Disruption of stromal hedgehog signaling initiates RNF5-mediated proteasomal degradation of PTEN and accelerates pancreatic tumor growth

Jason R Pitarresi; Xin Liu; Alex Avendano; Katie A Thies; Gina M Sizemore; Anisha M Hammer; Blake E Hildreth; David J Wang; Sarah A Steck; Sydney Donohue; Maria C Cuitiño; Raleigh D Kladney; Thomas A Mace; Jonathan J Chang; Christina S Ennis; Huiqing Li; Roger H Reeves; Seth Blackshaw; Jianying Zhang; Lianbo Yu; Soledad A Fernandez; Wendy L Frankel; Mark Bloomston; Thomas J Rosol; Gregory B Lesinski; Stephen F Konieczny; Denis C Guttridge; Anil K Rustgi; Gustavo Leone; Jonathan W Song; Jinghai Wu; Michael C Ostrowski

doi:10.26508/lsa.201800190

Research Article

Open Access

Disruption of stromal hedgehog signaling initiates RNF5-mediated proteasomal degradation of PTEN and accelerates pancreatic tumor growth

Jason R Pitarresi, Xin Liu, Alex Avendano, Katie A Thies, Gina M Sizemore, Anisha M Hammer, View ORCID ProfileBlake E Hildreth, David J Wang, Sarah A Steck, Sydney Donohue, Maria C Cuitiño, Raleigh D Kladney, Thomas A Mace, Jonathan J Chang, Christina S Ennis, Huiqing Li, View ORCID ProfileRoger H Reeves, Seth Blackshaw, Jianying Zhang, Lianbo Yu, Soledad A Fernandez, Wendy L Frankel, Mark Bloomston, Thomas J Rosol, Gregory B Lesinski, Stephen F Konieczny, Denis C Guttridge, Anil K Rustgi, Gustavo Leone, View ORCID ProfileJonathan W Song, Jinghai Wu, View ORCID ProfileMichael C Ostrowski Correspondence email

Jason R Pitarresi

2Ohio State Biochemistry Graduate Program, The Ohio State University Columbus, Columbus, OH, USA

16Division of Gastroenterology, Department of Medicine and Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA

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Xin Liu

2Ohio State Biochemistry Graduate Program, The Ohio State University Columbus, Columbus, OH, USA

17Department of Surgery, Stanford University, Stanford, CA, USA

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Alex Avendano

3Department of Mechanical and Aerospace Engineering and Ohio State Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA

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Katie A Thies

1Hollings Cancer Center and Department of Biochemistry & Molecular Biology, Medical University of South Carolina, Charleston, SC, USA

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Gina M Sizemore

4Department of Radiation Oncology and Ohio State Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA

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Anisha M Hammer

2Ohio State Biochemistry Graduate Program, The Ohio State University Columbus, Columbus, OH, USA

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Blake E Hildreth III

1Hollings Cancer Center and Department of Biochemistry & Molecular Biology, Medical University of South Carolina, Charleston, SC, USA

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ORCID record for Blake E Hildreth III

David J Wang

5Hollings Cancer Center and the Darby Children's Research Institute, Medical University of South Carolina, Charleston, SC, USA

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Sarah A Steck

4Department of Radiation Oncology and Ohio State Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA

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Sydney Donohue

6Cancer Biology & Genetics Department and Ohio State Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA

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Maria C Cuitiño

1Hollings Cancer Center and Department of Biochemistry & Molecular Biology, Medical University of South Carolina, Charleston, SC, USA

2Ohio State Biochemistry Graduate Program, The Ohio State University Columbus, Columbus, OH, USA

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Raleigh D Kladney

6Cancer Biology & Genetics Department and Ohio State Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA

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Thomas A Mace

7Department of Internal Medicine, The Ohio State University, Columbus, OH, USA

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Jonathan J Chang

3Department of Mechanical and Aerospace Engineering and Ohio State Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA

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Christina S Ennis

3Department of Mechanical and Aerospace Engineering and Ohio State Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA

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Huiqing Li

8Department of Physiology and McKusick-Nathans Institute for Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA

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Roger H Reeves

8Department of Physiology and McKusick-Nathans Institute for Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA

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ORCID record for Roger H Reeves

Seth Blackshaw

9Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA

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Jianying Zhang

10Department of Biomedical Informatics' and Center for Biostatistics, The Ohio State University, Columbus, OH, USA

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Lianbo Yu

10Department of Biomedical Informatics' and Center for Biostatistics, The Ohio State University, Columbus, OH, USA

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Soledad A Fernandez

10Department of Biomedical Informatics' and Center for Biostatistics, The Ohio State University, Columbus, OH, USA

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Wendy L Frankel

11Department of Pathology, The Ohio State University, Columbus, OH, USA

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Mark Bloomston

12Department of Surgery, The Ohio State University, Columbus, OH, USA

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Thomas J Rosol

13Department of Biomedical Sciences, Ohio University, Athens, OH, USA

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Gregory B Lesinski

14Department of Hematology & Medical Oncology and Winship Cancer Institute, Emory University, Atlanta, GA, USA

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Stephen F Konieczny

15Department of Biological Sciences, Purdue Center for Cancer Research and Bindley Bioscience Center, Purdue University, West Lafayette, IN, USA

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Denis C Guttridge

2Ohio State Biochemistry Graduate Program, The Ohio State University Columbus, Columbus, OH, USA

5Hollings Cancer Center and the Darby Children's Research Institute, Medical University of South Carolina, Charleston, SC, USA

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Anil K Rustgi

16Division of Gastroenterology, Department of Medicine and Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA

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Gustavo Leone

1Hollings Cancer Center and Department of Biochemistry & Molecular Biology, Medical University of South Carolina, Charleston, SC, USA

2Ohio State Biochemistry Graduate Program, The Ohio State University Columbus, Columbus, OH, USA

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Jonathan W Song

3Department of Mechanical and Aerospace Engineering and Ohio State Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA

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ORCID record for Jonathan W Song

Jinghai Wu

6Cancer Biology & Genetics Department and Ohio State Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA

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Michael C Ostrowski

1Hollings Cancer Center and Department of Biochemistry & Molecular Biology, Medical University of South Carolina, Charleston, SC, USA

2Ohio State Biochemistry Graduate Program, The Ohio State University Columbus, Columbus, OH, USA

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ORCID record for Michael C Ostrowski
For correspondence: ostrowsk@musc.com

Published 26 October 2018. DOI: 10.26508/lsa.201800190

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Citation Tools

Stromal PTEN loss enhances PDAC growth

Jason R Pitarresi, Xin Liu, Alex Avendano, Katie A Thies, Gina M Sizemore, Anisha M Hammer, Blake E Hildreth, David J Wang, Sarah A Steck, Sydney Donohue, Maria C Cuitiño, Raleigh D Kladney, Thomas A Mace, Jonathan J Chang, Christina S Ennis, Huiqing Li, Roger H Reeves, Seth Blackshaw, Jianying Zhang, Lianbo Yu, Soledad A Fernandez, Wendy L Frankel, Mark Bloomston, Thomas J Rosol, Gregory B Lesinski, Stephen F Konieczny, Denis C Guttridge, Anil K Rustgi, Gustavo Leone, Jonathan W Song, Jinghai Wu, Michael C Ostrowski

Life Science Alliance Oct 2018, 1 (5) e201800190; DOI: 10.26508/lsa.201800190