Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Newest Articles
    • Current Issue
    • Methods & Resources
    • Archive
    • Subjects
  • Collections
  • Submit
    • Submit a Manuscript
    • Author Guidelines
    • License, Copyright, Fee
    • FAQ
    • Why Submit
  • About
    • About Us
    • Editors & Staff
    • Board Members
    • Licensing and Reuse
    • Reviewer Guidelines
    • Privacy Policy
    • Advertise
    • Contact Us
    • LSA LLC
  • Alerts
  • Other Publications
    • EMBO Press
    • The EMBO Journal
    • EMBO reports
    • EMBO Molecular Medicine
    • Molecular Systems Biology
    • Rockefeller University Press
    • Journal of Cell Biology
    • Journal of Experimental Medicine
    • Journal of General Physiology
    • Cold Spring Harbor Laboratory Press
    • Genes & Development
    • Genome Research

User menu

  • My alerts

Search

  • Advanced search
Life Science Alliance
  • Other Publications
    • EMBO Press
    • The EMBO Journal
    • EMBO reports
    • EMBO Molecular Medicine
    • Molecular Systems Biology
    • Rockefeller University Press
    • Journal of Cell Biology
    • Journal of Experimental Medicine
    • Journal of General Physiology
    • Cold Spring Harbor Laboratory Press
    • Genes & Development
    • Genome Research
  • My alerts
Life Science Alliance

Advanced Search

  • Home
  • Articles
    • Newest Articles
    • Current Issue
    • Methods & Resources
    • Archive
    • Subjects
  • Collections
  • Submit
    • Submit a Manuscript
    • Author Guidelines
    • License, Copyright, Fee
    • FAQ
    • Why Submit
  • About
    • About Us
    • Editors & Staff
    • Board Members
    • Licensing and Reuse
    • Reviewer Guidelines
    • Privacy Policy
    • Advertise
    • Contact Us
    • LSA LLC
  • Alerts
  • Follow lsa Template on Twitter
Research Article
Transparent Process
Open Access

Disruption of stromal hedgehog signaling initiates RNF5-mediated proteasomal degradation of PTEN and accelerates pancreatic tumor growth

Jason R Pitarresi, Xin Liu, Alex Avendano, Katie A Thies, Gina M Sizemore, Anisha M Hammer, View ORCID ProfileBlake E Hildreth, David J Wang, Sarah A Steck, Sydney Donohue, Maria C Cuitiño, Raleigh D Kladney, Thomas A Mace, Jonathan J Chang, Christina S Ennis, Huiqing Li, View ORCID ProfileRoger H Reeves, Seth Blackshaw, Jianying Zhang, Lianbo Yu, Soledad A Fernandez, Wendy L Frankel, Mark Bloomston, Thomas J Rosol, Gregory B Lesinski, Stephen F Konieczny, Denis C Guttridge, Anil K Rustgi, Gustavo Leone, View ORCID ProfileJonathan W Song, Jinghai Wu, View ORCID ProfileMichael C Ostrowski  Correspondence email
Jason R Pitarresi
2Ohio State Biochemistry Graduate Program, The Ohio State University Columbus, Columbus, OH, USA
16Division of Gastroenterology, Department of Medicine and Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Xin Liu
2Ohio State Biochemistry Graduate Program, The Ohio State University Columbus, Columbus, OH, USA
17Department of Surgery, Stanford University, Stanford, CA, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Alex Avendano
3Department of Mechanical and Aerospace Engineering and Ohio State Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Katie A Thies
1Hollings Cancer Center and Department of Biochemistry & Molecular Biology, Medical University of South Carolina, Charleston, SC, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Gina M Sizemore
4Department of Radiation Oncology and Ohio State Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Anisha M Hammer
2Ohio State Biochemistry Graduate Program, The Ohio State University Columbus, Columbus, OH, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Blake E Hildreth III
1Hollings Cancer Center and Department of Biochemistry & Molecular Biology, Medical University of South Carolina, Charleston, SC, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Blake E Hildreth III
David J Wang
5Hollings Cancer Center and the Darby Children's Research Institute, Medical University of South Carolina, Charleston, SC, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Sarah A Steck
4Department of Radiation Oncology and Ohio State Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Sydney Donohue
6Cancer Biology & Genetics Department and Ohio State Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Maria C Cuitiño
1Hollings Cancer Center and Department of Biochemistry & Molecular Biology, Medical University of South Carolina, Charleston, SC, USA
2Ohio State Biochemistry Graduate Program, The Ohio State University Columbus, Columbus, OH, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Raleigh D Kladney
6Cancer Biology & Genetics Department and Ohio State Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Thomas A Mace
7Department of Internal Medicine, The Ohio State University, Columbus, OH, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jonathan J Chang
3Department of Mechanical and Aerospace Engineering and Ohio State Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Christina S Ennis
3Department of Mechanical and Aerospace Engineering and Ohio State Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Huiqing Li
8Department of Physiology and McKusick-Nathans Institute for Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Roger H Reeves
8Department of Physiology and McKusick-Nathans Institute for Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Roger H Reeves
Seth Blackshaw
9Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jianying Zhang
10Department of Biomedical Informatics' and Center for Biostatistics, The Ohio State University, Columbus, OH, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Lianbo Yu
10Department of Biomedical Informatics' and Center for Biostatistics, The Ohio State University, Columbus, OH, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Soledad A Fernandez
10Department of Biomedical Informatics' and Center for Biostatistics, The Ohio State University, Columbus, OH, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Wendy L Frankel
11Department of Pathology, The Ohio State University, Columbus, OH, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Mark Bloomston
12Department of Surgery, The Ohio State University, Columbus, OH, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Thomas J Rosol
13Department of Biomedical Sciences, Ohio University, Athens, OH, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Gregory B Lesinski
14Department of Hematology & Medical Oncology and Winship Cancer Institute, Emory University, Atlanta, GA, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Stephen F Konieczny
15Department of Biological Sciences, Purdue Center for Cancer Research and Bindley Bioscience Center, Purdue University, West Lafayette, IN, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Denis C Guttridge
2Ohio State Biochemistry Graduate Program, The Ohio State University Columbus, Columbus, OH, USA
5Hollings Cancer Center and the Darby Children's Research Institute, Medical University of South Carolina, Charleston, SC, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Anil K Rustgi
16Division of Gastroenterology, Department of Medicine and Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Gustavo Leone
1Hollings Cancer Center and Department of Biochemistry & Molecular Biology, Medical University of South Carolina, Charleston, SC, USA
2Ohio State Biochemistry Graduate Program, The Ohio State University Columbus, Columbus, OH, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jonathan W Song
3Department of Mechanical and Aerospace Engineering and Ohio State Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Jonathan W Song
Jinghai Wu
6Cancer Biology & Genetics Department and Ohio State Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Michael C Ostrowski
1Hollings Cancer Center and Department of Biochemistry & Molecular Biology, Medical University of South Carolina, Charleston, SC, USA
2Ohio State Biochemistry Graduate Program, The Ohio State University Columbus, Columbus, OH, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Michael C Ostrowski
  • For correspondence: ostrowsk@musc.com
Published 26 October 2018. DOI: 10.26508/lsa.201800190
  • Article
  • Figures & Data
  • Info
  • Metrics
  • Reviewer Comments
  • PDF
Loading

Article Information

vol. 1 no. 5 e201800190
DOI 
https://doi.org/10.26508/lsa.201800190
PubMed 
30456390

Published By 
Life Science Alliance
Online ISSN 
2575-1077
History 
  • Received September 10, 2018
  • Revision received October 16, 2018
  • Accepted October 17, 2018
  • Published online October 26, 2018.

Copyright & Usage 
© 2018 Pitarresi et al. This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).

Author Information

  1. Jason R Pitarresi2,16,*,
  2. Xin Liu2,17,*,
  3. Alex Avendano3,
  4. Katie A Thies1,
  5. Gina M Sizemore4,
  6. Anisha M Hammer2,
  7. Blake E Hildreth III1,
  8. David J Wang5,
  9. Sarah A Steck4,
  10. Sydney Donohue6,
  11. Maria C Cuitiño1,2,
  12. Raleigh D Kladney6,
  13. Thomas A Mace7,
  14. Jonathan J Chang3,
  15. Christina S Ennis3,
  16. Huiqing Li8,
  17. Roger H Reeves8,
  18. Seth Blackshaw9,
  19. Jianying Zhang10,
  20. Lianbo Yu10,
  21. Soledad A Fernandez10,
  22. Wendy L Frankel11,
  23. Mark Bloomston12,
  24. Thomas J Rosol13,
  25. Gregory B Lesinski14,
  26. Stephen F Konieczny15,
  27. Denis C Guttridge2,5,
  28. Anil K Rustgi16,
  29. Gustavo Leone1,2,
  30. Jonathan W Song3,
  31. Jinghai Wu6 and
  32. Michael C Ostrowski1,2⇑
  1. 1Hollings Cancer Center and Department of Biochemistry & Molecular Biology, Medical University of South Carolina, Charleston, SC, USA
  2. 2Ohio State Biochemistry Graduate Program, The Ohio State University Columbus, Columbus, OH, USA
  3. 3Department of Mechanical and Aerospace Engineering and Ohio State Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA
  4. 4Department of Radiation Oncology and Ohio State Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA
  5. 5Hollings Cancer Center and the Darby Children's Research Institute, Medical University of South Carolina, Charleston, SC, USA
  6. 6Cancer Biology & Genetics Department and Ohio State Comprehensive Cancer Center, The Ohio State University, Columbus, OH, USA
  7. 7Department of Internal Medicine, The Ohio State University, Columbus, OH, USA
  8. 8Department of Physiology and McKusick-Nathans Institute for Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD, USA
  9. 9Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA
  10. 10Department of Biomedical Informatics' and Center for Biostatistics, The Ohio State University, Columbus, OH, USA
  11. 11Department of Pathology, The Ohio State University, Columbus, OH, USA
  12. 12Department of Surgery, The Ohio State University, Columbus, OH, USA
  13. 13Department of Biomedical Sciences, Ohio University, Athens, OH, USA
  14. 14Department of Hematology & Medical Oncology and Winship Cancer Institute, Emory University, Atlanta, GA, USA
  15. 15Department of Biological Sciences, Purdue Center for Cancer Research and Bindley Bioscience Center, Purdue University, West Lafayette, IN, USA
  16. 16Division of Gastroenterology, Department of Medicine and Abramson Cancer Center, University of Pennsylvania, Philadelphia, PA, USA
  17. 17Department of Surgery, Stanford University, Stanford, CA, USA
  1. Correspondence: ostrowsk{at}musc.com
  1. ↵* Jason R Pitarresi and Xin Liu contributed equally to this work.

View Full Text

Funding

  • National Institutes of Health

    PO1 CA097189
    MC Ostrowski, G Leone
  • NRSA F31 CA189757

    JR Pitarresi
  • NRSA F32 CA221094

    JR Pitarresi
  • American Cancer Society IRG-67-003-50

    JW Song
  • American Heart Association

    15SDG25480000
    JW Song
  • R01 CA124586

    SF Konieczny
  • Department of Defense

    W81XWH-14-1-0040
    GM Sizemore
  • OSU Institute for Materials Research

PreviousNext
Back to top
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word on Life Science Alliance.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Disruption of stromal hedgehog signaling initiates RNF5-mediated proteasomal degradation of PTEN and accelerates pancreatic tumor growth
(Your Name) has sent you a message from Life Science Alliance
(Your Name) thought you would like to see the Life Science Alliance web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Stromal PTEN loss enhances PDAC growth
Jason R Pitarresi, Xin Liu, Alex Avendano, Katie A Thies, Gina M Sizemore, Anisha M Hammer, Blake E Hildreth, David J Wang, Sarah A Steck, Sydney Donohue, Maria C Cuitiño, Raleigh D Kladney, Thomas A Mace, Jonathan J Chang, Christina S Ennis, Huiqing Li, Roger H Reeves, Seth Blackshaw, Jianying Zhang, Lianbo Yu, Soledad A Fernandez, Wendy L Frankel, Mark Bloomston, Thomas J Rosol, Gregory B Lesinski, Stephen F Konieczny, Denis C Guttridge, Anil K Rustgi, Gustavo Leone, Jonathan W Song, Jinghai Wu, Michael C Ostrowski
Life Science Alliance Oct 2018, 1 (5) e201800190; DOI: 10.26508/lsa.201800190

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Stromal PTEN loss enhances PDAC growth
Jason R Pitarresi, Xin Liu, Alex Avendano, Katie A Thies, Gina M Sizemore, Anisha M Hammer, Blake E Hildreth, David J Wang, Sarah A Steck, Sydney Donohue, Maria C Cuitiño, Raleigh D Kladney, Thomas A Mace, Jonathan J Chang, Christina S Ennis, Huiqing Li, Roger H Reeves, Seth Blackshaw, Jianying Zhang, Lianbo Yu, Soledad A Fernandez, Wendy L Frankel, Mark Bloomston, Thomas J Rosol, Gregory B Lesinski, Stephen F Konieczny, Denis C Guttridge, Anil K Rustgi, Gustavo Leone, Jonathan W Song, Jinghai Wu, Michael C Ostrowski
Life Science Alliance Oct 2018, 1 (5) e201800190; DOI: 10.26508/lsa.201800190
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
Issue Cover

In this Issue

Volume 1, No. 5
October 2018
  • Table of Contents
  • Cover (PDF)
  • About the Cover
  • Masthead (PDF)
Advertisement

Jump to section

  • Article
    • Abstract
    • Introduction
    • Results
    • Discussion
    • Materials and Methods
    • Acknowledgments
    • References
  • Figures & Data
  • Info
  • Metrics
  • Reviewer Comments
  • PDF

Subjects

  • Cancer

Related Articles

  • No related articles found.

Cited By...

  • Integrated biophysical characterization of fibrillar collagen-based hydrogels
  • PTEN in the Stroma
  • Google Scholar

More in this TOC Section

  • p14ARF and MDM2 AD inhibit RING activity
  • RECODE for scRNA-seq data
  • Pldo/ZSWIM8 and actin polymerization
Show more Research Article

Similar Articles

EMBO Press LogoRockefeller University Press LogoCold Spring Harbor Logo

Content

  • Home
  • Newest Articles
  • Current Issue
  • Archive
  • Subject Collections

For Authors

  • Submit a Manuscript
  • Author Guidelines
  • License, copyright, Fee

Other Services

  • Alerts
  • Twitter
  • RSS Feeds

More Information

  • Editors & Staff
  • Reviewer Guidelines
  • Feedback
  • Licensing and Reuse
  • Privacy Policy

ISSN: 2575-1077
© 2022 Life Science Alliance LLC

Life Science Alliance is registered as a trademark in the U.S. Patent and Trade Mark Office and in the European Union Intellectual Property Office.