Enhanced carbonyl stress induces irreversible multimerization of CRMP2 in schizophrenia pathogenesis

Manabu Toyoshima; Xuguang Jiang; Tadayuki Ogawa; Tetsuo Ohnishi; Shogo Yoshihara; Shabeesh Balan; Takeo Yoshikawa; Nobutaka Hirokawa

doi:10.26508/lsa.201900478

Research Article

Open Access

Enhanced carbonyl stress induces irreversible multimerization of CRMP2 in schizophrenia pathogenesis

View ORCID ProfileManabu Toyoshima, View ORCID ProfileXuguang Jiang, View ORCID ProfileTadayuki Ogawa, View ORCID ProfileTetsuo Ohnishi, View ORCID ProfileShogo Yoshihara, View ORCID ProfileShabeesh Balan, View ORCID ProfileTakeo Yoshikawa Correspondence email, View ORCID ProfileNobutaka Hirokawa Correspondence email

Manabu Toyoshima

1Laboratory for Molecular Psychiatry, RIKEN Center for Brain Science, Wako, Japan

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Xuguang Jiang

2Department of Cell Biology and Anatomy, Graduate School of Medicine, University of Tokyo, Tokyo, Japan

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Tadayuki Ogawa

2Department of Cell Biology and Anatomy, Graduate School of Medicine, University of Tokyo, Tokyo, Japan

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Tetsuo Ohnishi

1Laboratory for Molecular Psychiatry, RIKEN Center for Brain Science, Wako, Japan

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Shogo Yoshihara

2Department of Cell Biology and Anatomy, Graduate School of Medicine, University of Tokyo, Tokyo, Japan

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Shabeesh Balan

1Laboratory for Molecular Psychiatry, RIKEN Center for Brain Science, Wako, Japan

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Takeo Yoshikawa

1Laboratory for Molecular Psychiatry, RIKEN Center for Brain Science, Wako, Japan

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For correspondence: takeo.yoshikawa@riken.jp

Nobutaka Hirokawa

2Department of Cell Biology and Anatomy, Graduate School of Medicine, University of Tokyo, Tokyo, Japan

3Center of Excellence in Genome Medicine Research, King Abdulaziz University, Jeddah, Saudi Arabia

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ORCID record for Nobutaka Hirokawa
For correspondence: hirokawa@m.u-tokyo.ac.jp

Published 7 October 2019. DOI: 10.26508/lsa.201900478

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CRMP2 multimerization in schizophrenia