Chromatin & Epigenetics
Loss of HDAC11 ameliorates clinical symptoms in a multiple sclerosis mouse modelIn an animal model for multiple sclerosis, the absence of HDAC11 reduces clinical severity, spinal cord demyelination, and immune cell infiltration, suggesting that HDAC11 is a promising target for MS treatment.
Transformation-induced stress at telomeres is counteracted through changes in the telomeric proteome including SAMHD1The authors apply telomeric chromatin analysis to identify factors that accumulate at telomeres during cellular transformation, promoting telomere replication and repair and counteracting oncogene-borne telomere replication stress.
The histone chaperone FACT modulates nucleosome structure by tethering its componentsThe histone chaperone FACT functions by tethering partial components of the nucleosome, thereby assisting nucleosome disassembly and reassembly during transcription.
Somatic role of SYCE2: an insulator that dissociates HP1α from H3K9me3 and potentiates DNA repairThis study reveals that the synaptonemal complex protein SYCE2 potentiates ataxia telangiectasia mutated–mediated DNA double-strand break repair by dissociating HP1α from trimethylated histone H3 lysine 9 in somatic cells.
Transcriptional repression by FACT is linked to regulation of chromatin accessibility at the promoter of ES cellsDepletion of FACT in murine embryonic stem cells show mild changes on the nucleosomal landscape but widespread changes in the transcriptome, faster proliferation, and neuronal differentiation rates.
CHRAC/ACF contribute to the repressive ground state of chromatinChromatin accessibility complex/ATP-utilizing chromatin assembly and remodeling factor help to establish basal transcriptional repression, conceivably through improving the regular spacing of nucleosomes in euchromatin.