Chromatin & Epigenetics
Chromosome length and gene density contribute to micronuclear membrane stabilityChromosome identity regulates the timing of nuclear membrane rupture in micronuclei, in part through an unexpected link between high gene density and improved nuclear lamina organization.
PROSER1 mediates TET2 O-GlcNAcylation to regulate DNA demethylation on UTX-dependent enhancers and CpG islandsPROSER1 promotes the interaction between TET2 and the glycosyltransferase OGT to regulate TET2 O-GlcNAcylation and stability on genomic elements that depend on the activity of the MLL3/4 complexes.
HERVH-derived lncRNAs negatively regulate chromatin targeting and remodeling mediated by CHD7Mutations in CHD7 are diagnostic for human CHARGE syndrome. RNAs expressed from the HERVH repeats modulate CHD7 function providing one mechanism for regulation of differentiation of pluripotent cells.
Set4 regulates stress response genes and coordinates histone deacetylases within yeast subtelomeresThe yeast chromatin protein Set4 regulates expression of stress response genes within subtelomeric regions under normal and stress conditions and modulates histone deacetylase activity at chromatin.
ATAD2 controls chromatin-bound HIRA turnoverParallel study of multiple model systems points to the evolutionary conserved protein ATAD2, as a critical histone chaperone auxiliary factor.
Ccq1–Raf2 interaction mediates CLRC recruitment to establish heterochromatin at telomeresThis study unveils a role of Ccq1–Raf2 interaction in CLRC recruitment to establish heterochromatin at telomeres, providing a positive feedback mechanism between shelterin and CLRC for subtelomeric heterochromatin assembly.
Glucocorticoid signaling induces transcriptional memory and universally reversible chromatin changesGlucocorticoids are stress hormones that elicit various cellular responses. These responses are typically reversible; however, in some instances, a previous exposure is “remembered” and influences the response to a subsequent hormone encounter.
Distinct mechanisms mediate X chromosome dosage compensation in Anopheles and DrosophilaCRISPR knockout of msl-2 and epigenome analyses in Anopheles reveal that X chromosome dosage compensation in mosquitos and Drosophila is achieved by two different molecular mechanisms.
Hierarchical dinucleotide distribution in genome along evolution and its effect on chromatin packingIt describes how hierarchical CpG distribution on the genomes of species change in the evolution and the correlation with the chromatin structure.
A role for condensin in mediating transcriptional adaptation to environmental stimuliFast conditional depletion of the chromosomal condensin complex from budding yeast cells reveals roles in transcriptional regulation, especially during the establishment of new gene expression patterns.