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Research Article
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Rate of brain aging and APOE ε4 are synergistic risk factors for Alzheimer’s disease

View ORCID ProfileChristin A Glorioso  Correspondence email, Andreas R Pfenning, View ORCID ProfileSam S Lee, David A Bennett, Etienne L Sibille, Manolis Kellis, View ORCID ProfileLeonard P Guarente  Correspondence email
Christin A Glorioso
1Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA
2Paul F. Glenn Center for Biology of Aging Research at Massachusetts Institute of Technology, Cambridge, MA, USA
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  • ORCID record for Christin A Glorioso
  • For correspondence: glorioso@mit.edu
Andreas R Pfenning
3Department of Computational Biology, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA, USA
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Sam S Lee
1Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA
2Paul F. Glenn Center for Biology of Aging Research at Massachusetts Institute of Technology, Cambridge, MA, USA
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David A Bennett
4Rush Alzheimer’s Disease Center, Rush University Medical Center, Chicago, IL, USA
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Etienne L Sibille
5Department of Psychiatry and of Pharmacology and Toxicology, University of Toronto, Toronto, Ontario, Canada
6Campbell Family Mental Health Research Institute, Toronto, Ontario, Canada
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Manolis Kellis
7Computer Science and Artificial Intelligence Laboratory, Massachusetts Institute of Technology, Cambridge, MA, USA
8The Broad Institute of Harvard and the Massachusetts Institute of Technology, Cambridge, MA, USA
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Leonard P Guarente
1Department of Biology, Massachusetts Institute of Technology, Cambridge, MA, USA
2Paul F. Glenn Center for Biology of Aging Research at Massachusetts Institute of Technology, Cambridge, MA, USA
9The Koch Institute, Massachusetts Institute of Technology, Cambridge, MA, USA
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  • ORCID record for Leonard P Guarente
  • For correspondence: leng@mit.edu
Published 27 May 2019. DOI: 10.26508/lsa.201900303
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Brain aging and APOE ε4 synergize risk of Alzheimer
Christin A Glorioso, Andreas R Pfenning, Sam S Lee, David A Bennett, Etienne L Sibille, Manolis Kellis, Leonard P Guarente
Life Science Alliance May 2019, 2 (3) e201900303; DOI: 10.26508/lsa.201900303

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Brain aging and APOE ε4 synergize risk of Alzheimer
Christin A Glorioso, Andreas R Pfenning, Sam S Lee, David A Bennett, Etienne L Sibille, Manolis Kellis, Leonard P Guarente
Life Science Alliance May 2019, 2 (3) e201900303; DOI: 10.26508/lsa.201900303
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Volume 2, No. 3
June 2019
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