Mitochondrial ubiquinone–mediated longevity is marked by reduced cytoplasmic mRNA translation

Marte Molenaars; Georges E Janssens; Toon Santermans; Marco Lezzerini; Rob Jelier; Alyson W MacInnes; Riekelt H Houtkooper

doi:10.26508/lsa.201800082

Research Article

Open Access

Mitochondrial ubiquinone–mediated longevity is marked by reduced cytoplasmic mRNA translation

Marte Molenaars, Georges E Janssens, Toon Santermans, Marco Lezzerini, Rob Jelier, Alyson W MacInnes Correspondence email, View ORCID ProfileRiekelt H Houtkooper Correspondence email

Marte Molenaars

1Laboratory Genetic Metabolic Diseases, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam Gastroenterology and Metabolism, Amsterdam, The Netherlands

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Georges E Janssens

1Laboratory Genetic Metabolic Diseases, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam Gastroenterology and Metabolism, Amsterdam, The Netherlands

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Toon Santermans

2Centre of Microbial and Plant Genetics University of Leuven, Leuven, Belgium

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Marco Lezzerini

1Laboratory Genetic Metabolic Diseases, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam Gastroenterology and Metabolism, Amsterdam, The Netherlands

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Rob Jelier

2Centre of Microbial and Plant Genetics University of Leuven, Leuven, Belgium

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Alyson W MacInnes

1Laboratory Genetic Metabolic Diseases, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam Gastroenterology and Metabolism, Amsterdam, The Netherlands

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For correspondence: a.w.macinnes@amc.nl

Riekelt H Houtkooper

1Laboratory Genetic Metabolic Diseases, Amsterdam University Medical Centers, University of Amsterdam, Amsterdam Gastroenterology and Metabolism, Amsterdam, The Netherlands

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ORCID record for Riekelt H Houtkooper
For correspondence: r.h.houtkooper@amc.nl

Published 31 August 2018. DOI: 10.26508/lsa.201800082

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Clk-1–dependent ubiquinone biosynthesis affects translation