m6A-mRNA methylation regulates cardiac gene expression and cellular growth

Vivien Kmietczyk; Eva Riechert; Laura Kalinski; Etienne Boileau; Ellen Malovrh; Brandon Malone; Agnieszka Gorska; Christoph Hofmann; Eshita Varma; Lonny Jürgensen; Verena Kamuf-Schenk; Janine Altmüller; Rewati Tappu; Martin Busch; Patrick Most; Hugo A Katus; Christoph Dieterich; Mirko Völkers

doi:10.26508/lsa.201800233

Research Article

Open Access

m⁶A-mRNA methylation regulates cardiac gene expression and cellular growth

View ORCID ProfileVivien Kmietczyk, View ORCID ProfileEva Riechert, Laura Kalinski, View ORCID ProfileEtienne Boileau, View ORCID ProfileEllen Malovrh, Brandon Malone, Agnieszka Gorska, View ORCID ProfileChristoph Hofmann, Eshita Varma, Lonny Jürgensen, Verena Kamuf-Schenk, Janine Altmüller, Rewati Tappu, View ORCID ProfileMartin Busch, Patrick Most, Hugo A Katus, Christoph Dieterich, View ORCID ProfileMirko Völkers Correspondence email

Vivien Kmietczyk

1Department of Cardiology, Angiology, and Pneumology, University Hospital Heidelberg, University of Heidelberg, Heidelberg, Germany

2DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim, Heidelberg, Germany

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ORCID record for Vivien Kmietczyk

Eva Riechert

1Department of Cardiology, Angiology, and Pneumology, University Hospital Heidelberg, University of Heidelberg, Heidelberg, Germany

2DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim, Heidelberg, Germany

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Laura Kalinski

1Department of Cardiology, Angiology, and Pneumology, University Hospital Heidelberg, University of Heidelberg, Heidelberg, Germany

2DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim, Heidelberg, Germany

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Etienne Boileau

1Department of Cardiology, Angiology, and Pneumology, University Hospital Heidelberg, University of Heidelberg, Heidelberg, Germany

2DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim, Heidelberg, Germany

3Section of Bioinformatics and Systems Cardiology, Department of Cardiology, Angiology, and Pneumology and Klaus Tschira Institute for Integrative Computational Cardiology, University of Heidelberg, Heidelberg, Germany

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Ellen Malovrh

1Department of Cardiology, Angiology, and Pneumology, University Hospital Heidelberg, University of Heidelberg, Heidelberg, Germany

2DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim, Heidelberg, Germany

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Brandon Malone

1Department of Cardiology, Angiology, and Pneumology, University Hospital Heidelberg, University of Heidelberg, Heidelberg, Germany

2DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim, Heidelberg, Germany

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Agnieszka Gorska

1Department of Cardiology, Angiology, and Pneumology, University Hospital Heidelberg, University of Heidelberg, Heidelberg, Germany

2DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim, Heidelberg, Germany

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Christoph Hofmann

1Department of Cardiology, Angiology, and Pneumology, University Hospital Heidelberg, University of Heidelberg, Heidelberg, Germany

2DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim, Heidelberg, Germany

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Eshita Varma

1Department of Cardiology, Angiology, and Pneumology, University Hospital Heidelberg, University of Heidelberg, Heidelberg, Germany

2DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim, Heidelberg, Germany

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Lonny Jürgensen

1Department of Cardiology, Angiology, and Pneumology, University Hospital Heidelberg, University of Heidelberg, Heidelberg, Germany

2DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim, Heidelberg, Germany

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Verena Kamuf-Schenk

1Department of Cardiology, Angiology, and Pneumology, University Hospital Heidelberg, University of Heidelberg, Heidelberg, Germany

2DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim, Heidelberg, Germany

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Janine Altmüller

4Cologne Center for Genomics, University Cologne, Cologne, Germany

5Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany

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Rewati Tappu

1Department of Cardiology, Angiology, and Pneumology, University Hospital Heidelberg, University of Heidelberg, Heidelberg, Germany

2DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim, Heidelberg, Germany

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Martin Busch

1Department of Cardiology, Angiology, and Pneumology, University Hospital Heidelberg, University of Heidelberg, Heidelberg, Germany

2DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim, Heidelberg, Germany

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Patrick Most

1Department of Cardiology, Angiology, and Pneumology, University Hospital Heidelberg, University of Heidelberg, Heidelberg, Germany

2DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim, Heidelberg, Germany

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Hugo A Katus

1Department of Cardiology, Angiology, and Pneumology, University Hospital Heidelberg, University of Heidelberg, Heidelberg, Germany

2DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim, Heidelberg, Germany

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Christoph Dieterich

1Department of Cardiology, Angiology, and Pneumology, University Hospital Heidelberg, University of Heidelberg, Heidelberg, Germany

2DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim, Heidelberg, Germany

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Mirko Völkers

1Department of Cardiology, Angiology, and Pneumology, University Hospital Heidelberg, University of Heidelberg, Heidelberg, Germany

2DZHK (German Centre for Cardiovascular Research), Partner Site Heidelberg/Mannheim, Heidelberg, Germany

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ORCID record for Mirko Völkers
For correspondence: mirko.voelkers@med.uni-heidelberg.de

Published 9 April 2019. DOI: 10.26508/lsa.201800233

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Citation Tools

mRNA methylation in the myocardium

Vivien Kmietczyk, Eva Riechert, Laura Kalinski, Etienne Boileau, Ellen Malovrh, Brandon Malone, Agnieszka Gorska, Christoph Hofmann, Eshita Varma, Lonny Jürgensen, Verena Kamuf-Schenk, Janine Altmüller, Rewati Tappu, Martin Busch, Patrick Most, Hugo A Katus, Christoph Dieterich, Mirko Völkers

Life Science Alliance Apr 2019, 2 (2) e201800233; DOI: 10.26508/lsa.201800233