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Proteomics and C9orf72 neuropathology identify ribosomes as poly-GR/PR interactors driving toxicity

Hannelore Hartmann, View ORCID ProfileDaniel Hornburg, Mareike Czuppa, View ORCID ProfileJakob Bader, Meike Michaelsen, Daniel Farny, Thomas Arzberger, Matthias Mann, Felix Meissner, View ORCID ProfileDieter Edbauer  Correspondence email
Hannelore Hartmann
1German Center for Neurodegenerative Diseases (DZNE), Munich, Germany
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Daniel Hornburg
2Max Planck Institute for Biochemistry, Martinsried, Germany
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  • ORCID record for Daniel Hornburg
Mareike Czuppa
1German Center for Neurodegenerative Diseases (DZNE), Munich, Germany
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Jakob Bader
2Max Planck Institute for Biochemistry, Martinsried, Germany
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Meike Michaelsen
1German Center for Neurodegenerative Diseases (DZNE), Munich, Germany
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Daniel Farny
1German Center for Neurodegenerative Diseases (DZNE), Munich, Germany
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Thomas Arzberger
1German Center for Neurodegenerative Diseases (DZNE), Munich, Germany
3Center for Neuropathology and Prion Research, Ludwig-Maximilians-University Munich, Munich, Germany
4Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University Munich, Munich, Germany
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Matthias Mann
2Max Planck Institute for Biochemistry, Martinsried, Germany
4Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University Munich, Munich, Germany
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Felix Meissner
2Max Planck Institute for Biochemistry, Martinsried, Germany
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Dieter Edbauer
1German Center for Neurodegenerative Diseases (DZNE), Munich, Germany
5Ludwig-Maximilians-University Munich, Munich, Germany
6Munich Cluster of Systems Neurology (SyNergy), Munich, Germany
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  • For correspondence: dieter.edbauer@dzne.de
Published 16 May 2018. DOI: 10.26508/lsa.201800070
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Article Information

vol. 1 no. 2 e201800070
DOI 
https://doi.org/10.26508/lsa.201800070
PubMed 
30456350

Published By 
Life Science Alliance
Online ISSN 
2575-1077
History 
  • Received April 20, 2018
  • Revision received April 27, 2018
  • Accepted April 28, 2018
  • Published online May 16, 2018.

Copyright & Usage 
© 2018 Hartmann et al. This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).

Author Information

  1. Hannelore Hartmann1,*,
  2. Daniel Hornburg2,*,
  3. Mareike Czuppa1,
  4. Jakob Bader2,
  5. Meike Michaelsen1,
  6. Daniel Farny1,
  7. Thomas Arzberger1,3,4,
  8. Matthias Mann2,4,
  9. Felix Meissner2 and
  10. Dieter Edbauer1,5,6⇑
  1. 1German Center for Neurodegenerative Diseases (DZNE), Munich, Germany
  2. 2Max Planck Institute for Biochemistry, Martinsried, Germany
  3. 3Center for Neuropathology and Prion Research, Ludwig-Maximilians-University Munich, Munich, Germany
  4. 4Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University Munich, Munich, Germany
  5. 5Ludwig-Maximilians-University Munich, Munich, Germany
  6. 6Munich Cluster of Systems Neurology (SyNergy), Munich, Germany
  1. Correspondence: dieter.edbauer{at}dzne.de
  1. ↵* Hannelore Hartmann and Daniel Hornburg contributed equally to this work.

  • Daniel Hornburg’s present address is Stanford University, School of Medicine, Palo Alto, CA, USA.

View Full Text

Funding

  • Hans und Ilse Breuer Foundation, Munich Cluster of Systems Neurology, NOMIS Foundation

  • European Community’s Health Seventh Framework Programme

    SyG-318987; 259867; 617198
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Proteomics and C9orf72 neuropathology identify ribosomes as poly-GR/PR interactors driving toxicity
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Poly-GR/PR interactome
Hannelore Hartmann, Daniel Hornburg, Mareike Czuppa, Jakob Bader, Meike Michaelsen, Daniel Farny, Thomas Arzberger, Matthias Mann, Felix Meissner, Dieter Edbauer
Life Science Alliance May 2018, 1 (2) e201800070; DOI: 10.26508/lsa.201800070

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Poly-GR/PR interactome
Hannelore Hartmann, Daniel Hornburg, Mareike Czuppa, Jakob Bader, Meike Michaelsen, Daniel Farny, Thomas Arzberger, Matthias Mann, Felix Meissner, Dieter Edbauer
Life Science Alliance May 2018, 1 (2) e201800070; DOI: 10.26508/lsa.201800070
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Volume 1, No. 2
May 2018
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  • Nucleocytoplasmic Proteomic Analysis Uncovers eRF1 and Nonsense Mediated Decay as Modifiers of ALS C9orf72 Toxicity
  • C9orf72-associated arginine-rich dipeptide repeats induce RNA-dependent accumulation of Staufen in nucleus
  • A role of cellular translation regulation associated with toxic Huntingtin protein
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