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Research Articles
Regulation of microtubule dynamic instability by the carboxy-terminal tail of β-tubulinThis work examines how the carboxy-terminal tail domain of β-tubulin governs microtubule dynamic instability and the structure of plus ends using complementary in vivo and in vitro experiments.
β-Tubulin carboxy-terminal tails exhibit isotype-specific effects on microtubule dynamics in human gene-edited cellsThis study used human gene-edited cell models and image analysis to reveal that the tubulin C-terminal tails specifically regulate the dynamics of individual microtubules and coordinate microtubule behavior across the cell.
Pervasive allele-specific regulation on RNA decay in hybrid miceUsing a F1 hybrid mouse system, this study globally investigates the effects of cis-regulatory divergence on RNA decay in mammals and reveals the evolutionary roles of RNA decay regulation.
Proteomics and C9orf72 neuropathology identify ribosomes as poly-GR/PR interactors driving toxicityProteomics and neuropathological validation show that aberrant poly-GR/PR proteins in C9orf72 ALS/FTD bind STAU2 and ribosomes and inhibit translation.
Multiple membrane extrusion sites drive megakaryocyte migration into bone marrow blood vesselsMegakaryocytes enter bone marrow sinusoids to generate platelets by extrusion of internal membrane into the plasma membrane at fusion sites rather than microtubule-driven proplatelet extension.
Serine catabolism is essential to maintain mitochondrial respiration in mammalian cellsMitochondrial respiratory complex assembly requires the one-carbon unit generated from serine catabolism.
The Arabidopsis homolog of human G3BP1 is a key regulator of stomatal and apoplastic immunityArabidopsis homolog of human G3BP1 negatively regulates plant immunity and defense responses. Atg3bp1 mutant lines show constitutive stomata closure, expression of a number of key defense marker genes, and accumulate salicylic acid.
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Multi-region proteome analysis quantifies spatial heterogeneity of prostate tissue biomarkersApplication of pressure cycling technology and Sequential Windowed Acquisition of all THeoretical mass spectrometry allows quantifying the degree of intra-tumor heterogeneity of protein expression in prostate tumors. The data show that protein intra-tumor heterogeneity, if not characterized, may distort protein biomarker suitability in tumor tissues.
