Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Newest Articles
    • Current Issue
    • Archive
    • Subjects
  • Submit
    • Submit a Manuscript
    • Author Guidelines
    • License, Copyright, Fee
    • FAQ
    • Why Submit
  • About
    • About Us
    • Editors & Staff
    • Board Members
    • Licensing and Reuse
    • Reviewer Guidelines
    • Privacy Policy
    • Advertise
    • Contact Us
    • LSA LLC
  • Alerts
  • Other Publications
    • EMBO Press
    • The EMBO Journal
    • EMBO reports
    • EMBO Molecular Medicine
    • Molecular Systems Biology
    • Rockefeller University Press
    • Journal of Cell Biology
    • Journal of Experimental Medicine
    • Journal of General Physiology
    • Cold Spring Harbor Laboratory Press
    • Genes & Development
    • Genome Research

User menu

  • My alerts

Search

  • Advanced search
Life Science Alliance
  • Other Publications
    • EMBO Press
    • The EMBO Journal
    • EMBO reports
    • EMBO Molecular Medicine
    • Molecular Systems Biology
    • Rockefeller University Press
    • Journal of Cell Biology
    • Journal of Experimental Medicine
    • Journal of General Physiology
    • Cold Spring Harbor Laboratory Press
    • Genes & Development
    • Genome Research
  • My alerts
Life Science Alliance

Advanced Search

  • Home
  • Articles
    • Newest Articles
    • Current Issue
    • Archive
    • Subjects
  • Submit
    • Submit a Manuscript
    • Author Guidelines
    • License, Copyright, Fee
    • FAQ
    • Why Submit
  • About
    • About Us
    • Editors & Staff
    • Board Members
    • Licensing and Reuse
    • Reviewer Guidelines
    • Privacy Policy
    • Advertise
    • Contact Us
    • LSA LLC
  • Alerts
  • Follow lsa Template on Twitter

Chromatin & Epigenetics

  • Mitochondrial acetyl-CoA reversibly regulates locus-specific histone acetylation and gene expression
    Open Access
    Mitochondrial acetyl-CoA reversibly regulates locus-specific histone acetylation and gene expression

    Oswaldo A Lozoya, Tianyuan Wang, Dagoberto Grenet, Taylor C Wolfgang, Mack Sobhany, Douglas Ganini da Silva, Gonzalo Riadi, Navdeep Chandel, Richard P Woychik, Janine H Santos

    Oswaldo A Lozoya ... Janine H Santos

    Published 8 February 2019

    This study shows that genetic or pharmacological manipulation of the TCA cycle, when mitochondria are dysfunctional, can modulate histone acetylation and gene expression in the nucleus with physiological outcomes.

  • Polycomb and Notch signaling regulate cell proliferation potential during <em>Caenorhabditis elegans</em> life cycle
    Open Access
    Polycomb and Notch signaling regulate cell proliferation potential during Caenorhabditis elegans life cycle

    Francesca Coraggio, Ringo Püschel, Alisha Marti, Peter Meister

    Francesca Coraggio ... Peter Meister

    Published 26 December 2018

    Caenorhabditis elegans lineage is invariant between animals. By challenging cell fate in differentiated worms, an unexpected role of Polycomb and Notch signaling in the control of cell proliferation was uncovered, suggesting that the lineage is more flexible than believed.

  • Variants of <em>DNMT3A</em> cause transcript-specific DNA methylation patterns and affect hematopoiesis
    Open Access
    Variants of DNMT3A cause transcript-specific DNA methylation patterns and affect hematopoiesis

    Tanja Božić, Joana Frobel, Annamarija Raic, Fabio Ticconi, Chao-Chung Kuo, Stefanie Heilmann-Heimbach, Tamme W Goecke, Martin Zenke, Edgar Jost, Ivan G Costa, Wolfgang Wagner

    Tanja Božić ... Wolfgang Wagner

    Published 13 December 2018

    Modulation of DNMT3A splice variants causes transcript-specific DNA methylation and gene expression changes and affects differentiation. Particularly, transcript 2 is relevant in acute myeloid leukemia.

  • A role for MED14 and UVH6 in heterochromatin transcription upon destabilization of silencing
    Open Access
    A role for MED14 and UVH6 in heterochromatin transcription upon destabilization of silencing

    Pierre Bourguet, Stève de Bossoreille, Leticia López-González, Marie-Noëlle Pouch-Pélissier, Ángeles Gómez-Zambrano, Anthony Devert, Thierry Pélissier, Romain Pogorelcnik, Isabelle Vaillant, Olivier Mathieu

    Pierre Bourguet ... Olivier Mathieu

    Published 12 December 2018

    The TFIIH component UVH6 and the mediator subunit MED14 are differentially required for the release of heterochromatin silencing, and MED14 regulates non-CG DNA methylation in Arabidopsis.

  • Topological in vitro loading of the budding yeast cohesin ring onto DNA
    Open Access
    Topological in vitro loading of the budding yeast cohesin ring onto DNA

    Masashi Minamino, Torahiko L Higashi, Céline Bouchoux, Frank Uhlmann

    Masashi Minamino ... Frank Uhlmann

    Published 26 October 2018

    The biochemical reconstitution of topological DNA binding by budding yeast cohesin yields surprises and opens opportunities to exploit experimental approaches developed in this model organism.

  • Loss of HDAC11 ameliorates clinical symptoms in a multiple sclerosis mouse model
    Open Access
    Loss of HDAC11 ameliorates clinical symptoms in a multiple sclerosis mouse model

    Lei Sun, Elphine Telles, Molly Karl, Fengdong Cheng, Noreen Luetteke, Eduardo M Sotomayor, Robert H Miller, Edward Seto

    Lei Sun ... Edward Seto

    Published 24 September 2018

    In an animal model for multiple sclerosis, the absence of HDAC11 reduces clinical severity, spinal cord demyelination, and immune cell infiltration, suggesting that HDAC11 is a promising target for MS treatment.

  • Transformation-induced stress at telomeres is counteracted through changes in the telomeric proteome including SAMHD1
    Open Access
    Transformation-induced stress at telomeres is counteracted through changes in the telomeric proteome including SAMHD1

    Jana Majerska, Marianna Feretzaki, Galina Glousker, Joachim Lingner

    Jana Majerska ... Joachim Lingner

    Published 17 July 2018

    The authors apply telomeric chromatin analysis to identify factors that accumulate at telomeres during cellular transformation, promoting telomere replication and repair and counteracting oncogene-borne telomere replication stress.

  • The histone chaperone FACT modulates nucleosome structure by tethering its components
    Open Access
    The histone chaperone FACT modulates nucleosome structure by tethering its components

    Tao Wang, Yang Liu, Garrett Edwards, Daniel Krzizike, Hataichanok Scherman, Karolin Luger

    Tao Wang ... Karolin Luger

    Published 10 July 2018

    The histone chaperone FACT functions by tethering partial components of the nucleosome, thereby assisting nucleosome disassembly and reassembly during transcription.

  • Somatic role of SYCE2: an insulator that dissociates HP1α from H3K9me3 and potentiates DNA repair
    Open Access
    Somatic role of SYCE2: an insulator that dissociates HP1α from H3K9me3 and potentiates DNA repair

    Noriko Hosoya, Masato Ono, Kiyoshi Miyagawa

    Noriko Hosoya ... Kiyoshi Miyagawa

    Published 22 June 2018

    This study reveals that the synaptonemal complex protein SYCE2 potentiates ataxia telangiectasia mutated–mediated DNA double-strand break repair by dissociating HP1α from trimethylated histone H3 lysine 9 in somatic cells.

  • Transcriptional repression by FACT is linked to regulation of chromatin accessibility at the promoter of ES cells
    Open Access
    Transcriptional repression by FACT is linked to regulation of chromatin accessibility at the promoter of ES cells

    Constantine Mylonas, Peter Tessarz

    Constantine Mylonas ... Peter Tessarz

    Published 13 June 2018

    Depletion of FACT in murine embryonic stem cells show mild changes on the nucleosomal landscape but widespread changes in the transcriptome, faster proliferation, and neuronal differentiation rates.

Pages

  • Previous
  • Next
  • 1
  • 2
  • 3
  • 4
  • Aging (10)
  • Biophysics (14)
  • Cancer (67)
  • Cell Biology (147)
  • Chemical Biology (7)
  • Chromatin & Epigenetics (31)
  • Development (28)
  • Ecology (1)
  • Evolution (10)
  • Genetics, Gene Therapy & Genetic Disease (32)
  • Genomics & Functional Genomics (45)
  • Immunology (62)
  • Medical Research (31)
  • Metabolism (22)
  • Methods & Resources (24)
  • Microbiology, Virology & Host Pathogen Interaction (46)
  • Molecular Biology (98)
  • Molecular Diagnostics & Diagnostic Imaging (2)
  • Neuroscience (36)
  • Pharmacology & Biotechnology (8)
  • Physiology (11)
  • Plant Science (11)
  • Stem Cells (25)
  • Structural Biology (27)
  • Synthetic Biology (2)
  • Systems & Computational Biology (36)
Advertisement

EMBO Press LogoRockefeller University Press LogoCold Spring Harbor Logo

Content

  • Home
  • Newest Articles
  • Current Issue
  • Archive
  • Subject Collections

For Authors

  • Submit a Manuscript
  • Author Guidelines
  • License, copyright, Fee

Other Services

  • Alerts
  • Twitter
  • RSS Feeds

More Information

  • Editors & Staff
  • Reviewer Guidelines
  • Feedback
  • Licensing and Reuse
  • Privacy Policy

ISSN: 2575-1077
© 2021 Life Science Alliance LLC

Life Science Alliance is registered as a trademark in the U.S. Patent and Trade Mark Office and in the European Union Intellectual Property Office.