Reciprocal regulation of STING and TCR signaling by mTORC1 for T-cell activation and function

Takayuki Imanishi; Midori Unno; Wakana Kobayashi; Natsumi Yoneda; Satoshi Matsuda; Kazutaka Ikeda; Takayuki Hoshii; Atsushi Hirao; Kensuke Miyake; Glen N Barber; Makoto Arita; Ken J Ishii; Shizuo Akira; Takashi Saito

doi:10.26508/lsa.201800282

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Reciprocal regulation of STING and TCR signaling by mTORC1 for T-cell activation and function

Takayuki Imanishi Correspondence email, Midori Unno, Wakana Kobayashi, Natsumi Yoneda, Satoshi Matsuda, Kazutaka Ikeda, Takayuki Hoshii, Atsushi Hirao, Kensuke Miyake, Glen N Barber, Makoto Arita, Ken J Ishii, Shizuo Akira, View ORCID ProfileTakashi Saito Correspondence email

Takayuki Imanishi

1Laboratory for Cell Signaling, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan

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For correspondence: takayuki.imanishi@riken.jp

Midori Unno

1Laboratory for Cell Signaling, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan

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Wakana Kobayashi

1Laboratory for Cell Signaling, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan

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Natsumi Yoneda

1Laboratory for Cell Signaling, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan

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Satoshi Matsuda

2Department of Cell Signaling, Institute of Biomedical Sciences, Kansai Medical University, Hirakata, Japan

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Kazutaka Ikeda

3Laboratory for Metabolomics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan

4Japan Agency for Medical Research and Development (AMED)-PRIME, Japan Agency for Medical Research and Development, Tokyo, Japan

5Graduate School of Medical Life Science, Yokohama City University, Yokohama, Japan

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Takayuki Hoshii

6Division of Molecular Genetics, Cancer Research Institute, Kanazawa University, Kanazawa, Japan

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Atsushi Hirao

6Division of Molecular Genetics, Cancer Research Institute, Kanazawa University, Kanazawa, Japan

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Kensuke Miyake

7Division of Innate Immunity, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan

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Glen N Barber

8Department of Cell Biology and the Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA

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Makoto Arita

3Laboratory for Metabolomics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan

5Graduate School of Medical Life Science, Yokohama City University, Yokohama, Japan

9Division of Physiological Chemistry and Metabolism, Graduate School of Pharmaceutical Sciences, Keio University, Tokyo, Japan

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Ken J Ishii

10Laboratory of Vaccine Science, World Premier International Research Center Initiative (WPI) Immunology Frontier Research Center, Osaka University, Suita, Japan

11Laboratory of Adjuvant Innovation, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka, Japan

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Shizuo Akira

12Laboratory of Host Defense, WPI Immunology Frontier Research Center, Osaka University, Osaka, Japan

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Takashi Saito

1Laboratory for Cell Signaling, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan

13Laboratory for Cell Signaling, WPI Immunology Frontier Research Center, Osaka University, Osaka, Japan

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ORCID record for Takashi Saito
For correspondence: takashi.saito@riken.jp

Published 25 January 2019. DOI: 10.26508/lsa.201800282

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Critical role of mTOR in STING-mediated responses in T cells

Takayuki Imanishi, Midori Unno, Wakana Kobayashi, Natsumi Yoneda, Satoshi Matsuda, Kazutaka Ikeda, Takayuki Hoshii, Atsushi Hirao, Kensuke Miyake, Glen N Barber, Makoto Arita, Ken J Ishii, Shizuo Akira, Takashi Saito

Life Science Alliance Jan 2019, 2 (1) e201800282; DOI: 10.26508/lsa.201800282

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Critical role of mTOR in STING-mediated responses in T cells

Life Science Alliance Jan 2019, 2 (1) e201800282; DOI: 10.26508/lsa.201800282

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