Variants of DNMT3A cause transcript-specific DNA methylation patterns and affect hematopoiesis

Tanja Božić; Joana Frobel; Annamarija Raic; Fabio Ticconi; Chao-Chung Kuo; Stefanie Heilmann-Heimbach; Tamme W Goecke; Martin Zenke; Edgar Jost; Ivan G Costa; Wolfgang Wagner

doi:10.26508/lsa.201800153

Research Article

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Variants of DNMT3A cause transcript-specific DNA methylation patterns and affect hematopoiesis

Tanja Božić, Joana Frobel, Annamarija Raic, Fabio Ticconi, Chao-Chung Kuo, Stefanie Heilmann-Heimbach, Tamme W Goecke, View ORCID ProfileMartin Zenke, Edgar Jost, View ORCID ProfileIvan G Costa, View ORCID ProfileWolfgang Wagner Correspondence email

Tanja Božić

1Helmholtz-Institute for Biomedical Engineering, Stem Cell Biology and Cellular Engineering, RWTH Aachen University Medical School, Aachen, Germany

2Institute for Biomedical Engineering—Cell Biology, RWTH Aachen University Medical School, Aachen, Germany

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Joana Frobel

1Helmholtz-Institute for Biomedical Engineering, Stem Cell Biology and Cellular Engineering, RWTH Aachen University Medical School, Aachen, Germany

2Institute for Biomedical Engineering—Cell Biology, RWTH Aachen University Medical School, Aachen, Germany

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Annamarija Raic

1Helmholtz-Institute for Biomedical Engineering, Stem Cell Biology and Cellular Engineering, RWTH Aachen University Medical School, Aachen, Germany

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Fabio Ticconi

3Institute for Computational Genomics, RWTH Aachen University Medical School, Aachen, Germany

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Chao-Chung Kuo

3Institute for Computational Genomics, RWTH Aachen University Medical School, Aachen, Germany

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Stefanie Heilmann-Heimbach

4Institute of Human Genetics, Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany

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Tamme W Goecke

5Department of Obstetrics and Gynecology, RWTH Aachen University Medical School, Aachen, Germany

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Martin Zenke

1Helmholtz-Institute for Biomedical Engineering, Stem Cell Biology and Cellular Engineering, RWTH Aachen University Medical School, Aachen, Germany

2Institute for Biomedical Engineering—Cell Biology, RWTH Aachen University Medical School, Aachen, Germany

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ORCID record for Martin Zenke

Edgar Jost

6Clinic for Hematology, Oncology, Hemostaseology and Stem Cell Transplantation, RWTH Aachen University Medical School, Aachen, Germany

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Ivan G Costa

3Institute for Computational Genomics, RWTH Aachen University Medical School, Aachen, Germany

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Wolfgang Wagner

1Helmholtz-Institute for Biomedical Engineering, Stem Cell Biology and Cellular Engineering, RWTH Aachen University Medical School, Aachen, Germany

2Institute for Biomedical Engineering—Cell Biology, RWTH Aachen University Medical School, Aachen, Germany

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ORCID record for Wolfgang Wagner
For correspondence: wwagner@ukaachen.de

Published 13 December 2018. DOI: 10.26508/lsa.201800153

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Transcript-specific function of DNMT3A

Tanja Božić, Joana Frobel, Annamarija Raic, Fabio Ticconi, Chao-Chung Kuo, Stefanie Heilmann-Heimbach, Tamme W Goecke, Martin Zenke, Edgar Jost, Ivan G Costa, Wolfgang Wagner

Life Science Alliance Dec 2018, 1 (6) e201800153; DOI: 10.26508/lsa.201800153

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Transcript-specific function of DNMT3A

Tanja Božić, Joana Frobel, Annamarija Raic, Fabio Ticconi, Chao-Chung Kuo, Stefanie Heilmann-Heimbach, Tamme W Goecke, Martin Zenke, Edgar Jost, Ivan G Costa, Wolfgang Wagner

Life Science Alliance Dec 2018, 1 (6) e201800153; DOI: 10.26508/lsa.201800153

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