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Table of Contents

May 2018 | Volume 1, No. 2

Research Articles

  • Regulation of microtubule dynamic instability by the carboxy-terminal tail of β-tubulin
    Open Access
    Regulation of microtubule dynamic instability by the carboxy-terminal tail of β-tubulin

    Colby P Fees, Jeffrey K Moore

    Colby P Fees ... Jeffrey K Moore

    Published 19 April 2018

    This work examines how the carboxy-terminal tail domain of β-tubulin governs microtubule dynamic instability and the structure of plus ends using complementary in vivo and in vitro experiments.

  • β-Tubulin carboxy-terminal tails exhibit isotype-specific effects on microtubule dynamics in human gene-edited cells
    Open Access
    β-Tubulin carboxy-terminal tails exhibit isotype-specific effects on microtubule dynamics in human gene-edited cells

    Amelia L Parker, Wee Siang Teo, Elvis Pandzic, Juan Jesus Vicente, Joshua A McCarroll, Linda Wordeman, Maria Kavallaris

    Amelia L Parker ... Maria Kavallaris

    Published 19 April 2018

    This study used human gene-edited cell models and image analysis to reveal that the tubulin C-terminal tails specifically regulate the dynamics of individual microtubules and coordinate microtubule behavior across the cell.

  • Pervasive allele-specific regulation on RNA decay in hybrid mice
    Open Access
    Pervasive allele-specific regulation on RNA decay in hybrid mice

    Wei Sun, Qingsong Gao, Bernhard Schaefke, Yuhui Hu, Wei Chen

    Wei Sun ... Wei Chen

    Published 16 May 2018

    Using a F1 hybrid mouse system, this study globally investigates the effects of cis-regulatory divergence on RNA decay in mammals and reveals the evolutionary roles of RNA decay regulation.

  • Proteomics and <em>C9orf72</em> neuropathology identify ribosomes as poly-GR/PR interactors driving toxicity
    Open Access
    Proteomics and C9orf72 neuropathology identify ribosomes as poly-GR/PR interactors driving toxicity

    Hannelore Hartmann, Daniel Hornburg, Mareike Czuppa, Jakob Bader, Meike Michaelsen, Daniel Farny, Thomas Arzberger, Matthias Mann, Felix Meissner, Dieter Edbauer

    Hannelore Hartmann ... Dieter Edbauer

    Published 16 May 2018

    Proteomics and neuropathological validation show that aberrant poly-GR/PR proteins in C9orf72 ALS/FTD bind STAU2 and ribosomes and inhibit translation.

  • Multiple membrane extrusion sites drive megakaryocyte migration into bone marrow blood vessels
    Open Access
    Multiple membrane extrusion sites drive megakaryocyte migration into bone marrow blood vessels

    Edward Brown, Leo M Carlin, Claus Nerlov, Cristina Lo Celso, Alastair W Poole

    Edward Brown ... Alastair W Poole

    Published 21 May 2018

    Megakaryocytes enter bone marrow sinusoids to generate platelets by extrusion of internal membrane into the plasma membrane at fusion sites rather than microtubule-driven proplatelet extension.

  • Serine catabolism is essential to maintain mitochondrial respiration in mammalian cells
    Open Access
    Serine catabolism is essential to maintain mitochondrial respiration in mammalian cells

    Stephanie Lucas, Guohua Chen, Siddhesh Aras, Jian Wang

    Stephanie Lucas ... Jian Wang

    Published 21 May 2018

    Mitochondrial respiratory complex assembly requires the one-carbon unit generated from serine catabolism.

  • The <em>Arabidopsis</em> homolog of human G3BP1 is a key regulator of stomatal and apoplastic immunity
    Open Access
    The Arabidopsis homolog of human G3BP1 is a key regulator of stomatal and apoplastic immunity

    Aala A Abulfaraj, Kiruthiga Mariappan, Jean Bigeard, Prabhu Manickam, Ikram Blilou, Xiujie Guo, Salim Al-Babili, Delphine Pflieger, Heribert Hirt, Naganand Rayapuram

    Aala A Abulfaraj ... Naganand Rayapuram

    Published 31 May 2018

    Arabidopsis homolog of human G3BP1 negatively regulates plant immunity and defense responses. Atg3bp1 mutant lines show constitutive stomata closure, expression of a number of key defense marker genes, and accumulate salicylic acid.

Resource

  • Multi-region proteome analysis quantifies spatial heterogeneity of prostate tissue biomarkers
    Open Access
    Multi-region proteome analysis quantifies spatial heterogeneity of prostate tissue biomarkers

    Tiannan Guo, Li Li, Qing Zhong, Niels J Rupp, Konstantina Charmpi, Christine E Wong, Ulrich Wagner, Jan H Rueschoff, Wolfram Jochum, Christian Daniel Fankhauser, Karim Saba, Cedric Poyet, Peter J Wild, Ruedi Aebersold, Andreas Beyer

    Tiannan Guo ... Andreas Beyer

    Published 29 May 2018

    Application of pressure cycling technology and Sequential Windowed Acquisition of all THeoretical mass spectrometry allows quantifying the degree of intra-tumor heterogeneity of protein expression in prostate tumors. The data show that protein intra-tumor heterogeneity, if not characterized, may distort protein biomarker suitability in tumor tissues.

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Volume 1, No. 2
May 2018
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