Table of Contents
Editorials
Introducing Life Science AllianceA new open-access journal by leading not-for-profit research institutions focusing on quality and reliability with a rigorous, transparent, and academically driven peer-review process.
- Life Science Alliance, from the Academic Editors
Life Science Alliance is a community-driven journal that brings together research from diverse fields. The journal is first-of-its-kind in uniting not-for-profit publishers and employing the scientific community to change the way authors can publish their work.
Research Articles
The ER morphology-regulating lunapark protein induces the formation of stacked bilayer discsLunapark, an ER protein implicated in stabilizing junctions of the tubular network and regulating morphology changes during mitosis, forms stacked bilayer discs upon reconstitution with phospholipids.
CHRAC/ACF contribute to the repressive ground state of chromatinChromatin accessibility complex/ATP-utilizing chromatin assembly and remodeling factor help to establish basal transcriptional repression, conceivably through improving the regular spacing of nucleosomes in euchromatin.
BACE2 distribution in major brain cell types and identification of novel substratesβ-Site APP-cleaving enzyme 1 (BACE1) inhibition to treat Alzheimer’s disease also inhibits BACE2. This work shows BACE2 expression in the mouse brain and identifies its substrates. Increased BACE2 processing of vascular cell adhesion molecule 1 during inflammatory conditions cautions the use of current nonspecific BACE1 inhibitors in the clinic.
The expansion in lymphoid organs of IL-4+ BATF+ T follicular helper cells is linked to IgG4 class switching in vivoT follicular helper cells that secrete IL-4 accumulate in lymphoid organs in IgG4-related disease and are linked to IgG4 class switching.
