Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Newest Articles
    • Current Issue
    • Archive
    • Subjects
  • Submit
    • Submit a Manuscript
    • Author Guidelines
    • License, Copyright, Fee
    • FAQ
    • Why Submit
  • About
    • About Us
    • Editors & Staff
    • Board Members
    • Licensing and Reuse
    • Reviewer Guidelines
    • Privacy Policy
    • Advertise
    • Contact Us
    • LSA LLC
  • Alerts
  • Other Publications
    • EMBO Press
    • The EMBO Journal
    • EMBO reports
    • EMBO Molecular Medicine
    • Molecular Systems Biology
    • Rockefeller University Press
    • Journal of Cell Biology
    • Journal of Experimental Medicine
    • Journal of General Physiology
    • Cold Spring Harbor Laboratory Press
    • Genes & Development
    • Genome Research

User menu

  • My alerts

Search

  • Advanced search
Life Science Alliance
  • Other Publications
    • EMBO Press
    • The EMBO Journal
    • EMBO reports
    • EMBO Molecular Medicine
    • Molecular Systems Biology
    • Rockefeller University Press
    • Journal of Cell Biology
    • Journal of Experimental Medicine
    • Journal of General Physiology
    • Cold Spring Harbor Laboratory Press
    • Genes & Development
    • Genome Research
  • My alerts
Life Science Alliance

Advanced Search

  • Home
  • Articles
    • Newest Articles
    • Current Issue
    • Archive
    • Subjects
  • Submit
    • Submit a Manuscript
    • Author Guidelines
    • License, Copyright, Fee
    • FAQ
    • Why Submit
  • About
    • About Us
    • Editors & Staff
    • Board Members
    • Licensing and Reuse
    • Reviewer Guidelines
    • Privacy Policy
    • Advertise
    • Contact Us
    • LSA LLC
  • Alerts
  • Follow lsa Template on Twitter
Research Article
Transparent Process
Open Access

Discovery of a cofactor-independent inhibitor of Mycobacterium tuberculosis InhA

Yi Xia, Yasheen Zhou, David S Carter, Matthew B McNeil, Wai Choi, Jason Halladay, Pamela W Berry, Weimin Mao, Vincent Hernandez, Theresa O'Malley, Aaron Korkegian, Bjorn Sunde, Lindsay Flint, Lisa K Woolhiser, Michael S Scherman, Veronica Gruppo, Courtney Hastings, Gregory T Robertson, Thomas R Ioerger, Jim Sacchettini, Peter J Tonge, Anne J Lenaerts, View ORCID ProfileTanya Parish  Correspondence email, MRK Alley
Yi Xia
1Anacor Pharmaceuticals, Palo Alto, CA, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Yasheen Zhou
1Anacor Pharmaceuticals, Palo Alto, CA, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
David S Carter
1Anacor Pharmaceuticals, Palo Alto, CA, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Matthew B McNeil
2TB Discovery Research, Infectious Disease Research Institute, Seattle, WA, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Wai Choi
1Anacor Pharmaceuticals, Palo Alto, CA, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jason Halladay
1Anacor Pharmaceuticals, Palo Alto, CA, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Pamela W Berry
1Anacor Pharmaceuticals, Palo Alto, CA, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Weimin Mao
1Anacor Pharmaceuticals, Palo Alto, CA, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Vincent Hernandez
1Anacor Pharmaceuticals, Palo Alto, CA, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Theresa O'Malley
2TB Discovery Research, Infectious Disease Research Institute, Seattle, WA, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Aaron Korkegian
2TB Discovery Research, Infectious Disease Research Institute, Seattle, WA, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Bjorn Sunde
2TB Discovery Research, Infectious Disease Research Institute, Seattle, WA, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Lindsay Flint
2TB Discovery Research, Infectious Disease Research Institute, Seattle, WA, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Lisa K Woolhiser
3Mycobacteria Research Laboratories, Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Michael S Scherman
3Mycobacteria Research Laboratories, Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Veronica Gruppo
3Mycobacteria Research Laboratories, Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Courtney Hastings
3Mycobacteria Research Laboratories, Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Gregory T Robertson
3Mycobacteria Research Laboratories, Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Thomas R Ioerger
4Texas A&M University, College Station, TX, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Jim Sacchettini
4Texas A&M University, College Station, TX, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Peter J Tonge
5Institute of Chemical Biology and Drug Discovery, Departments of Chemistry and Radiology, Stony Brook University, Stony Brook, NY, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Anne J Lenaerts
3Mycobacteria Research Laboratories, Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Tanya Parish
2TB Discovery Research, Infectious Disease Research Institute, Seattle, WA, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • ORCID record for Tanya Parish
  • For correspondence: tanya.parish@idri.org
MRK Alley
1Anacor Pharmaceuticals, Palo Alto, CA, USA
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Published 1 June 2018. DOI: 10.26508/lsa.201800025
  • Article
  • Figures & Data
  • Info
  • Metrics
  • Reviewer Comments
  • PDF
Loading

Article Information

vol. 1 no. 3 e201800025
DOI 
https://doi.org/10.26508/lsa.201800025
PubMed 
30456352

Published By 
Life Science Alliance
Online ISSN 
2575-1077
History 
  • Received January 25, 2018
  • Revision received May 18, 2018
  • Accepted May 22, 2018
  • Published online June 1, 2018.

Copyright & Usage 
© 2018 Xia et al. This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).

Author Information

  1. Yi Xia1,
  2. Yasheen Zhou1,
  3. David S Carter1,
  4. Matthew B McNeil2,
  5. Wai Choi1,
  6. Jason Halladay1,
  7. Pamela W Berry1,
  8. Weimin Mao1,
  9. Vincent Hernandez1,
  10. Theresa O'Malley2,
  11. Aaron Korkegian2,
  12. Bjorn Sunde2,
  13. Lindsay Flint2,
  14. Lisa K Woolhiser3,
  15. Michael S Scherman3,
  16. Veronica Gruppo3,
  17. Courtney Hastings3,
  18. Gregory T Robertson3,
  19. Thomas R Ioerger4,
  20. Jim Sacchettini4,
  21. Peter J Tonge5,
  22. Anne J Lenaerts3,
  23. Tanya Parish2⇑ and
  24. MRK Alley1
  1. 1Anacor Pharmaceuticals, Palo Alto, CA, USA
  2. 2TB Discovery Research, Infectious Disease Research Institute, Seattle, WA, USA
  3. 3Mycobacteria Research Laboratories, Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO, USA
  4. 4Texas A&M University, College Station, TX, USA
  5. 5Institute of Chemical Biology and Drug Discovery, Departments of Chemistry and Radiology, Stony Brook University, Stony Brook, NY, USA
  1. Correspondence: tanya.parish{at}idri.org
View Full Text

Funding

  • Bill & Melinda Gates Foundation

  • NIH

    GM102864
    PJ Tonge
PreviousNext
Back to top
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for your interest in spreading the word on Life Science Alliance.

NOTE: We only request your email address so that the person you are recommending the page to knows that you wanted them to see it, and that it is not junk mail. We do not capture any email address.

Enter multiple addresses on separate lines or separate them with commas.
Discovery of a cofactor-independent inhibitor of Mycobacterium tuberculosis InhA
(Your Name) has sent you a message from Life Science Alliance
(Your Name) thought you would like to see the Life Science Alliance web site.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Direct inhibition of Mycobacterium tuberculosis InhA
Yi Xia, Yasheen Zhou, David S Carter, Matthew B McNeil, Wai Choi, Jason Halladay, Pamela W Berry, Weimin Mao, Vincent Hernandez, Theresa O'Malley, Aaron Korkegian, Bjorn Sunde, Lindsay Flint, Lisa K Woolhiser, Michael S Scherman, Veronica Gruppo, Courtney Hastings, Gregory T Robertson, Thomas R Ioerger, Jim Sacchettini, Peter J Tonge, Anne J Lenaerts, Tanya Parish, MRK Alley
Life Science Alliance Jun 2018, 1 (3) e201800025; DOI: 10.26508/lsa.201800025

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero
Share
Direct inhibition of Mycobacterium tuberculosis InhA
Yi Xia, Yasheen Zhou, David S Carter, Matthew B McNeil, Wai Choi, Jason Halladay, Pamela W Berry, Weimin Mao, Vincent Hernandez, Theresa O'Malley, Aaron Korkegian, Bjorn Sunde, Lindsay Flint, Lisa K Woolhiser, Michael S Scherman, Veronica Gruppo, Courtney Hastings, Gregory T Robertson, Thomas R Ioerger, Jim Sacchettini, Peter J Tonge, Anne J Lenaerts, Tanya Parish, MRK Alley
Life Science Alliance Jun 2018, 1 (3) e201800025; DOI: 10.26508/lsa.201800025
del.icio.us logo Digg logo Reddit logo Twitter logo CiteULike logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
Issue Cover

In this Issue

Volume 1, No. 3
June 2018
  • Table of Contents
  • Cover (PDF)
  • About the Cover
Advertisement

Jump to section

  • Article
    • Abstract
    • Introduction
    • Results
    • Discussion
    • Materials and Methods
    • Supplementary Information
    • Acknowledgements
    • References
  • Figures & Data
  • Info
  • Metrics
  • Reviewer Comments
  • PDF

Subjects

  • Microbiology, Virology & Host Pathogen Interaction
  • Medical Research

EMBO Press LogoRockefeller University Press LogoCold Spring Harbor Logo

Content

  • Home
  • Newest Articles
  • Current Issue
  • Archive
  • Subject Collections

For Authors

  • Submit a Manuscript
  • Author Guidelines
  • License, copyright, Fee

Other Services

  • Alerts
  • Twitter
  • RSS Feeds

More Information

  • Editors & Staff
  • Reviewer Guidelines
  • Feedback
  • Licensing and Reuse
  • Privacy Policy

ISSN: 2575-1077
© 2021 Life Science Alliance LLC

Life Science Alliance is registered as a trademark in the U.S. Patent and Trade Mark Office and in the European Union Intellectual Property Office.