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Research Article
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Expression of a constitutively active human STING mutant in hematopoietic cells produces an Ifnar1-dependent vasculopathy in mice

View ORCID ProfileGary R Martin  Correspondence email, View ORCID ProfileKimiora Henare, Carolina Salazar, Teresa Scheidl-Yee, Laura J Eggen, Pankaj P Tailor, Jung Hwan Kim, John Podstawka, Marvin J Fritzler, Margaret M Kelly, Bryan G Yipp, View ORCID ProfileFrank R Jirik  Correspondence email
Gary R Martin
1Department of Biochemistry and Molecular Biology, Cumming School of Medicine, University of Calgary, Calgary, Canada
2The McCaig Institute for Bone and Joint Health, Cumming School of Medicine, University of Calgary, Calgary, Canada
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  • ORCID record for Gary R Martin
  • For correspondence: marting@ucalgary.ca
Kimiora Henare
1Department of Biochemistry and Molecular Biology, Cumming School of Medicine, University of Calgary, Calgary, Canada
2The McCaig Institute for Bone and Joint Health, Cumming School of Medicine, University of Calgary, Calgary, Canada
6Auckland Cancer Society Research Centre, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand
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  • ORCID record for Kimiora Henare
Carolina Salazar
1Department of Biochemistry and Molecular Biology, Cumming School of Medicine, University of Calgary, Calgary, Canada
2The McCaig Institute for Bone and Joint Health, Cumming School of Medicine, University of Calgary, Calgary, Canada
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Teresa Scheidl-Yee
1Department of Biochemistry and Molecular Biology, Cumming School of Medicine, University of Calgary, Calgary, Canada
2The McCaig Institute for Bone and Joint Health, Cumming School of Medicine, University of Calgary, Calgary, Canada
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Laura J Eggen
1Department of Biochemistry and Molecular Biology, Cumming School of Medicine, University of Calgary, Calgary, Canada
2The McCaig Institute for Bone and Joint Health, Cumming School of Medicine, University of Calgary, Calgary, Canada
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Pankaj P Tailor
1Department of Biochemistry and Molecular Biology, Cumming School of Medicine, University of Calgary, Calgary, Canada
2The McCaig Institute for Bone and Joint Health, Cumming School of Medicine, University of Calgary, Calgary, Canada
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Jung Hwan Kim
4Department of Critical Care Medicine, Cumming School of Medicine, University of Calgary, Calgary, Canada
5Calvin, Phoebe and Joan Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Canada
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John Podstawka
5Calvin, Phoebe and Joan Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Canada
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Marvin J Fritzler
1Department of Biochemistry and Molecular Biology, Cumming School of Medicine, University of Calgary, Calgary, Canada
2The McCaig Institute for Bone and Joint Health, Cumming School of Medicine, University of Calgary, Calgary, Canada
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Margaret M Kelly
3Department of Pathology and Laboratory Medicine, Cumming School of Medicine, University of Calgary, Calgary, Canada
5Calvin, Phoebe and Joan Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Canada
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Bryan G Yipp
4Department of Critical Care Medicine, Cumming School of Medicine, University of Calgary, Calgary, Canada
5Calvin, Phoebe and Joan Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Canada
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Frank R Jirik
1Department of Biochemistry and Molecular Biology, Cumming School of Medicine, University of Calgary, Calgary, Canada
2The McCaig Institute for Bone and Joint Health, Cumming School of Medicine, University of Calgary, Calgary, Canada
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  • ORCID record for Frank R Jirik
  • For correspondence: jirik@ucalgary.ca
Published 20 June 2019. DOI: 10.26508/lsa.201800215
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Article Information

vol. 2 no. 3 e201800215
DOI 
https://doi.org/10.26508/lsa.201800215
PubMed 
31221625

Published By 
Life Science Alliance
Online ISSN 
2575-1077
History 
  • Received October 11, 2018
  • Revision received June 11, 2019
  • Accepted June 12, 2019
  • Published online June 20, 2019.

Copyright & Usage 
© 2019 Martin et al. This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).

Author Information

  1. Gary R Martin1,2⇑,
  2. Kimiora Henare1,2,6,
  3. Carolina Salazar1,2,
  4. Teresa Scheidl-Yee1,2,
  5. Laura J Eggen1,2,
  6. Pankaj P Tailor1,2,
  7. Jung Hwan Kim4,5,
  8. John Podstawka5,
  9. Marvin J Fritzler1,2,
  10. Margaret M Kelly3,5,
  11. Bryan G Yipp4,5 and
  12. Frank R Jirik1,2⇑
  1. 1Department of Biochemistry and Molecular Biology, Cumming School of Medicine, University of Calgary, Calgary, Canada
  2. 2The McCaig Institute for Bone and Joint Health, Cumming School of Medicine, University of Calgary, Calgary, Canada
  3. 3Department of Pathology and Laboratory Medicine, Cumming School of Medicine, University of Calgary, Calgary, Canada
  4. 4Department of Critical Care Medicine, Cumming School of Medicine, University of Calgary, Calgary, Canada
  5. 5Calvin, Phoebe and Joan Snyder Institute for Chronic Diseases, Cumming School of Medicine, University of Calgary, Calgary, Canada
  6. 6Auckland Cancer Society Research Centre, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand
  1. Correspondence: marting{at}ucalgary.ca
  2. jirik{at}ucalgary.ca
View Full Text

Funding

  • University of Auckland

    15/446
    K Henare
  • Tier II Canada Research Chair in Pulmonary Immunology, Inflammation and Host Defense

    BG Yipp
  • Canadian Institutes for Health Research

    FR Jirik
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Expression of a constitutively active human STING mutant in hematopoietic cells produces an Ifnar1-dependent vasculopathy in mice
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Transgenic model of STING-associated vasculopathy
Gary R Martin, Kimiora Henare, Carolina Salazar, Teresa Scheidl-Yee, Laura J Eggen, Pankaj P Tailor, Jung Hwan Kim, John Podstawka, Marvin J Fritzler, Margaret M Kelly, Bryan G Yipp, Frank R Jirik
Life Science Alliance Jun 2019, 2 (3) e201800215; DOI: 10.26508/lsa.201800215

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Transgenic model of STING-associated vasculopathy
Gary R Martin, Kimiora Henare, Carolina Salazar, Teresa Scheidl-Yee, Laura J Eggen, Pankaj P Tailor, Jung Hwan Kim, John Podstawka, Marvin J Fritzler, Margaret M Kelly, Bryan G Yipp, Frank R Jirik
Life Science Alliance Jun 2019, 2 (3) e201800215; DOI: 10.26508/lsa.201800215
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Volume 2, No. 3
June 2019
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