Chromatin & Epigenetics
BRG1 HSA domain interactions with BCL7 proteins are critical for remodeling and gene expressionInteractions between the BRG1 HSA domain and the B-cell CLL/lymphoma 7 proteins facilitate BRG1-mediated chromatin remodeling and induce changes in the gene expression of essential biological pathways.
Aberrant association of chromatin with nuclear periphery induced by Rif1 leads to mitotic defectOverexpression of Rif1 induces relocation of chromatin to nuclear periphery and mitotic defect, suggesting a role of regulated chromatin–nuclear membrane association in the proper progression of M phase.
The organizer of chromatin topology RIF1 ensures cellular resilience to DNA replication stressThe conserved protein RIF1 stabilizes replication factories and regulates cohesin recruitment in response to replication stress to limit DNA lesions.
Epigenetic signals that direct cell type–specific interferon beta response in mouse cellsPreexisting cell type–specific chromatin features represent an additional regulatory layer for interferon beta response and direct binding of STAT transcription factors and gene induction.
Plant mobile domain proteins ensure Microrchidia 1 expression to fulfill transposon silencingThe plant mobile domain proteins MAIN and MAIL1 control the expression of the epigenetic factor Microrchidia 1, which has been involved in transposable element silencing in Arabidopsis.
Regulation of telomere silencing by the core histones–autophagy–Sir2 axisThis work reported that there is a global loss of core histones and progressively reduced telomere silencing during yeast chronological aging and uncovered the core histones-autophagy-Sir2 pathway that contributes to the aging-coupled loss of telomere silencing.
De novo discovery of traits co-occurring with chronic obstructive pulmonary diseaseThis paper integrates different levels of biological information to identify shared genetic and biological pathways underlying the diverse clinical presentations of COPD. Thus, it identifies a collection of genetic variants and genes that may aid COPD patient stratification and treatment.
ZBTB18 inhibits SREBP-dependent lipid synthesis by halting CTBPs and LSD1 activity in glioblastomaThis study identifies a new mechanism of fatty acid synthesis regulation in glioblastoma that involves ZBTB18, CTBP, and LSD1. The transcriptional repressor ZBTB18 interacts with CTBP and inhibits LSD1 demethylase activity.
Genome-wide profiling of histone modifications in Plasmodium falciparum using CUT&RUNWe present a detailed step-wise protocol for reliable genome-wide profiling of histone modifications using CUT&RUN that requires only low numbers of Plasmodium falciparum blood stages.
A critique of the hypothesis that CA repeats are primary targets of neuronal MeCP2Using relevant neuronal datasets and in vitro experiments, we show that MeCP2 function depends on methylated CAC (mCAC) sites regardless of their occurrence in CA repeats or elsewhere in the genome.