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Disruption of stromal hedgehog signaling initiates RNF5-mediated proteasomal degradation of PTEN and accelerates pancreatic tumor growth

Jason R Pitarresi, Xin Liu, Alex Avendano, Katie A Thies, Gina M Sizemore, Anisha M Hammer, View ORCID ProfileBlake E Hildreth, David J Wang, Sarah A Steck, Sydney Donohue, Maria C Cuitiño, Raleigh D Kladney, Thomas A Mace, Jonathan J Chang, Christina S Ennis, Huiqing Li, View ORCID ProfileRoger H Reeves, Seth Blackshaw, Jianying Zhang, Lianbo Yu, Soledad A Fernandez, Wendy L Frankel, Mark Bloomston, Thomas J Rosol, Gregory B Lesinski, Stephen F Konieczny, Denis C Guttridge, Anil K Rustgi, Gustavo Leone, View ORCID ProfileJonathan W Song, Jinghai Wu, View ORCID ProfileMichael C Ostrowski  Correspondence email
Jason R Pitarresi
2Ohio State Biochemistry Graduate Program, The Ohio State University Columbus, Columbus, OH, USA
16Division of Gastroenterology, Department of Medicine and Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA
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Xin Liu
2Ohio State Biochemistry Graduate Program, The Ohio State University Columbus, Columbus, OH, USA
17Department of Surgery, Stanford University, Stanford, CA, USA
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Alex Avendano
3Department of Mechanical and Aerospace Engineering and Ohio State Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA
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Katie A Thies
1Hollings Cancer Center and Department of Biochemistry & Molecular Biology, Medical University of South Carolina, Charleston, SC, USA
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Gina M Sizemore
4Department of Radiation Oncology and Ohio State Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA
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Anisha M Hammer
2Ohio State Biochemistry Graduate Program, The Ohio State University Columbus, Columbus, OH, USA
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Blake E Hildreth III
1Hollings Cancer Center and Department of Biochemistry & Molecular Biology, Medical University of South Carolina, Charleston, SC, USA
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  • ORCID record for Blake E Hildreth III
David J Wang
5Hollings Cancer Center and the Darby Children's Research Institute, Medical University of South Carolina, Charleston, SC, USA
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Sarah A Steck
4Department of Radiation Oncology and Ohio State Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA
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Sydney Donohue
6Cancer Biology & Genetics Department and Ohio State Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA
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Maria C Cuitiño
1Hollings Cancer Center and Department of Biochemistry & Molecular Biology, Medical University of South Carolina, Charleston, SC, USA
2Ohio State Biochemistry Graduate Program, The Ohio State University Columbus, Columbus, OH, USA
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Raleigh D Kladney
6Cancer Biology & Genetics Department and Ohio State Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA
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Thomas A Mace
7Department of Internal Medicine, The Ohio State University, Columbus, OH, USA
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Jonathan J Chang
3Department of Mechanical and Aerospace Engineering and Ohio State Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA
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Christina S Ennis
3Department of Mechanical and Aerospace Engineering and Ohio State Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA
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Huiqing Li
8Department of Physiology and McKusick-Nathans Institute for Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
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Roger H Reeves
8Department of Physiology and McKusick-Nathans Institute for Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
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  • ORCID record for Roger H Reeves
Seth Blackshaw
9Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA
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Jianying Zhang
10Department of Biomedical Informatics' and Center for Biostatistics, The Ohio State University, Columbus, OH, USA
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Lianbo Yu
10Department of Biomedical Informatics' and Center for Biostatistics, The Ohio State University, Columbus, OH, USA
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Soledad A Fernandez
10Department of Biomedical Informatics' and Center for Biostatistics, The Ohio State University, Columbus, OH, USA
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Wendy L Frankel
11Department of Pathology, The Ohio State University, Columbus, OH, USA
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Mark Bloomston
12Department of Surgery, The Ohio State University, Columbus, OH, USA
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Thomas J Rosol
13Department of Biomedical Sciences, Ohio University, Athens, OH, USA
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Gregory B Lesinski
14Department of Hematology & Medical Oncology and Winship Cancer Institute, Emory University, Atlanta, GA, USA
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Stephen F Konieczny
15Department of Biological Sciences, Purdue Center for Cancer Research and Bindley Bioscience Center, Purdue University, West Lafayette, IN, USA
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Denis C Guttridge
2Ohio State Biochemistry Graduate Program, The Ohio State University Columbus, Columbus, OH, USA
5Hollings Cancer Center and the Darby Children's Research Institute, Medical University of South Carolina, Charleston, SC, USA
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Anil K Rustgi
16Division of Gastroenterology, Department of Medicine and Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA
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Gustavo Leone
1Hollings Cancer Center and Department of Biochemistry & Molecular Biology, Medical University of South Carolina, Charleston, SC, USA
2Ohio State Biochemistry Graduate Program, The Ohio State University Columbus, Columbus, OH, USA
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Jonathan W Song
3Department of Mechanical and Aerospace Engineering and Ohio State Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA
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  • ORCID record for Jonathan W Song
Jinghai Wu
6Cancer Biology & Genetics Department and Ohio State Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA
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Michael C Ostrowski
1Hollings Cancer Center and Department of Biochemistry & Molecular Biology, Medical University of South Carolina, Charleston, SC, USA
2Ohio State Biochemistry Graduate Program, The Ohio State University Columbus, Columbus, OH, USA
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  • ORCID record for Michael C Ostrowski
  • For correspondence: ostrowsk@musc.com
Published 26 October 2018. DOI: 10.26508/lsa.201800190
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Stromal PTEN loss enhances PDAC growth
Jason R Pitarresi, Xin Liu, Alex Avendano, Katie A Thies, Gina M Sizemore, Anisha M Hammer, Blake E Hildreth, David J Wang, Sarah A Steck, Sydney Donohue, Maria C Cuitiño, Raleigh D Kladney, Thomas A Mace, Jonathan J Chang, Christina S Ennis, Huiqing Li, Roger H Reeves, Seth Blackshaw, Jianying Zhang, Lianbo Yu, Soledad A Fernandez, Wendy L Frankel, Mark Bloomston, Thomas J Rosol, Gregory B Lesinski, Stephen F Konieczny, Denis C Guttridge, Anil K Rustgi, Gustavo Leone, Jonathan W Song, Jinghai Wu, Michael C Ostrowski
Life Science Alliance Oct 2018, 1 (5) e201800190; DOI: 10.26508/lsa.201800190

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Stromal PTEN loss enhances PDAC growth
Jason R Pitarresi, Xin Liu, Alex Avendano, Katie A Thies, Gina M Sizemore, Anisha M Hammer, Blake E Hildreth, David J Wang, Sarah A Steck, Sydney Donohue, Maria C Cuitiño, Raleigh D Kladney, Thomas A Mace, Jonathan J Chang, Christina S Ennis, Huiqing Li, Roger H Reeves, Seth Blackshaw, Jianying Zhang, Lianbo Yu, Soledad A Fernandez, Wendy L Frankel, Mark Bloomston, Thomas J Rosol, Gregory B Lesinski, Stephen F Konieczny, Denis C Guttridge, Anil K Rustgi, Gustavo Leone, Jonathan W Song, Jinghai Wu, Michael C Ostrowski
Life Science Alliance Oct 2018, 1 (5) e201800190; DOI: 10.26508/lsa.201800190
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Volume 1, No. 5
October 2018
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