Discovery of a cofactor-independent inhibitor of Mycobacterium tuberculosis InhA

Yi Xia; Yasheen Zhou; David S Carter; Matthew B McNeil; Wai Choi; Jason Halladay; Pamela W Berry; Weimin Mao; Vincent Hernandez; Theresa O'Malley; Aaron Korkegian; Bjorn Sunde; Lindsay Flint; Lisa K Woolhiser; Michael S Scherman; Veronica Gruppo; Courtney Hastings; Gregory T Robertson; Thomas R Ioerger; Jim Sacchettini; Peter J Tonge; Anne J Lenaerts; Tanya Parish; MRK Alley

doi:10.26508/lsa.201800025

Research Article

Open Access

Discovery of a cofactor-independent inhibitor of Mycobacterium tuberculosis InhA

Yi Xia, Yasheen Zhou, David S Carter, Matthew B McNeil, Wai Choi, Jason Halladay, Pamela W Berry, Weimin Mao, Vincent Hernandez, Theresa O'Malley, Aaron Korkegian, Bjorn Sunde, Lindsay Flint, Lisa K Woolhiser, Michael S Scherman, Veronica Gruppo, Courtney Hastings, Gregory T Robertson, Thomas R Ioerger, Jim Sacchettini, Peter J Tonge, Anne J Lenaerts, View ORCID ProfileTanya Parish Correspondence email, MRK Alley

Yi Xia

1Anacor Pharmaceuticals, Palo Alto, CA, USA

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Yasheen Zhou

1Anacor Pharmaceuticals, Palo Alto, CA, USA

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David S Carter

1Anacor Pharmaceuticals, Palo Alto, CA, USA

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Matthew B McNeil

2TB Discovery Research, Infectious Disease Research Institute, Seattle, WA, USA

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Wai Choi

1Anacor Pharmaceuticals, Palo Alto, CA, USA

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Jason Halladay

1Anacor Pharmaceuticals, Palo Alto, CA, USA

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Pamela W Berry

1Anacor Pharmaceuticals, Palo Alto, CA, USA

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Weimin Mao

1Anacor Pharmaceuticals, Palo Alto, CA, USA

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Vincent Hernandez

1Anacor Pharmaceuticals, Palo Alto, CA, USA

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Theresa O'Malley

2TB Discovery Research, Infectious Disease Research Institute, Seattle, WA, USA

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Aaron Korkegian

2TB Discovery Research, Infectious Disease Research Institute, Seattle, WA, USA

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Bjorn Sunde

2TB Discovery Research, Infectious Disease Research Institute, Seattle, WA, USA

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Lindsay Flint

2TB Discovery Research, Infectious Disease Research Institute, Seattle, WA, USA

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Lisa K Woolhiser

3Mycobacteria Research Laboratories, Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO, USA

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Michael S Scherman

3Mycobacteria Research Laboratories, Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO, USA

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Veronica Gruppo

3Mycobacteria Research Laboratories, Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO, USA

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Courtney Hastings

3Mycobacteria Research Laboratories, Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO, USA

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Gregory T Robertson

3Mycobacteria Research Laboratories, Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO, USA

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Thomas R Ioerger

4Texas A&M University, College Station, TX, USA

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Jim Sacchettini

4Texas A&M University, College Station, TX, USA

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Peter J Tonge

5Institute of Chemical Biology and Drug Discovery, Departments of Chemistry and Radiology, Stony Brook University, Stony Brook, NY, USA

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Anne J Lenaerts

3Mycobacteria Research Laboratories, Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO, USA

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Tanya Parish

2TB Discovery Research, Infectious Disease Research Institute, Seattle, WA, USA

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ORCID record for Tanya Parish
For correspondence: tanya.parish@idri.org

MRK Alley

1Anacor Pharmaceuticals, Palo Alto, CA, USA

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Published 1 June 2018. DOI: 10.26508/lsa.201800025

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Direct inhibition of Mycobacterium tuberculosis InhA