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Mesenchymal stromal cell activation by breast cancer secretomes in bioengineered 3D microenvironments

View ORCID ProfileUlrich Blache, View ORCID ProfileEdward R Horton, Tian Xia, Erwin M Schoof, Lene H Blicher, Angelina Schönenberger, Jess G Snedeker, Ivan Martin, Janine T Erler  Correspondence email, View ORCID ProfileMartin Ehrbar  Correspondence email
Ulrich Blache
1Department of Obstetrics, University and University Hospital of Zurich, Zurich, Switzerland
2Institute for Biomechanics, Eidgenössische Technische Hochschule Zurich, Zurich, Switzerland
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  • ORCID record for Ulrich Blache
Edward R Horton
3Biotech Research and Innovation Centre, University of Copenhagen, Copenhagen, Denmark
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  • ORCID record for Edward R Horton
Tian Xia
3Biotech Research and Innovation Centre, University of Copenhagen, Copenhagen, Denmark
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Erwin M Schoof
4Department of Biotechnology and Biomedicine, Technical University of Denmark, Lyngby, Denmark
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Lene H Blicher
4Department of Biotechnology and Biomedicine, Technical University of Denmark, Lyngby, Denmark
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Angelina Schönenberger
2Institute for Biomechanics, Eidgenössische Technische Hochschule Zurich, Zurich, Switzerland
5Biomechanics Laboratory, Balgrist University Hospital, University of Zurich, Zurich, Switzerland
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Jess G Snedeker
2Institute for Biomechanics, Eidgenössische Technische Hochschule Zurich, Zurich, Switzerland
5Biomechanics Laboratory, Balgrist University Hospital, University of Zurich, Zurich, Switzerland
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Ivan Martin
6Department of Biomedicine, University Hospital Basel, University of Basel, Basel, Switzerland
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Janine T Erler
3Biotech Research and Innovation Centre, University of Copenhagen, Copenhagen, Denmark
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  • For correspondence: janine.erler@bric.ku.dk
Martin Ehrbar
1Department of Obstetrics, University and University Hospital of Zurich, Zurich, Switzerland
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  • For correspondence: martin.ehrbar@usz.ch
Published 3 June 2019. DOI: 10.26508/lsa.201900304
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Article Information

vol. 2 no. 3 e201900304
DOI 
https://doi.org/10.26508/lsa.201900304
PubMed 
31160380

Published By 
Life Science Alliance
Online ISSN 
2575-1077
History 
  • Received January 14, 2019
  • Revision received May 22, 2019
  • Accepted May 22, 2019
  • Published online June 3, 2019.

Copyright & Usage 
© 2019 Blache et al. This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).

Author Information

  1. Ulrich Blache1,2,*,
  2. Edward R Horton3,*,
  3. Tian Xia3,
  4. Erwin M Schoof4,
  5. Lene H Blicher4,
  6. Angelina Schönenberger2,5,
  7. Jess G Snedeker2,5,
  8. Ivan Martin6,
  9. Janine T Erler3⇑ and
  10. Martin Ehrbar1⇑
  1. 1Department of Obstetrics, University and University Hospital of Zurich, Zurich, Switzerland
  2. 2Institute for Biomechanics, Eidgenössische Technische Hochschule Zurich, Zurich, Switzerland
  3. 3Biotech Research and Innovation Centre, University of Copenhagen, Copenhagen, Denmark
  4. 4Department of Biotechnology and Biomedicine, Technical University of Denmark, Lyngby, Denmark
  5. 5Biomechanics Laboratory, Balgrist University Hospital, University of Zurich, Zurich, Switzerland
  6. 6Department of Biomedicine, University Hospital Basel, University of Basel, Basel, Switzerland
  1. Correspondence: janine.erler{at}bric.ku.dk
  2. martin.ehrbar{at}usz.ch
  1. ↵* Ulrich Blache and Edward R Horton contributed equally to this work

View Full Text

Funding

  • European Research Council

    ERC-2015-CoG-682881-MATRICAN
  • European Molecular Biology Organization

    ATLF 922-2016
  • Danish Cancer Society

    R204-A12445
  • European Union's Seventh Framework Programme

    607868
  • Swiss National Science Foundation

    310030-169808/1
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MSC activation by cancer secretomes in 3D
Ulrich Blache, Edward R Horton, Tian Xia, Erwin M Schoof, Lene H Blicher, Angelina Schönenberger, Jess G Snedeker, Ivan Martin, Janine T Erler, Martin Ehrbar
Life Science Alliance Jun 2019, 2 (3) e201900304; DOI: 10.26508/lsa.201900304

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MSC activation by cancer secretomes in 3D
Ulrich Blache, Edward R Horton, Tian Xia, Erwin M Schoof, Lene H Blicher, Angelina Schönenberger, Jess G Snedeker, Ivan Martin, Janine T Erler, Martin Ehrbar
Life Science Alliance Jun 2019, 2 (3) e201900304; DOI: 10.26508/lsa.201900304
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Volume 2, No. 3
June 2019
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