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Table of Contents

October 2018 | Volume 1, No. 5

Research Articles

  • Dynamic reorganisation of intermediate filaments coordinates early B-cell activation
    Open Access
    Dynamic reorganisation of intermediate filaments coordinates early B-cell activation

    Carlson Tsui, Paula Maldonado, Beatriz Montaner, Aldo Borroto, Balbino Alarcon, Andreas Bruckbauer, Nuria Martinez-Martin, Facundo D Batista

    Carlson Tsui ... Facundo D Batista

    Published 20 August 2018

    This study examines the role of vimentin, a type III intermediate filament, in B-cell function using a combination of in vitro and in vivo assays, including super-resolution microscopic techniques.

  • Mitochondrial ubiquinone–mediated longevity is marked by reduced cytoplasmic mRNA translation
    Open Access
    Mitochondrial ubiquinone–mediated longevity is marked by reduced cytoplasmic mRNA translation

    Marte Molenaars, Georges E Janssens, Toon Santermans, Marco Lezzerini, Rob Jelier, Alyson W MacInnes, Riekelt H Houtkooper

    Marte Molenaars ... Riekelt H Houtkooper

    Published 31 August 2018

    This study uses polysomal RNA sequencing to show that the translational efficiency of specific mRNA changes in long-lived Caenorhabditis elegans with reduced ubiquinone synthesis.

  • MBNL1 alternative splicing isoforms play opposing roles in cancer
    Open Access
    MBNL1 alternative splicing isoforms play opposing roles in cancer

    Tommaso Tabaglio, Diana HP Low, Winnie Koon Lay Teo, Pierre Alexis Goy, Piotr Cywoniuk, Heike Wollmann, Jessica Ho, Damien Tan, Joey Aw, Andrea Pavesi, Krzysztof Sobczak, Dave Keng Boon Wee, Ernesto Guccione

    Tommaso Tabaglio ... Ernesto Guccione

    Published 7 September 2018

    MBNL1 proteins lacking exon 7 (−ex7) are antisurvival factors with tumor suppressive role that cancer cells tend to down-regulate in favor of MBNL +ex7 isoforms.

  • Laminin γ1 C-terminal Glu to Gln mutation induces early postimplantation lethality
    Open Access
    Laminin γ1 C-terminal Glu to Gln mutation induces early postimplantation lethality

    Daiji Kiyozumi, Yukimasa Taniguchi, Itsuko Nakano, Junko Toga, Emiko Yagi, Hidetoshi Hasuwa, Masahito Ikawa, Kiyotoshi Sekiguchi

    Daiji Kiyozumi ... Kiyotoshi Sekiguchi

    Published 10 September 2018

    Mouse embryos with an ablated ability of integrins to bind laminins are still able to form basement membranes, but die just after implantation because of deficient extraembryonic development.

  • Transposon silencing in the <em>Drosophila</em> female germline is essential for genome stability in progeny embryos
    Open Access
    Transposon silencing in the Drosophila female germline is essential for genome stability in progeny embryos

    Zeljko Durdevic, Ramesh S Pillai, Anne Ephrussi

    Zeljko Durdevic ... Anne Ephrussi

    Published 17 September 2018

    Suppression of transposons by the Piwi-interacting RNA biogenesis factor Vasa in the supporting nurse cells is essential to prevent their accumulation in the developing oocyte, ensuring proper Drosophila embryonic development.

  • Identification of <em>Plasmodium</em> GAPDH epitopes for generation of antibodies that inhibit malaria infection
    Open Access
    Identification of Plasmodium GAPDH epitopes for generation of antibodies that inhibit malaria infection

    Sung-Jae Cha, Kyle Jarrod McLean, Marcelo Jacobs-Lorena

    Sung-Jae Cha ... Marcelo Jacobs-Lorena

    Published 18 September 2018

    This study reports on the identification of two Plasmodium GAPDH epitope peptides that are responsible for sporozoite–Kupffer cell interaction and act as antigens against malaria infection.

  • CARM1 methylates MED12 to regulate its RNA-binding ability
    Open Access
    CARM1 methylates MED12 to regulate its RNA-binding ability

    Donghang Cheng, Vidyasiri Vemulapalli, Yue Lu, Jianjun Shen, Sayura Aoyagi, Christopher J Fry, Yanzhong Yang, Charles E Foulds, Fabio Stossi, Lindsey S Treviño, Michael A Mancini, Bert W O'Malley, Cheryl L Walker, Thomas G Boyer, Mark T Bedford

    Donghang Cheng ... Mark T Bedford

    Published 19 September 2018

    CARM1 methylates MED12 at arginine 1899 to generate a TDRD3 binding site, which in turn regulates the ability of mediator to interact with activating ncRNAs and modulate gene expression.

  • S-phase transcriptional buffering quantified on two different promoters
    Open Access
    S-phase transcriptional buffering quantified on two different promoters

    Sharon Yunger, Pinhas Kafri, Liat Rosenfeld, Eliraz Greenberg, Noa Kinor, Yuval Garini, Yaron Shav-Tal

    Sharon Yunger ... Yaron Shav-Tal

    Published 19 September 2018

    Transcriptional buffering enforced during DNA replication shows that histone acetylation governs the homeostasis process and can also restrict promoters from reaching maximum transcriptional potential

  • Interaction modulation through arrays of clustered methyl-arginine protein modifications
    Open Access
    Interaction modulation through arrays of clustered methyl-arginine protein modifications

    Jonathan Woodsmith, Victoria Casado-Medrano, Nouhad Benlasfer, Rebecca L Eccles, Saskia Hutten, Christian L Heine, Verena Thormann, Claudia Abou-Ajram, Oliver Rocks, Dorothee Dormann, Ulrich Stelzl

    Jonathan Woodsmith ... Ulrich Stelzl

    Published 21 September 2018

    Extensively modifiable arrays of clustered arginines in a large set of human proteins function as regulatory protein interaction platforms. Quantitative immunoprecipitation assays defined two distinct cumulative binding mechanisms operating across an array of 18 methyl-arginine motifs in SYNCRIP.

  • Loss of HDAC11 ameliorates clinical symptoms in a multiple sclerosis mouse model
    Open Access
    Loss of HDAC11 ameliorates clinical symptoms in a multiple sclerosis mouse model

    Lei Sun, Elphine Telles, Molly Karl, Fengdong Cheng, Noreen Luetteke, Eduardo M Sotomayor, Robert H Miller, Edward Seto

    Lei Sun ... Edward Seto

    Published 24 September 2018

    In an animal model for multiple sclerosis, the absence of HDAC11 reduces clinical severity, spinal cord demyelination, and immune cell infiltration, suggesting that HDAC11 is a promising target for MS treatment.

  • Secretory granule protein chromogranin B (CHGB) forms an anion channel in membranes
    Open Access
    Secretory granule protein chromogranin B (CHGB) forms an anion channel in membranes

    Gaya P Yadav, Hui Zheng, Qing Yang, Lauren G Douma, Linda B Bloom, Qiu-Xing Jiang

    Gaya P Yadav ... Qiu-Xing Jiang

    Published 24 September 2018

    The CHGB subfamily of secretory granule proteins forms a new family of anion-selective channels by interacting with membranes via two amphipathic α-helices. The channel exhibits higher anion selectivity, larger conductance, higher DIDS-binding affinity, and higher Cl− sensitivity than other known anion channels.

  • Specificity for deubiquitination of monoubiquitinated FANCD2 is driven by the N-terminus of USP1
    Open Access
    Specificity for deubiquitination of monoubiquitinated FANCD2 is driven by the N-terminus of USP1

    Connor Arkinson, Viduth K Chaugule, Rachel Toth, Helen Walden

    Connor Arkinson ... Helen Walden

    Published 12 October 2018

    Deubiquitination of FANCD2, FANCI, and PCNA by USP1 is essential for DNA repair signalling. Reconstitution of the system reveals that USP1-mediated specificity towards K561 of FANCD2 is directed by a unique sequence at USP1's N-terminus.

  • The crystal structure of Staufen1 in complex with a physiological RNA sheds light on substrate selectivity
    Open Access
    The crystal structure of Staufen1 in complex with a physiological RNA sheds light on substrate selectivity

    Daniela Lazzaretti, Lina Bandholz-Cajamarca, Christiane Emmerich, Kristina Schaaf, Claire Basquin, Uwe Irion, Fulvia Bono

    Daniela Lazzaretti ... Fulvia Bono

    Published 18 October 2018

    Combination of in vitro and in vivo data show that RNA sequence influences Staufen target recognition and that protein–RNA base contacts are required for Staufen function in Drosophila.

  • Topological in vitro loading of the budding yeast cohesin ring onto DNA
    Open Access
    Topological in vitro loading of the budding yeast cohesin ring onto DNA

    Masashi Minamino, Torahiko L Higashi, Céline Bouchoux, Frank Uhlmann

    Masashi Minamino ... Frank Uhlmann

    Published 26 October 2018

    The biochemical reconstitution of topological DNA binding by budding yeast cohesin yields surprises and opens opportunities to exploit experimental approaches developed in this model organism.

  • Disruption of stromal hedgehog signaling initiates RNF5-mediated proteasomal degradation of PTEN and accelerates pancreatic tumor growth
    Open Access
    Disruption of stromal hedgehog signaling initiates RNF5-mediated proteasomal degradation of PTEN and accelerates pancreatic tumor growth

    Jason R Pitarresi, Xin Liu, Alex Avendano, Katie A Thies, Gina M Sizemore, Anisha M Hammer, Blake E Hildreth, David J Wang, Sarah A Steck, Sydney Donohue, Maria C Cuitiño, Raleigh D Kladney, Thomas A Mace, Jonathan J Chang, Christina S Ennis, Huiqing Li, Roger H Reeves, Seth Blackshaw, Jianying Zhang, Lianbo Yu, Soledad A Fernandez, Wendy L Frankel, Mark Bloomston, Thomas J Rosol, Gregory B Lesinski, Stephen F Konieczny, Denis C Guttridge, Anil K Rustgi, Gustavo Leone, Jonathan W Song, Jinghai Wu, Michael C Ostrowski

    Jason R Pitarresi ... Michael C Ostrowski

    Published 26 October 2018

    Disrupting paracrine Hedgehog signaling in pancreatic cancer stroma through genetic deletion of fibroblast Smoothened leads to proteasomal degradation of fibroblast PTEN and accelerates tumor growth.

  • Phosphorylation of Arp2 is not essential for Arp2/3 complex activity in fission yeast
    Open Access
    Phosphorylation of Arp2 is not essential for Arp2/3 complex activity in fission yeast

    Alexander E Epstein, Sofia Espinoza-Sanchez, Thomas D Pollard

    Alexander E Epstein ... Thomas D Pollard

    Published 29 October 2018

    This work employed genomic substitutions blocking or mimicking phosphorylation at three proposed phosphorylation sites on Arp2 to demonstrate that they do not regulate Arp2/3 complex activity in fission yeast.

  • LATS1 and LATS2 suppress breast cancer progression by maintaining cell identity and metabolic state
    Open Access
    LATS1 and LATS2 suppress breast cancer progression by maintaining cell identity and metabolic state

    Noa Furth, Ioannis S Pateras, Ron Rotkopf, Vassiliki Vlachou, Irina Rivkin, Ina Schmitt, Deborah Bakaev, Anat Gershoni, Elena Ainbinder, Dena Leshkowitz, Randy L Johnson, Vassilis G Gorgoulis, Moshe Oren, Yael Aylon

    Noa Furth ... Yael Aylon

    Published 30 October 2018

    In luminal B tumors LATS2 depletion results in metabolic rewiring whereas LATS1 depletion promotes the expression of basal-like features.

Methods

  • Ribosomal stalling landscapes revealed by high-throughput inverse toeprinting of mRNA libraries
    Open Access
    Ribosomal stalling landscapes revealed by high-throughput inverse toeprinting of mRNA libraries

    Britta Seip, Guénaël Sacheau, Denis Dupuy, C Axel Innis

    Britta Seip ... C Axel Innis

    Published 9 October 2018

    High-throughput inverse toeprinting identifies peptide-encoding transcripts that induce ribosome stalling and allows the systematic analysis of sequence-dependent translational events.

Resource

  • Small RNA-Seq reveals novel miRNAs shaping the transcriptomic identity of rat brain structures
    Open Access
    Small RNA-Seq reveals novel miRNAs shaping the transcriptomic identity of rat brain structures

    Anaïs Soula, Mélissa Valere, María-José López-González, Vicky Ury-Thiery, Alexis Groppi, Marc Landry, Macha Nikolski, Alexandre Favereaux

    Anaïs Soula ... Alexandre Favereaux

    Published 30 October 2018

    Small RNA-Seq of the rat central nervous system reveals known and novel miRNAs specifically regulated in brain structures and correlated with the expression of their predicted target genes, suggesting a critical role in the transcriptomic identity of brain structures.

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Volume 1, No. 5
October 2018
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