Chromatin & Epigenetics
Mitochondrial acetyl-CoA reversibly regulates locus-specific histone acetylation and gene expressionThis study shows that genetic or pharmacological manipulation of the TCA cycle, when mitochondria are dysfunctional, can modulate histone acetylation and gene expression in the nucleus with physiological outcomes.
Polycomb and Notch signaling regulate cell proliferation potential during Caenorhabditis elegans life cycleCaenorhabditis elegans lineage is invariant between animals. By challenging cell fate in differentiated worms, an unexpected role of Polycomb and Notch signaling in the control of cell proliferation was uncovered, suggesting that the lineage is more flexible than believed.
Variants of DNMT3A cause transcript-specific DNA methylation patterns and affect hematopoiesisModulation of DNMT3A splice variants causes transcript-specific DNA methylation and gene expression changes and affects differentiation. Particularly, transcript 2 is relevant in acute myeloid leukemia.
A role for MED14 and UVH6 in heterochromatin transcription upon destabilization of silencingThe TFIIH component UVH6 and the mediator subunit MED14 are differentially required for the release of heterochromatin silencing, and MED14 regulates non-CG DNA methylation in Arabidopsis.
Topological in vitro loading of the budding yeast cohesin ring onto DNAThe biochemical reconstitution of topological DNA binding by budding yeast cohesin yields surprises and opens opportunities to exploit experimental approaches developed in this model organism.
Loss of HDAC11 ameliorates clinical symptoms in a multiple sclerosis mouse modelIn an animal model for multiple sclerosis, the absence of HDAC11 reduces clinical severity, spinal cord demyelination, and immune cell infiltration, suggesting that HDAC11 is a promising target for MS treatment.
Transformation-induced stress at telomeres is counteracted through changes in the telomeric proteome including SAMHD1The authors apply telomeric chromatin analysis to identify factors that accumulate at telomeres during cellular transformation, promoting telomere replication and repair and counteracting oncogene-borne telomere replication stress.
The histone chaperone FACT modulates nucleosome structure by tethering its componentsThe histone chaperone FACT functions by tethering partial components of the nucleosome, thereby assisting nucleosome disassembly and reassembly during transcription.
Somatic role of SYCE2: an insulator that dissociates HP1α from H3K9me3 and potentiates DNA repairThis study reveals that the synaptonemal complex protein SYCE2 potentiates ataxia telangiectasia mutated–mediated DNA double-strand break repair by dissociating HP1α from trimethylated histone H3 lysine 9 in somatic cells.
Transcriptional repression by FACT is linked to regulation of chromatin accessibility at the promoter of ES cellsDepletion of FACT in murine embryonic stem cells show mild changes on the nucleosomal landscape but widespread changes in the transcriptome, faster proliferation, and neuronal differentiation rates.