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Reciprocal regulation of STING and TCR signaling by mTORC1 for T-cell activation and function

Takayuki Imanishi  Correspondence email, Midori Unno, Wakana Kobayashi, Natsumi Yoneda, Satoshi Matsuda, Kazutaka Ikeda, Takayuki Hoshii, Atsushi Hirao, Kensuke Miyake, Glen N Barber, Makoto Arita, Ken J Ishii, Shizuo Akira, Takashi Saito  Correspondence email
Published 25 January 2019. DOI: 10.26508/lsa.201800282

Article Information

vol. 2 no. 1 e201800282
DOI 
https://doi.org/10.26508/lsa.201800282
PubMed 
30683688
Published By 
Life Science Alliance
Online ISSN 
2575-1077
History 
  • Received December 17, 2018
  • Revision received December 26, 2018
  • Accepted January 7, 2019
  • Published online January 25, 2019.
Copyright & Usage 
© 2019 Imanishi et al. This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).

Author Information

  1. Takayuki Imanishi1⇑,
  2. Midori Unno1,
  3. Wakana Kobayashi1,
  4. Natsumi Yoneda1,
  5. Satoshi Matsuda2,
  6. Kazutaka Ikeda3,4,5,
  7. Takayuki Hoshii6,
  8. Atsushi Hirao6,
  9. Kensuke Miyake7,
  10. Glen N Barber8,
  11. Makoto Arita3,5,9,
  12. Ken J Ishii10,11,
  13. Shizuo Akira12 and
  14. Takashi Saito1,13⇑
  1. 1Laboratory for Cell Signaling, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan
  2. 2Department of Cell Signaling, Institute of Biomedical Sciences, Kansai Medical University, Hirakata, Japan
  3. 3Laboratory for Metabolomics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan
  4. 4Japan Agency for Medical Research and Development (AMED)-PRIME, Japan Agency for Medical Research and Development, Tokyo, Japan
  5. 5Graduate School of Medical Life Science, Yokohama City University, Yokohama, Japan
  6. 6Division of Molecular Genetics, Cancer Research Institute, Kanazawa University, Kanazawa, Japan
  7. 7Division of Innate Immunity, Department of Microbiology and Immunology, Institute of Medical Science, University of Tokyo, Tokyo, Japan
  8. 8Department of Cell Biology and the Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA
  9. 9Division of Physiological Chemistry and Metabolism, Graduate School of Pharmaceutical Sciences, Keio University, Tokyo, Japan
  10. 10Laboratory of Vaccine Science, World Premier International Research Center Initiative (WPI) Immunology Frontier Research Center, Osaka University, Suita, Japan
  11. 11Laboratory of Adjuvant Innovation, National Institutes of Biomedical Innovation, Health and Nutrition, Osaka, Japan
  12. 12Laboratory of Host Defense, WPI Immunology Frontier Research Center, Osaka University, Osaka, Japan
  13. 13Laboratory for Cell Signaling, WPI Immunology Frontier Research Center, Osaka University, Osaka, Japan
  1. Correspondence: takashi.saito{at}riken.jp
  2. takayuki.imanishi{at}riken.jp

  • Wakana Kobayashi’s present address is Laboratory for Mucosal Immunity, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan.

  • Takayuki Hoshii's present address is Department of Pediatric Oncology, Dana-Farber Cancer Institute and Division of Hematology/Oncology, Boston Children's Hospital, Harvard Medical School, Boston, USA and Center for Epigenetics Research, Memorial Sloan Kettering Cancer Center, New York, USA

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Funding

  • Grant-in-Aid for Scientific Research from the Japan Society for the Promotion of Science KAKENHI

    16K08852
    T Imanishi
  • 24229004
    T Saito
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Critical role of mTOR in STING-mediated responses in T cells
Takayuki Imanishi, Midori Unno, Wakana Kobayashi, Natsumi Yoneda, Satoshi Matsuda, Kazutaka Ikeda, Takayuki Hoshii, Atsushi Hirao, Kensuke Miyake, Glen N Barber, Makoto Arita, Ken J Ishii, Shizuo Akira, Takashi Saito
Life Science Alliance Jan 2019, 2 (1) e201800282; DOI: 10.26508/lsa.201800282
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Volume 2, No. 1
February 2019
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