BACE2 distribution in major brain cell types and identification of novel substrates

Iryna Voytyuk; Stephan A Mueller; Julia Herber; An Snellinx; Dieder Moechars; Geert van Loo; Stefan F Lichtenthaler; Bart De Strooper

doi:10.26508/lsa.201800026

Research Article

Open Access

BACE2 distribution in major brain cell types and identification of novel substrates

Iryna Voytyuk, Stephan A Mueller, Julia Herber, An Snellinx, Dieder Moechars, View ORCID ProfileGeert van Loo, Stefan F Lichtenthaler, View ORCID ProfileBart De Strooper Correspondence email

Iryna Voytyuk

1Department of Neurosciences, Katholieke Universiteit Leuven, Leuven, Belgium

2Centre for Brain and Disease Research, Flanders Institute for Biotechnology (VIB), Leuven, Belgium

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Stephan A Mueller

3German Center for Neurodegenerative Diseases (DZNE), Munich, Germany

4Neuroproteomics, School of Medicine, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany

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Julia Herber

3German Center for Neurodegenerative Diseases (DZNE), Munich, Germany

4Neuroproteomics, School of Medicine, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany

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An Snellinx

1Department of Neurosciences, Katholieke Universiteit Leuven, Leuven, Belgium

2Centre for Brain and Disease Research, Flanders Institute for Biotechnology (VIB), Leuven, Belgium

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Dieder Moechars

5Discovery Neuroscience, Janssen Research and Development, Division of Janssen Pharmaceutica NV, Beerse, Belgium

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Geert van Loo

6Center for Inflammation Research, VIB, Gent, Belgium

7Department of Biomedical Molecular Biology, Gent University, Gent, Belgium

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ORCID record for Geert van Loo

Stefan F Lichtenthaler

3German Center for Neurodegenerative Diseases (DZNE), Munich, Germany

4Neuroproteomics, School of Medicine, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany

8Institute for Advanced Study, Technische Universität München, Munich, Germany

9Munich Cluster for Systems Neurology, Munich, Germany

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Bart De Strooper

1Department of Neurosciences, Katholieke Universiteit Leuven, Leuven, Belgium

2Centre for Brain and Disease Research, Flanders Institute for Biotechnology (VIB), Leuven, Belgium

9Munich Cluster for Systems Neurology, Munich, Germany

10Dementia Research Institute, Institute of Neurology, University College London, London, UK

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ORCID record for Bart De Strooper
For correspondence: Bart.DeStrooper@kuleuven.vib.be

Published 15 February 2018. DOI: 10.26508/lsa.201800026

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BACE2 brain expression and substrates