Stromal fibroblasts induce metastatic tumor cell clusters via epithelial–mesenchymal plasticity

Yuko Matsumura; Yasuhiko Ito; Yoshihiro Mezawa; Kaidiliayi Sulidan; Yataro Daigo; Toru Hiraga; Kaoru Mogushi; Nadila Wali; Hiromu Suzuki; Takumi Itoh; Yohei Miyagi; Tomoyuki Yokose; Satoru Shimizu; Atsushi Takano; Yasuhisa Terao; Harumi Saeki; Masayuki Ozawa; Masaaki Abe; Satoru Takeda; Ko Okumura; Sonoko Habu; Okio Hino; Kazuyoshi Takeda; Michiaki Hamada; Akira Orimo

doi:10.26508/lsa.201900425

Research Article

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Stromal fibroblasts induce metastatic tumor cell clusters via epithelial–mesenchymal plasticity

Yuko Matsumura, Yasuhiko Ito, Yoshihiro Mezawa, Kaidiliayi Sulidan, Yataro Daigo, View ORCID ProfileToru Hiraga, Kaoru Mogushi, Nadila Wali, Hiromu Suzuki, View ORCID ProfileTakumi Itoh, Yohei Miyagi, View ORCID ProfileTomoyuki Yokose, Satoru Shimizu, Atsushi Takano, Yasuhisa Terao, Harumi Saeki, Masayuki Ozawa, Masaaki Abe, Satoru Takeda, Ko Okumura, Sonoko Habu, Okio Hino, View ORCID ProfileKazuyoshi Takeda, View ORCID ProfileMichiaki Hamada, View ORCID ProfileAkira Orimo Correspondence email

Yuko Matsumura

1Department of Molecular Pathogenesis, Graduate School of Medicine, Juntendo University, Tokyo, Japan

2Department of Obstetrics and Gynecology, Graduate School of Medicine, Juntendo University, Tokyo, Japan

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Yasuhiko Ito

1Department of Molecular Pathogenesis, Graduate School of Medicine, Juntendo University, Tokyo, Japan

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Yoshihiro Mezawa

1Department of Molecular Pathogenesis, Graduate School of Medicine, Juntendo University, Tokyo, Japan

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Kaidiliayi Sulidan

1Department of Molecular Pathogenesis, Graduate School of Medicine, Juntendo University, Tokyo, Japan

2Department of Obstetrics and Gynecology, Graduate School of Medicine, Juntendo University, Tokyo, Japan

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Yataro Daigo

12Center for Antibody and Vaccine Therapy, Research Hospital, Institute of Medical Science, The University of Tokyo, Tokyo, Japan

13Department of Medical Oncology and Cancer Center, Shiga University of Medical Science, Otsu, Japan

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Toru Hiraga

7Department of Histology and Cell Biology, Matsumoto Dental University, Nagano, Japan

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Kaoru Mogushi

8Intractable Disease Research Center, Graduate School of Medicine, Juntendo University, Tokyo, Japan

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Nadila Wali

1Department of Molecular Pathogenesis, Graduate School of Medicine, Juntendo University, Tokyo, Japan

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Hiromu Suzuki

15Department of Molecular Biology, School of Medicine, Sapporo Medical University, Hokkaido, Japan

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Takumi Itoh

1Department of Molecular Pathogenesis, Graduate School of Medicine, Juntendo University, Tokyo, Japan

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Yohei Miyagi

9Molecular Pathology and Genetics Division, Kanagawa Cancer Center Research Institute, Yokohama, Japan

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Tomoyuki Yokose

10Department of Pathology, Kanagawa Cancer Center, Yokohama, Japan

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Satoru Shimizu

11Department of Breast and Endocrine Surgery, Kanagawa Cancer Center, Yokohama, Japan

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Atsushi Takano

12Center for Antibody and Vaccine Therapy, Research Hospital, Institute of Medical Science, The University of Tokyo, Tokyo, Japan

13Department of Medical Oncology and Cancer Center, Shiga University of Medical Science, Otsu, Japan

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Yasuhisa Terao

2Department of Obstetrics and Gynecology, Graduate School of Medicine, Juntendo University, Tokyo, Japan

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Harumi Saeki

1Department of Molecular Pathogenesis, Graduate School of Medicine, Juntendo University, Tokyo, Japan

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Masayuki Ozawa

14Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan

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Masaaki Abe

1Department of Molecular Pathogenesis, Graduate School of Medicine, Juntendo University, Tokyo, Japan

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Satoru Takeda

2Department of Obstetrics and Gynecology, Graduate School of Medicine, Juntendo University, Tokyo, Japan

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Ko Okumura

4Atopy Research Center, Biomedical Research Center, Graduate School of Medicine, Juntendo University, Tokyo, Japan

6Department of Biofunctional Microbiota, Graduate School of Medicine, Juntendo University, Tokyo, Japan

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Sonoko Habu

4Atopy Research Center, Biomedical Research Center, Graduate School of Medicine, Juntendo University, Tokyo, Japan

6Department of Biofunctional Microbiota, Graduate School of Medicine, Juntendo University, Tokyo, Japan

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Okio Hino

1Department of Molecular Pathogenesis, Graduate School of Medicine, Juntendo University, Tokyo, Japan

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Kazuyoshi Takeda

5Division of Cell Biology, Biomedical Research Center, Graduate School of Medicine, Juntendo University, Tokyo, Japan

6Department of Biofunctional Microbiota, Graduate School of Medicine, Juntendo University, Tokyo, Japan

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Michiaki Hamada

3Department of Electrical Engineering and Bioscience, Faculty of Science and Engineering, Waseda University, Tokyo, Japan

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Akira Orimo

1Department of Molecular Pathogenesis, Graduate School of Medicine, Juntendo University, Tokyo, Japan

16Cancer Research (CR)-UK Stromal-Tumor Interaction Group, Paterson Institute for Cancer Research, The University of Manchester, Manchester, UK

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For correspondence: aorimo@juntendo.ac.jp

Published 22 July 2019. DOI: 10.26508/lsa.201900425

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CAFs and partial EMT in tumor clusters.

Yuko Matsumura, Yasuhiko Ito, Yoshihiro Mezawa, Kaidiliayi Sulidan, Yataro Daigo, Toru Hiraga, Kaoru Mogushi, Nadila Wali, Hiromu Suzuki, Takumi Itoh, Yohei Miyagi, Tomoyuki Yokose, Satoru Shimizu, Atsushi Takano, Yasuhisa Terao, Harumi Saeki, Masayuki Ozawa, Masaaki Abe, Satoru Takeda, Ko Okumura, Sonoko Habu, Okio Hino, Kazuyoshi Takeda, Michiaki Hamada, Akira Orimo

Life Science Alliance Jul 2019, 2 (4) e201900425; DOI: 10.26508/lsa.201900425

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CAFs and partial EMT in tumor clusters.

Life Science Alliance Jul 2019, 2 (4) e201900425; DOI: 10.26508/lsa.201900425

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