRAIL resistance sets a standard in studying nongenetic resistance.
Thymosin β4 promotes autophagy and repair via HIF-1α stabilization in chronic granulomatous diseaseThis study demonstrates that thymosin β4 stabilizes HIF-1a to promote autophagy and up-regulate genes involved in tissue and mucosal barrier protection in chronic granulomatous disease.
In vitro education of human natural killer cells by KIR3DL1Using NK cells isolated from individuals who lack the Bw4 epitope on HLA-B, Pugh et al reveal that KIR3DL1+ NK cells can be educated in vitro by co-culturing them with target cells that display the missing epitope.
MMP9 modulates the metastatic cascade and immune landscape for breast cancer anti-metastatic therapyInhibition of active MMP9 early during tumorigenesis suppresses tumor cell migration, invasion, and colony formation and tilts the balance towards anti-tumor immunity by activating CD8+ T cells.
Pseudomonas aeruginosa lectin LecB impairs keratinocyte fitness by abrogating growth factor signallingThis study provides a novel function of the bacterial lectin LecB, which dampens cell proliferation and survival by targeting the insulin-like growth factor-1 for degradation, without receptor activation.
TMEM16A chloride channel does not drive mucus productionDespite being essential for airway hydration, TMEM16A is not required for mucus (MUC5AC) production. Cell proliferation is the main driver for TMEM16A up-regulation during inflammation.
The role of MHC class I recycling and Arf6 in cross-presentation by murine dendritic cellsMHC-I internalization and recycling in DCs neither requires Arf6 nor provides MHC-I to the Rab11+ endocytic recycling compartment; however, cross-presentation of immune complexes depends on Arf6.
Plasticity in salt bridge allows fusion-competent ubiquitylation of mitofusins and Cdc48 recognitionMitochondrial fusion requires an alternating salt bridge between CMT2A-associated disease residues that enable GTP hydrolysis; Fzo1 ubiquitylation then licenses post-fusion recycling by Cdc48.
Refining the adipose progenitor cell landscape in healthy and obese visceral adipose tissue using single-cell gene expression profilingThis work dissects adipose progenitor cell (APC) heterogeneity in normal and obese adipose tissue using single-cell expression profiling. Novel APC subpopulations are identified and characterized.
The AKT isoforms 1 and 2 drive B cell fate decisions during the germinal center responseB cell–intrinsic AKT1/2 are essential for germinal center formation, antibody production and affinity maturation, and plasma cell differentiation.
Cx3cr1-deficient microglia exhibit a premature aging transcriptomeGyoneva et al use RNA-seq to show that Cx3cr1-deficient microglia in young mice display a gene expression profile similar to microglia in aged mice, suggesting premature microglial aging.
Phenotypic proteomic profiling identifies a landscape of targets for circadian clock–modulating compoundsThis study provides comprehensive insights into the mechanism of action and cellular effects of circadian period–modulating compounds, which is critical for clearly defining molecular targets to modulate daily rhythms for therapeutic benefit.
ADAP1 promotes invasive squamous cell carcinoma progression and predicts patient survivalADAP1, a GTPase-activating protein (GAP) for the small GTPase ARF6, is a strong predictor of poor survival in early-stage squamous cell carcinoma patients and a critical mediator of TGF-β-induced invasive cell migration by facilitating basement membrane breakdown.
CHUK/IKK-α loss in lung epithelial cells enhances NSCLC growth associated with HIF up-regulationIKKα is an NSCLC suppressor and its loss in mouse AT-II lung epithelial cells or in human NSCLC lines increased urethane-induced adenoma growth and xenograft burdens, respectively. IKKα loss can up-regulate HIF-1α, enhancing tumor growth under hypoxia.
Methods
Reference-free transcriptome exploration reveals novel RNAs for prostate cancer diagnosisA reference-free computational workflow for the discovery of unannotated RNA biomarkers retrieves novel noncoding RNAs with high potential for prostate cancer diagnosis.
Evaluation of colorectal cancer subtypes and cell lines using deep learningA deep learning approach refines the state-of-the-art subtypes of colorectal cancer and evaluates the fidelity of cell lines that model cancer.
Resource
ADAPTABLE: a comprehensive web platform of antimicrobial peptides tailored to the user’s researchADAPTABLE is a webserver and database of antimicrobial peptides that uses sequence and property alignment to highlight their mode of action against the threat of resistance in medicine and agriculture.
