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Folding–function relationship of the most common cystic fibrosis–causing CFTR conductance mutants

Marcel van Willigen, Annelotte M Vonk, Hui Ying Yeoh, Evelien Kruisselbrink, Bertrand Kleizen, Cornelis K van der Ent, Maarten R Egmond, Hugo R de Jonge, View ORCID ProfileIneke Braakman, Jeffrey M Beekman, View ORCID ProfilePeter van der Sluijs  Correspondence email
Marcel van Willigen
1Cellular Protein Chemistry, Department of Chemistry, Utrecht University, Utrecht, The Netherlands
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Annelotte M Vonk
2Department of Pediatric Pulmonology, Wilhelmina Children's Hospital, University Medical Center, Utrecht, The Netherlands
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Hui Ying Yeoh
1Cellular Protein Chemistry, Department of Chemistry, Utrecht University, Utrecht, The Netherlands
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Evelien Kruisselbrink
2Department of Pediatric Pulmonology, Wilhelmina Children's Hospital, University Medical Center, Utrecht, The Netherlands
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Bertrand Kleizen
1Cellular Protein Chemistry, Department of Chemistry, Utrecht University, Utrecht, The Netherlands
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Cornelis K van der Ent
2Department of Pediatric Pulmonology, Wilhelmina Children's Hospital, University Medical Center, Utrecht, The Netherlands
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Maarten R Egmond
1Cellular Protein Chemistry, Department of Chemistry, Utrecht University, Utrecht, The Netherlands
3Membrane Biochemistry and Biophysics, Department of Chemistry, Utrecht University, Utrecht, The Netherlands
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Hugo R de Jonge
4Department of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, The Netherlands
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Ineke Braakman
1Cellular Protein Chemistry, Department of Chemistry, Utrecht University, Utrecht, The Netherlands
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  • ORCID record for Ineke Braakman
Jeffrey M Beekman
2Department of Pediatric Pulmonology, Wilhelmina Children's Hospital, University Medical Center, Utrecht, The Netherlands
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Peter van der Sluijs
1Cellular Protein Chemistry, Department of Chemistry, Utrecht University, Utrecht, The Netherlands
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  • ORCID record for Peter van der Sluijs
  • For correspondence: p.vandersluijs1@uu.nl
Published 18 January 2019. DOI: 10.26508/lsa.201800172
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Article Information

vol. 2 no. 1 e201800172
DOI 
https://doi.org/10.26508/lsa.201800172
PubMed 
30659068

Published By 
Life Science Alliance
Online ISSN 
2575-1077
History 
  • Received August 24, 2018
  • Revision received January 9, 2019
  • Accepted January 10, 2019
  • Published online January 18, 2019.

Copyright & Usage 
© 2019 van Willigen et al. This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).

Author Information

  1. Marcel van Willigen1,
  2. Annelotte M Vonk2,
  3. Hui Ying Yeoh1,
  4. Evelien Kruisselbrink2,
  5. Bertrand Kleizen1,
  6. Cornelis K van der Ent2,
  7. Maarten R Egmond1,3,
  8. Hugo R de Jonge4,
  9. Ineke Braakman1,
  10. Jeffrey M Beekman2 and
  11. Peter van der Sluijs1⇑
  1. 1Cellular Protein Chemistry, Department of Chemistry, Utrecht University, Utrecht, The Netherlands
  2. 2Department of Pediatric Pulmonology, Wilhelmina Children's Hospital, University Medical Center, Utrecht, The Netherlands
  3. 3Membrane Biochemistry and Biophysics, Department of Chemistry, Utrecht University, Utrecht, The Netherlands
  4. 4Department of Gastroenterology and Hepatology, Erasmus University Medical Center, Rotterdam, The Netherlands
  1. Correspondence: p.vandersluijs1{at}uu.nl
View Full Text

Funding

  • Netherlands Organization for Health Research and Development

    40-00812-98-14103
    CK van der Ent, J Beekman, I Braakman
  • Netherlands Cystic Fibrosis Foundation

    HIT-CF
  • Cystic Fibrosis Foundation

    BRAAKM14XX0
    I Braakman
  • Vertex Pharmaceuticals, Gilead, Galapagos

    CK van der Ent
  • ProQR, and Teva Pharmaceuticals

    CK van der Ent
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Folding–function relationship of CF mutants
Marcel van Willigen, Annelotte M Vonk, Hui Ying Yeoh, Evelien Kruisselbrink, Bertrand Kleizen, Cornelis K van der Ent, Maarten R Egmond, Hugo R de Jonge, Ineke Braakman, Jeffrey M Beekman, Peter van der Sluijs
Life Science Alliance Jan 2019, 2 (1) e201800172; DOI: 10.26508/lsa.201800172

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Folding–function relationship of CF mutants
Marcel van Willigen, Annelotte M Vonk, Hui Ying Yeoh, Evelien Kruisselbrink, Bertrand Kleizen, Cornelis K van der Ent, Maarten R Egmond, Hugo R de Jonge, Ineke Braakman, Jeffrey M Beekman, Peter van der Sluijs
Life Science Alliance Jan 2019, 2 (1) e201800172; DOI: 10.26508/lsa.201800172
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Volume 2, No. 1
February 2019
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