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Stromal fibroblasts induce metastatic tumor cell clusters via epithelial–mesenchymal plasticity

Yuko Matsumura, Yasuhiko Ito, Yoshihiro Mezawa, Kaidiliayi Sulidan, Yataro Daigo, View ORCID ProfileToru Hiraga, Kaoru Mogushi, Nadila Wali, Hiromu Suzuki, View ORCID ProfileTakumi Itoh, Yohei Miyagi, View ORCID ProfileTomoyuki Yokose, Satoru Shimizu, Atsushi Takano, Yasuhisa Terao, Harumi Saeki, Masayuki Ozawa, Masaaki Abe, Satoru Takeda, Ko Okumura, Sonoko Habu, Okio Hino, View ORCID ProfileKazuyoshi Takeda, View ORCID ProfileMichiaki Hamada, View ORCID ProfileAkira Orimo  Correspondence email
Yuko Matsumura
1Department of Molecular Pathogenesis, Graduate School of Medicine, Juntendo University, Tokyo, Japan
2Department of Obstetrics and Gynecology, Graduate School of Medicine, Juntendo University, Tokyo, Japan
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Yasuhiko Ito
1Department of Molecular Pathogenesis, Graduate School of Medicine, Juntendo University, Tokyo, Japan
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Yoshihiro Mezawa
1Department of Molecular Pathogenesis, Graduate School of Medicine, Juntendo University, Tokyo, Japan
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Kaidiliayi Sulidan
1Department of Molecular Pathogenesis, Graduate School of Medicine, Juntendo University, Tokyo, Japan
2Department of Obstetrics and Gynecology, Graduate School of Medicine, Juntendo University, Tokyo, Japan
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Yataro Daigo
12Center for Antibody and Vaccine Therapy, Research Hospital, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
13Department of Medical Oncology and Cancer Center, Shiga University of Medical Science, Otsu, Japan
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Toru Hiraga
7Department of Histology and Cell Biology, Matsumoto Dental University, Nagano, Japan
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  • ORCID record for Toru Hiraga
Kaoru Mogushi
8Intractable Disease Research Center, Graduate School of Medicine, Juntendo University, Tokyo, Japan
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Nadila Wali
1Department of Molecular Pathogenesis, Graduate School of Medicine, Juntendo University, Tokyo, Japan
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Hiromu Suzuki
15Department of Molecular Biology, School of Medicine, Sapporo Medical University, Hokkaido, Japan
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Takumi Itoh
1Department of Molecular Pathogenesis, Graduate School of Medicine, Juntendo University, Tokyo, Japan
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  • ORCID record for Takumi Itoh
Yohei Miyagi
9Molecular Pathology and Genetics Division, Kanagawa Cancer Center Research Institute, Yokohama, Japan
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Tomoyuki Yokose
10Department of Pathology, Kanagawa Cancer Center, Yokohama, Japan
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  • ORCID record for Tomoyuki Yokose
Satoru Shimizu
11Department of Breast and Endocrine Surgery, Kanagawa Cancer Center, Yokohama, Japan
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Atsushi Takano
12Center for Antibody and Vaccine Therapy, Research Hospital, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
13Department of Medical Oncology and Cancer Center, Shiga University of Medical Science, Otsu, Japan
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Yasuhisa Terao
2Department of Obstetrics and Gynecology, Graduate School of Medicine, Juntendo University, Tokyo, Japan
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Harumi Saeki
1Department of Molecular Pathogenesis, Graduate School of Medicine, Juntendo University, Tokyo, Japan
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Masayuki Ozawa
14Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan
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Masaaki Abe
1Department of Molecular Pathogenesis, Graduate School of Medicine, Juntendo University, Tokyo, Japan
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Satoru Takeda
2Department of Obstetrics and Gynecology, Graduate School of Medicine, Juntendo University, Tokyo, Japan
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Ko Okumura
4Atopy Research Center, Biomedical Research Center, Graduate School of Medicine, Juntendo University, Tokyo, Japan
6Department of Biofunctional Microbiota, Graduate School of Medicine, Juntendo University, Tokyo, Japan
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Sonoko Habu
4Atopy Research Center, Biomedical Research Center, Graduate School of Medicine, Juntendo University, Tokyo, Japan
6Department of Biofunctional Microbiota, Graduate School of Medicine, Juntendo University, Tokyo, Japan
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Okio Hino
1Department of Molecular Pathogenesis, Graduate School of Medicine, Juntendo University, Tokyo, Japan
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Kazuyoshi Takeda
5Division of Cell Biology, Biomedical Research Center, Graduate School of Medicine, Juntendo University, Tokyo, Japan
6Department of Biofunctional Microbiota, Graduate School of Medicine, Juntendo University, Tokyo, Japan
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Michiaki Hamada
3Department of Electrical Engineering and Bioscience, Faculty of Science and Engineering, Waseda University, Tokyo, Japan
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Akira Orimo
1Department of Molecular Pathogenesis, Graduate School of Medicine, Juntendo University, Tokyo, Japan
16Cancer Research (CR)-UK Stromal-Tumor Interaction Group, Paterson Institute for Cancer Research, The University of Manchester, Manchester, UK
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  • ORCID record for Akira Orimo
  • For correspondence: aorimo@juntendo.ac.jp
Published 22 July 2019. DOI: 10.26508/lsa.201900425
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Article Information

vol. 2 no. 4 e201900425
DOI 
https://doi.org/10.26508/lsa.201900425
PubMed 
31331982

Published By 
Life Science Alliance
Online ISSN 
2575-1077
History 
  • Received May 11, 2019
  • Revision received July 10, 2019
  • Accepted July 10, 2019
  • Published online July 22, 2019.

Copyright & Usage 
© 2019 Matsumura et al. This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).

Author Information

  1. Yuko Matsumura1,2,
  2. Yasuhiko Ito1,
  3. Yoshihiro Mezawa1,
  4. Kaidiliayi Sulidan1,2,
  5. Yataro Daigo12,13,
  6. Toru Hiraga7,
  7. Kaoru Mogushi8,
  8. Nadila Wali1,
  9. Hiromu Suzuki15,
  10. Takumi Itoh1,
  11. Yohei Miyagi9,
  12. Tomoyuki Yokose10,
  13. Satoru Shimizu11,
  14. Atsushi Takano12,13,
  15. Yasuhisa Terao2,
  16. Harumi Saeki1,
  17. Masayuki Ozawa14,
  18. Masaaki Abe1,
  19. Satoru Takeda2,
  20. Ko Okumura4,6,
  21. Sonoko Habu4,6,
  22. Okio Hino1,
  23. Kazuyoshi Takeda5,6,
  24. Michiaki Hamada3 and
  25. Akira Orimo1,16⇑
  1. 1Department of Molecular Pathogenesis, Graduate School of Medicine, Juntendo University, Tokyo, Japan
  2. 2Department of Obstetrics and Gynecology, Graduate School of Medicine, Juntendo University, Tokyo, Japan
  3. 3Department of Electrical Engineering and Bioscience, Faculty of Science and Engineering, Waseda University, Tokyo, Japan
  4. 4Atopy Research Center, Biomedical Research Center, Graduate School of Medicine, Juntendo University, Tokyo, Japan
  5. 5Division of Cell Biology, Biomedical Research Center, Graduate School of Medicine, Juntendo University, Tokyo, Japan
  6. 6Department of Biofunctional Microbiota, Graduate School of Medicine, Juntendo University, Tokyo, Japan
  7. 7Department of Histology and Cell Biology, Matsumoto Dental University, Nagano, Japan
  8. 8Intractable Disease Research Center, Graduate School of Medicine, Juntendo University, Tokyo, Japan
  9. 9Molecular Pathology and Genetics Division, Kanagawa Cancer Center Research Institute, Yokohama, Japan
  10. 10Department of Pathology, Kanagawa Cancer Center, Yokohama, Japan
  11. 11Department of Breast and Endocrine Surgery, Kanagawa Cancer Center, Yokohama, Japan
  12. 12Center for Antibody and Vaccine Therapy, Research Hospital, Institute of Medical Science, The University of Tokyo, Tokyo, Japan
  13. 13Department of Medical Oncology and Cancer Center, Shiga University of Medical Science, Otsu, Japan
  14. 14Graduate School of Medical and Dental Sciences, Kagoshima University, Kagoshima, Japan
  15. 15Department of Molecular Biology, School of Medicine, Sapporo Medical University, Hokkaido, Japan
  16. 16Cancer Research (CR)-UK Stromal-Tumor Interaction Group, Paterson Institute for Cancer Research, The University of Manchester, Manchester, UK
  1. Correspondence: aorimo{at}juntendo.ac.jp
View Full Text

Funding

  • JSPS KAKENHI

    16H06277
  • Cancer Research UK

    C147/A6058
    A Orimo
  • Ministry of Education, Culture, Sports, Science and Technology, Japan

    24300332; 25640069; 15K14385
    A Orimo
  • MEXT

    S1311011
    A Orimo
  • Juntendo University School of Medicine, Research Institute for Diseases of Old Age

    A Orimo
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CAFs and partial EMT in tumor clusters.
Yuko Matsumura, Yasuhiko Ito, Yoshihiro Mezawa, Kaidiliayi Sulidan, Yataro Daigo, Toru Hiraga, Kaoru Mogushi, Nadila Wali, Hiromu Suzuki, Takumi Itoh, Yohei Miyagi, Tomoyuki Yokose, Satoru Shimizu, Atsushi Takano, Yasuhisa Terao, Harumi Saeki, Masayuki Ozawa, Masaaki Abe, Satoru Takeda, Ko Okumura, Sonoko Habu, Okio Hino, Kazuyoshi Takeda, Michiaki Hamada, Akira Orimo
Life Science Alliance Jul 2019, 2 (4) e201900425; DOI: 10.26508/lsa.201900425

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CAFs and partial EMT in tumor clusters.
Yuko Matsumura, Yasuhiko Ito, Yoshihiro Mezawa, Kaidiliayi Sulidan, Yataro Daigo, Toru Hiraga, Kaoru Mogushi, Nadila Wali, Hiromu Suzuki, Takumi Itoh, Yohei Miyagi, Tomoyuki Yokose, Satoru Shimizu, Atsushi Takano, Yasuhisa Terao, Harumi Saeki, Masayuki Ozawa, Masaaki Abe, Satoru Takeda, Ko Okumura, Sonoko Habu, Okio Hino, Kazuyoshi Takeda, Michiaki Hamada, Akira Orimo
Life Science Alliance Jul 2019, 2 (4) e201900425; DOI: 10.26508/lsa.201900425
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Volume 2, No. 4
August 2019
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