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Tumor-intrinsic response to IFNγ shapes the tumor microenvironment and anti–PD-1 response in NSCLC

View ORCID ProfileBonnie L Bullock, View ORCID ProfileAbigail K Kimball, Joanna M Poczobutt, Alexander J Neuwelt, View ORCID ProfileHoward Y Li, Amber M Johnson, Jeff W Kwak, View ORCID ProfileEmily K Kleczko, View ORCID ProfileRachael E Kaspar, Emily K Wagner, Katharina Hopp, View ORCID ProfileErin L Schenk, Mary CM Weiser-Evans, View ORCID ProfileEric T Clambey, View ORCID ProfileRaphael A Nemenoff  Correspondence email
Bonnie L Bullock
1Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA
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  • ORCID record for Bonnie L Bullock
Abigail K Kimball
2Department of Anesthesiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA
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  • ORCID record for Abigail K Kimball
Joanna M Poczobutt
1Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA
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Alexander J Neuwelt
1Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA
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Howard Y Li
1Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA
3Veterans Affairs Medical Center, Denver, CO, USA
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  • ORCID record for Howard Y Li
Amber M Johnson
1Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA
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Jeff W Kwak
1Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA
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Emily K Kleczko
1Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA
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  • ORCID record for Emily K Kleczko
Rachael E Kaspar
2Department of Anesthesiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA
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  • ORCID record for Rachael E Kaspar
Emily K Wagner
1Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA
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Katharina Hopp
1Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA
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Erin L Schenk
1Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA
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  • ORCID record for Erin L Schenk
Mary CM Weiser-Evans
1Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA
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Eric T Clambey
2Department of Anesthesiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA
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  • ORCID record for Eric T Clambey
Raphael A Nemenoff
1Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA
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  • ORCID record for Raphael A Nemenoff
  • For correspondence: raphael.nemenoff@ucdenver.edu
Published 27 May 2019. DOI: 10.26508/lsa.201900328
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Article Information

vol. 2 no. 3 e201900328
DOI 
https://doi.org/10.26508/lsa.201900328
PubMed 
31133614

Published By 
Life Science Alliance
Online ISSN 
2575-1077
History 
  • Received January 30, 2019
  • Revision received May 13, 2019
  • Accepted May 14, 2019
  • Published online May 27, 2019.

Copyright & Usage 
© 2019 Bullock et al. This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).

Author Information

  1. Bonnie L Bullock1,
  2. Abigail K Kimball2,
  3. Joanna M Poczobutt1,
  4. Alexander J Neuwelt1,
  5. Howard Y Li1,3,
  6. Amber M Johnson1,
  7. Jeff W Kwak1,
  8. Emily K Kleczko1,
  9. Rachael E Kaspar2,
  10. Emily K Wagner1,
  11. Katharina Hopp1,
  12. Erin L Schenk1,
  13. Mary CM Weiser-Evans1,
  14. Eric T Clambey2 and
  15. Raphael A Nemenoff1⇑
  1. 1Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA
  2. 2Department of Anesthesiology, University of Colorado Anschutz Medical Campus, Aurora, CO, USA
  3. 3Veterans Affairs Medical Center, Denver, CO, USA
  1. Correspondence: raphael.nemenoff{at}ucdenver.edu
View Full Text

Funding

  • National Institutes of Health

    R01 CA162226; CA236222
    RA Nemenoff
  • Colorado Lung SPORE

    P50 CA058187
    HY Li, RA Nemenoff
  • United States Department of Veterans Affairs Biomedical Laboratory Research and Development Service

    IK2BX001282
    HY Li
  • NIH/NCATS

    TL1 TR001081
    BL Bullock
  • NIH

    P30CA046934
  • National Cancer Institute

    P30CA046934
  • NIH/NCATS

    UL1 TR001082
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SOCS1 regulates immunotherapy in NSCLC
Bonnie L Bullock, Abigail K Kimball, Joanna M Poczobutt, Alexander J Neuwelt, Howard Y Li, Amber M Johnson, Jeff W Kwak, Emily K Kleczko, Rachael E Kaspar, Emily K Wagner, Katharina Hopp, Erin L Schenk, Mary CM Weiser-Evans, Eric T Clambey, Raphael A Nemenoff
Life Science Alliance May 2019, 2 (3) e201900328; DOI: 10.26508/lsa.201900328

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SOCS1 regulates immunotherapy in NSCLC
Bonnie L Bullock, Abigail K Kimball, Joanna M Poczobutt, Alexander J Neuwelt, Howard Y Li, Amber M Johnson, Jeff W Kwak, Emily K Kleczko, Rachael E Kaspar, Emily K Wagner, Katharina Hopp, Erin L Schenk, Mary CM Weiser-Evans, Eric T Clambey, Raphael A Nemenoff
Life Science Alliance May 2019, 2 (3) e201900328; DOI: 10.26508/lsa.201900328
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Volume 2, No. 3
June 2019
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