Rate of brain aging and APOE ε4 are synergistic risk factors for Alzheimer’s disease

Christin A Glorioso; Andreas R Pfenning; Sam S Lee; David A Bennett; Etienne L Sibille; Manolis Kellis; Leonard P Guarente

doi:10.26508/lsa.201900303

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Rate of brain aging and APOE ε4 are synergistic risk factors for Alzheimer’s disease

View ORCID ProfileChristin A Glorioso Correspondence email, Andreas R Pfenning, View ORCID ProfileSam S Lee, David A Bennett, Etienne L Sibille, Manolis Kellis, View ORCID ProfileLeonard P Guarente Correspondence email

Christin A Glorioso

1Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA

2Paul F. Glenn Center for Biology of Aging Research at Massachusetts Institute of Technology, Cambridge, MA, USA

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ORCID record for Christin A Glorioso
For correspondence: glorioso@mit.edu

Andreas R Pfenning

3Department of Computational Biology, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA, USA

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Sam S Lee

1Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA

2Paul F. Glenn Center for Biology of Aging Research at Massachusetts Institute of Technology, Cambridge, MA, USA

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ORCID record for Sam S Lee

David A Bennett

4Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL, USA

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Etienne L Sibille

5Department of Psychiatry and of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada

6Campbell Family Mental Health Research Institute, Toronto, Ontario, Canada

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Manolis Kellis

7Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, USA

8The Broad Institute of Harvard and the Massachusetts Institute of Technology, Cambridge, MA, USA

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Leonard P Guarente

1Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA

2Paul F. Glenn Center for Biology of Aging Research at Massachusetts Institute of Technology, Cambridge, MA, USA

9The Koch Institute, Massachusetts Institute of Technology, Cambridge, MA, USA

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ORCID record for Leonard P Guarente
For correspondence: leng@mit.edu

Published 27 May 2019. DOI: 10.26508/lsa.201900303

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Brain aging and APOE ε4 synergize risk of Alzheimer

Christin A Glorioso, Andreas R Pfenning, Sam S Lee, David A Bennett, Etienne L Sibille, Manolis Kellis, Leonard P Guarente

Life Science Alliance May 2019, 2 (3) e201900303; DOI: 10.26508/lsa.201900303

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Brain aging and APOE ε4 synergize risk of Alzheimer

Christin A Glorioso, Andreas R Pfenning, Sam S Lee, David A Bennett, Etienne L Sibille, Manolis Kellis, Leonard P Guarente

Life Science Alliance May 2019, 2 (3) e201900303; DOI: 10.26508/lsa.201900303

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