Chromatin & Epigenetics
- Set4 regulates stress response genes and coordinates histone deacetylases within yeast subtelomeres
The yeast chromatin protein Set4 regulates expression of stress response genes within subtelomeric regions under normal and stress conditions and modulates histone deacetylase activity at chromatin.
- ATAD2 controls chromatin-bound HIRA turnover
Parallel study of multiple model systems points to the evolutionary conserved protein ATAD2, as a critical histone chaperone auxiliary factor.
- Ccq1–Raf2 interaction mediates CLRC recruitment to establish heterochromatin at telomeres
This study unveils a role of Ccq1–Raf2 interaction in CLRC recruitment to establish heterochromatin at telomeres, providing a positive feedback mechanism between shelterin and CLRC for subtelomeric heterochromatin assembly.
- Glucocorticoid signaling induces transcriptional memory and universally reversible chromatin changes
Glucocorticoids are stress hormones that elicit various cellular responses. These responses are typically reversible; however, in some instances, a previous exposure is “remembered” and influences the response to a subsequent hormone encounter.
- Distinct mechanisms mediate X chromosome dosage compensation in Anopheles and Drosophila
CRISPR knockout of msl-2 and epigenome analyses in Anopheles reveal that X chromosome dosage compensation in mosquitos and Drosophila is achieved by two different molecular mechanisms.
- Hierarchical dinucleotide distribution in genome along evolution and its effect on chromatin packing
It describes how hierarchical CpG distribution on the genomes of species change in the evolution and the correlation with the chromatin structure.
- A role for condensin in mediating transcriptional adaptation to environmental stimuli
Fast conditional depletion of the chromosomal condensin complex from budding yeast cells reveals roles in transcriptional regulation, especially during the establishment of new gene expression patterns.
- Gametic specialization of centromeric histone paralogs in Drosophila virilis
Somatic and germline centromeric functions could differ because of different chromatin environments in male and female gametes versus somatic cells. We show that two different centromeric histone paralogs are alternately retained in male versus female gametes in many Drosophila species.
- In utero exposure to chlordecone affects histone modifications and activates LINE-1 in cord blood
In utero exposure to chlordecone affects chromatin and leads to activation of retroelements. This study shows the changes induced by chlordecone in human umbilical cord blood and blood-derived cell line.
- Replicated chromatin curtails 53BP1 recruitment in BRCA1-proficient and BRCA1-deficient cells
This study demonstrates how single cell normalization to genome size provides insight into genome function, here in the context of DNA double-strand break repair by 53BP1 versus BRCA1–BARD1.