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MITOL deletion in the brain impairs mitochondrial structure and ER tethering leading to oxidative stress

Shun Nagashima, Keisuke Takeda, Nobuhiko Ohno, Satoshi Ishido, Motohide Aoki, Yurika Saitoh, Takumi Takada, Takeshi Tokuyama, Ayumu Sugiura, Toshifumi Fukuda, Nobuko Matsushita, Ryoko Inatome, Shigeru Yanagi  Correspondence email
Published 15 August 2019. DOI: 10.26508/lsa.201900308

Article Information

vol. 2 no. 4 e201900308
DOI 
https://doi.org/10.26508/lsa.201900308
PubMed 
31416892
Published By 
Life Science Alliance
Online ISSN 
2575-1077
History 
  • Received January 16, 2019
  • Revision received August 1, 2019
  • Accepted August 1, 2019
  • Published online August 15, 2019.
Copyright & Usage 
© 2019 Nagashima et al. This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).

Author Information

  1. Shun Nagashima1,*,
  2. Keisuke Takeda1,*,
  3. Nobuhiko Ohno2,
  4. Satoshi Ishido3,
  5. Motohide Aoki4,
  6. Yurika Saitoh5,
  7. Takumi Takada1,
  8. Takeshi Tokuyama1,
  9. Ayumu Sugiura1,
  10. Toshifumi Fukuda1,
  11. Nobuko Matsushita1,
  12. Ryoko Inatome1 and
  13. Shigeru Yanagi1⇑
  1. 1Laboratory of Molecular Biochemistry, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo, Japan
  2. 2Department of Anatomy, Division of Histology and Cell Biology, School of Medicine, Jichi Medical University, Shimotsuke, Japan
  3. 3Department of Microbiology, Hyogo College of Medicine, Nishinomiya, Japan
  4. 4Laboratory of Bioanalytical and Environmental Chemistry, School of Life Sciences, Tokyo University of Pharmacy and Life Sciences, Hachioji, Tokyo, Japan
  5. 5Department of Tokyo Physical Therapy, Faculty of Medical Science, Teikyo University of Science, Adachi-ku, Tokyo, Japan
  1. Correspondence: syanagi{at}ls.toyaku.ac.jp

  1. ↵* Shun Nagashima and Keisuke Takeda contributed equally to this work.

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Funding

  • MEXT/JSPS KAKENHI

    18H04869; 15H01190; 17H04053; 16K15224; 16K08246
    S Nagashima, R Inatome, T Fukuda, S Yanagi

  • MEXT-Supported Program for the Strategic Research Foundation

    S1411014
    S Nagashima, R Inatome, S Yanagi

  • JSPS KAKENHI

    N Ohno

  • The Comprehensive Brain Science Network (CBSN)

    N Ohno

  • The Cooperative Study Programs of National Institute for Physiological Sciences

    N Ohno

  • The Uehara Memorial Foundation

    S Nagashima, S Yanagi

  • The Naito Foundation

    S Nagashima, S Yanagi

  • The Sumitomo Science Foundation

    S Yanagi

  • The Cosmetology Research Foundation

    S Yanagi

  • The Ono Medical Research Foundation

    S Yanagi

  • The Tokyo Biochemical Research Foundation

    S Yanagi

  • AMED

    JP17gm5010002; JP18gm5010002
    S Yanagi

  • Research Grant from National Center of Neurology and Psychiatry

    30-5
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MITOL regulates mitochondrial dynamics in brain
Shun Nagashima, Keisuke Takeda, Nobuhiko Ohno, Satoshi Ishido, Motohide Aoki, Yurika Saitoh, Takumi Takada, Takeshi Tokuyama, Ayumu Sugiura, Toshifumi Fukuda, Nobuko Matsushita, Ryoko Inatome, Shigeru Yanagi
Life Science Alliance Aug 2019, 2 (4) e201900308; DOI: 10.26508/lsa.201900308
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Volume 2, No. 4
August 2019
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