Gene editing enables T-cell engineering to redirect antigen specificity for potent tumor rejection

Julian J Albers; Tim Ammon; Dario Gosmann; Stefan Audehm; Silvia Thoene; Christof Winter; Ramona Secci; Anja Wolf; Anja Stelzl; Katja Steiger; Jürgen Ruland; Florian Bassermann; Christian Kupatt; Martina Anton; Angela M Krackhardt

doi:10.26508/lsa.201900367

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Gene editing enables T-cell engineering to redirect antigen specificity for potent tumor rejection

Julian J Albers, Tim Ammon, Dario Gosmann, Stefan Audehm, Silvia Thoene, View ORCID ProfileChristof Winter, Ramona Secci, Anja Wolf, Anja Stelzl, Katja Steiger, Jürgen Ruland, Florian Bassermann, Christian Kupatt, Martina Anton, View ORCID ProfileAngela M Krackhardt Correspondence email

Julian J Albers

1Klinik und Poliklinik für Innere Medizin III, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany

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Tim Ammon

2Experimental Hematology Group, Klinik und Poliklinik für Innere Medizin III, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany

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Dario Gosmann

1Klinik und Poliklinik für Innere Medizin III, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany

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Stefan Audehm

1Klinik und Poliklinik für Innere Medizin III, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany

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Silvia Thoene

3Institut für Klinische Chemie und Pathobiochemie, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany

4German Cancer Consortium (DKTK), Partner-site Munich and German Cancer Research Center (DKFZ), Heidelberg, Germany

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Christof Winter

3Institut für Klinische Chemie und Pathobiochemie, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany

4German Cancer Consortium (DKTK), Partner-site Munich and German Cancer Research Center (DKFZ), Heidelberg, Germany

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ORCID record for Christof Winter

Ramona Secci

3Institut für Klinische Chemie und Pathobiochemie, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany

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Anja Wolf

5Klinik und Poliklinik für Innere Medizin I, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany

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Anja Stelzl

1Klinik und Poliklinik für Innere Medizin III, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany

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Katja Steiger

6Institut für Allgemeine Pathologie und Pathologische Anatomie, Technische Universität München, Munich, Germany

4German Cancer Consortium (DKTK), Partner-site Munich and German Cancer Research Center (DKFZ), Heidelberg, Germany

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Jürgen Ruland

3Institut für Klinische Chemie und Pathobiochemie, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany

4German Cancer Consortium (DKTK), Partner-site Munich and German Cancer Research Center (DKFZ), Heidelberg, Germany

7German Center for Infection Research (DZIF), Partner Site Munich, Munich, Germany

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Florian Bassermann

1Klinik und Poliklinik für Innere Medizin III, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany

4German Cancer Consortium (DKTK), Partner-site Munich and German Cancer Research Center (DKFZ), Heidelberg, Germany

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Christian Kupatt

5Klinik und Poliklinik für Innere Medizin I, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany

8German Center for Cardiovascular Research (DZHK), Partner-Site Munich Heart Alliance, Munich, Germany

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Martina Anton

9Institut für Molekulare Immunologie und Experimentelle Onkologie und Therapieforschung, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany

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Angela M Krackhardt

1Klinik und Poliklinik für Innere Medizin III, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany

4German Cancer Consortium (DKTK), Partner-site Munich and German Cancer Research Center (DKFZ), Heidelberg, Germany

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ORCID record for Angela M Krackhardt
For correspondence: angela.krackhardt@tum.de

Published 15 March 2019. DOI: 10.26508/lsa.201900367

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TCR knock-in redirects T cells against tumors

Julian J Albers, Tim Ammon, Dario Gosmann, Stefan Audehm, Silvia Thoene, Christof Winter, Ramona Secci, Anja Wolf, Anja Stelzl, Katja Steiger, Jürgen Ruland, Florian Bassermann, Christian Kupatt, Martina Anton, Angela M Krackhardt

Life Science Alliance Mar 2019, 2 (2) e201900367; DOI: 10.26508/lsa.201900367

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TCR knock-in redirects T cells against tumors

Life Science Alliance Mar 2019, 2 (2) e201900367; DOI: 10.26508/lsa.201900367

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