Research Article
Open Access
Disruption of stromal hedgehog signaling initiates RNF5-mediated proteasomal degradation of PTEN and accelerates pancreatic tumor growth
Jason R Pitarresi, Xin Liu, Alex Avendano, Katie A Thies, Gina M Sizemore, Anisha M Hammer, View ORCID ProfileBlake E Hildreth, David J Wang, Sarah A Steck, Sydney Donohue, Maria C Cuitiño, Raleigh D Kladney, Thomas A Mace, Jonathan J Chang, Christina S Ennis, Huiqing Li, View ORCID ProfileRoger H Reeves, Seth Blackshaw, Jianying Zhang, Lianbo Yu, Soledad A Fernandez, Wendy L Frankel, Mark Bloomston, Thomas J Rosol, Gregory B Lesinski, Stephen F Konieczny, Denis C Guttridge, Anil K Rustgi, Gustavo Leone, View ORCID ProfileJonathan W Song, Jinghai Wu, View ORCID ProfileMichael C Ostrowski Correspondence email
Jason R Pitarresi
2Ohio State Biochemistry Graduate Program, The Ohio State University Columbus, Columbus, OH, USA
16Division of Gastroenterology, Department of Medicine and Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA
Xin Liu
2Ohio State Biochemistry Graduate Program, The Ohio State University Columbus, Columbus, OH, USA
17Department of Surgery, Stanford University, Stanford, CA, USA
Alex Avendano
3Department of Mechanical and Aerospace Engineering and Ohio State Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA
Katie A Thies
1Hollings Cancer Center and Department of Biochemistry & Molecular Biology, Medical University of South Carolina, Charleston, SC, USA
Gina M Sizemore
4Department of Radiation Oncology and Ohio State Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA
Anisha M Hammer
2Ohio State Biochemistry Graduate Program, The Ohio State University Columbus, Columbus, OH, USA
Blake E Hildreth III
1Hollings Cancer Center and Department of Biochemistry & Molecular Biology, Medical University of South Carolina, Charleston, SC, USA
David J Wang
5Hollings Cancer Center and the Darby Children's Research Institute, Medical University of South Carolina, Charleston, SC, USA
Sarah A Steck
4Department of Radiation Oncology and Ohio State Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA
Sydney Donohue
6Cancer Biology & Genetics Department and Ohio State Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA
Maria C Cuitiño
1Hollings Cancer Center and Department of Biochemistry & Molecular Biology, Medical University of South Carolina, Charleston, SC, USA
2Ohio State Biochemistry Graduate Program, The Ohio State University Columbus, Columbus, OH, USA
Raleigh D Kladney
6Cancer Biology & Genetics Department and Ohio State Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA
Thomas A Mace
7Department of Internal Medicine, The Ohio State University, Columbus, OH, USA
Jonathan J Chang
3Department of Mechanical and Aerospace Engineering and Ohio State Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA
Christina S Ennis
3Department of Mechanical and Aerospace Engineering and Ohio State Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA
Huiqing Li
8Department of Physiology and McKusick-Nathans Institute for Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Roger H Reeves
8Department of Physiology and McKusick-Nathans Institute for Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Seth Blackshaw
9Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA
Jianying Zhang
10Department of Biomedical Informatics' and Center for Biostatistics, The Ohio State University, Columbus, OH, USA
Lianbo Yu
10Department of Biomedical Informatics' and Center for Biostatistics, The Ohio State University, Columbus, OH, USA
Soledad A Fernandez
10Department of Biomedical Informatics' and Center for Biostatistics, The Ohio State University, Columbus, OH, USA
Wendy L Frankel
11Department of Pathology, The Ohio State University, Columbus, OH, USA
Mark Bloomston
12Department of Surgery, The Ohio State University, Columbus, OH, USA
Thomas J Rosol
13Department of Biomedical Sciences, Ohio University, Athens, OH, USA
Gregory B Lesinski
14Department of Hematology & Medical Oncology and Winship Cancer Institute, Emory University, Atlanta, GA, USA
Stephen F Konieczny
15Department of Biological Sciences, Purdue Center for Cancer Research and Bindley Bioscience Center, Purdue University, West Lafayette, IN, USA
Denis C Guttridge
2Ohio State Biochemistry Graduate Program, The Ohio State University Columbus, Columbus, OH, USA
5Hollings Cancer Center and the Darby Children's Research Institute, Medical University of South Carolina, Charleston, SC, USA
Anil K Rustgi
16Division of Gastroenterology, Department of Medicine and Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA
Gustavo Leone
1Hollings Cancer Center and Department of Biochemistry & Molecular Biology, Medical University of South Carolina, Charleston, SC, USA
2Ohio State Biochemistry Graduate Program, The Ohio State University Columbus, Columbus, OH, USA
Jonathan W Song
3Department of Mechanical and Aerospace Engineering and Ohio State Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA
Jinghai Wu
6Cancer Biology & Genetics Department and Ohio State Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA
Michael C Ostrowski
1Hollings Cancer Center and Department of Biochemistry & Molecular Biology, Medical University of South Carolina, Charleston, SC, USA
2Ohio State Biochemistry Graduate Program, The Ohio State University Columbus, Columbus, OH, USA
Published 26 October 2018. DOI: 10.26508/lsa.201800190
Stromal PTEN loss enhances PDAC growth
Jason R Pitarresi, Xin Liu, Alex Avendano, Katie A Thies, Gina M Sizemore, Anisha M Hammer, Blake E Hildreth, David J Wang, Sarah A Steck, Sydney Donohue, Maria C Cuitiño, Raleigh D Kladney, Thomas A Mace, Jonathan J Chang, Christina S Ennis, Huiqing Li, Roger H Reeves, Seth Blackshaw, Jianying Zhang, Lianbo Yu, Soledad A Fernandez, Wendy L Frankel, Mark Bloomston, Thomas J Rosol, Gregory B Lesinski, Stephen F Konieczny, Denis C Guttridge, Anil K Rustgi, Gustavo Leone, Jonathan W Song, Jinghai Wu, Michael C Ostrowski
Life Science Alliance Oct 2018, 1 (5) e201800190; DOI: 10.26508/lsa.201800190
Stromal PTEN loss enhances PDAC growth
Jason R Pitarresi, Xin Liu, Alex Avendano, Katie A Thies, Gina M Sizemore, Anisha M Hammer, Blake E Hildreth, David J Wang, Sarah A Steck, Sydney Donohue, Maria C Cuitiño, Raleigh D Kladney, Thomas A Mace, Jonathan J Chang, Christina S Ennis, Huiqing Li, Roger H Reeves, Seth Blackshaw, Jianying Zhang, Lianbo Yu, Soledad A Fernandez, Wendy L Frankel, Mark Bloomston, Thomas J Rosol, Gregory B Lesinski, Stephen F Konieczny, Denis C Guttridge, Anil K Rustgi, Gustavo Leone, Jonathan W Song, Jinghai Wu, Michael C Ostrowski
Life Science Alliance Oct 2018, 1 (5) e201800190; DOI: 10.26508/lsa.201800190
In this Issue
Volume 1, No. 5
October 2018
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