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Research Article
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BACE2 distribution in major brain cell types and identification of novel substrates

Iryna Voytyuk, Stephan A Mueller, Julia Herber, An Snellinx, Dieder Moechars, View ORCID ProfileGeert van Loo, Stefan F Lichtenthaler, View ORCID ProfileBart De Strooper  Correspondence email
Iryna Voytyuk
1Department of Neurosciences, Katholieke Universiteit Leuven, Leuven, Belgium
2Centre for Brain and Disease Research, Flanders Institute for Biotechnology (VIB), Leuven, Belgium
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Stephan A Mueller
3German Center for Neurodegenerative Diseases (DZNE), Munich, Germany
4Neuroproteomics, School of Medicine, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany
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Julia Herber
3German Center for Neurodegenerative Diseases (DZNE), Munich, Germany
4Neuroproteomics, School of Medicine, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany
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An Snellinx
1Department of Neurosciences, Katholieke Universiteit Leuven, Leuven, Belgium
2Centre for Brain and Disease Research, Flanders Institute for Biotechnology (VIB), Leuven, Belgium
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Dieder Moechars
5Discovery Neuroscience, Janssen Research and Development, Division of Janssen Pharmaceutica NV, Beerse, Belgium
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Geert van Loo
6Center for Inflammation Research, VIB, Gent, Belgium
7Department of Biomedical Molecular Biology, Gent University, Gent, Belgium
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  • ORCID record for Geert van Loo
Stefan F Lichtenthaler
3German Center for Neurodegenerative Diseases (DZNE), Munich, Germany
4Neuroproteomics, School of Medicine, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany
8Institute for Advanced Study, Technische Universität München, Munich, Germany
9Munich Cluster for Systems Neurology, Munich, Germany
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Bart De Strooper
1Department of Neurosciences, Katholieke Universiteit Leuven, Leuven, Belgium
2Centre for Brain and Disease Research, Flanders Institute for Biotechnology (VIB), Leuven, Belgium
9Munich Cluster for Systems Neurology, Munich, Germany
10Dementia Research Institute, Institute of Neurology, University College London, London, UK
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  • ORCID record for Bart De Strooper
  • For correspondence: Bart.DeStrooper@kuleuven.vib.be
Published 15 February 2018. DOI: 10.26508/lsa.201800026
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Article Information

vol. 1 no. 1 e201800026
DOI 
https://doi.org/10.26508/lsa.201800026
PubMed 
30456346

Published By 
Life Science Alliance
Online ISSN 
2575-1077
History 
  • Received January 29, 2018
  • Revision received January 29, 2018
  • Accepted February 1, 2018
  • Published online February 15, 2018.

Copyright & Usage 
© 2018 Voytyuk et al. This article is available under a Creative Commons License (Attribution 4.0 International, as described at https://creativecommons.org/licenses/by/4.0/).

Author Information

  1. Iryna Voytyuk1,2,
  2. Stephan A Mueller3,4,
  3. Julia Herber3,4,
  4. An Snellinx1,2,
  5. Dieder Moechars5,
  6. Geert van Loo6,7,
  7. Stefan F Lichtenthaler3,4,8,9 and
  8. Bart De Strooper1,2,9,10⇑
  1. 1Department of Neurosciences, Katholieke Universiteit Leuven, Leuven, Belgium
  2. 2Centre for Brain and Disease Research, Flanders Institute for Biotechnology (VIB), Leuven, Belgium
  3. 3German Center for Neurodegenerative Diseases (DZNE), Munich, Germany
  4. 4Neuroproteomics, School of Medicine, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany
  5. 5Discovery Neuroscience, Janssen Research and Development, Division of Janssen Pharmaceutica NV, Beerse, Belgium
  6. 6Center for Inflammation Research, VIB, Gent, Belgium
  7. 7Department of Biomedical Molecular Biology, Gent University, Gent, Belgium
  8. 8Institute for Advanced Study, Technische Universität München, Munich, Germany
  9. 9Munich Cluster for Systems Neurology, Munich, Germany
  10. 10Dementia Research Institute, Institute of Neurology, University College London, London, UK
  1. Correspondence: Bart.DeStrooper{at}kuleuven.vib.be
View Full Text

Funding

  • Agency for Innovation by Science and Technology (IWT), Stichting Alzheimer Onderzoek (SAO), Fund for Scientific Research, KU Leuven, Flemish Government

  • Vlaams Initiatief voor Netwerken voor Dementie Onderzoek

    135043
  • Deutsche Forschungsgemeinschaft

    FG2290
  • Leuven Universiteit Fonds

    B De Strooper
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BACE2 brain expression and substrates
Iryna Voytyuk, Stephan A Mueller, Julia Herber, An Snellinx, Dieder Moechars, Geert van Loo, Stefan F Lichtenthaler, Bart De Strooper
Life Science Alliance Feb 2018, 1 (1) e201800026; DOI: 10.26508/lsa.201800026

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BACE2 brain expression and substrates
Iryna Voytyuk, Stephan A Mueller, Julia Herber, An Snellinx, Dieder Moechars, Geert van Loo, Stefan F Lichtenthaler, Bart De Strooper
Life Science Alliance Feb 2018, 1 (1) e201800026; DOI: 10.26508/lsa.201800026
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Volume 1, No. 1
January 2018
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