Chromatin & Epigenetics
p53 ensures the normal behavior and modification of G1/S-specific histone H3.1 in the nucleusp53 down-regulates nuclear phosphatidic acid levels to avoid the aberrant accumulation and modification of histone H3.1 during the G1/S phase, in which p53-mediated induction of a specific gene is the initial step.
Single-housing–induced islet epigenomic changes are related to polymorphisms in diabetic KK miceThis study demonstrates that non-coding variants in KK mice, a polygenic model of type 2 diabetes, may be involved in the development of diabetes via epigenetic mechanisms during social isolation.
The importance of DNA sequence for nucleosome positioning in transcriptional regulationMachine learning on DNA sequences shows that nucleosomes are positioned by DNA sequence patterns to support the stages of transcription by directing competition between nucleosomes and transcription factors, as well as regulating RNA polymerase II dynamics.
Twisting the theory on the origin of human umbilical cord coiling featuring monozygotic twinsThis study provides a novel framework to understand the molecular origins of human umbilical cord helices using state-of-the-art imaging and omics approaches.
Reversal of high-glucose–induced transcriptional and epigenetic memories through NRF2 pathway activationTransient exposure to high glucose induces enduring transcriptional and chromatin alterations in endothelial cells. Activation of the NRF2 pathway with sulforaphane can mitigate these cellular memories, offering valuable insight into the mechanisms and management of diabetes-associated complications.
Trim66’s paternal deficiency causes intrauterine overgrowthTRIM66 is a PHD-Bromo–containing protein primarily expressed in spermatids. Here, we report a paternal effect phenotype whereby homozygous Trim66-mutant males sired progeny overweight at birth.
The Rtf1/Prf1-dependent histone modification axis counteracts multi-drug resistance in fission yeastMutations in a conserved histone modification axis confer a unique drug-tolerant phenotype in fission yeast, and suggest a mode of gene regulation shared with the Rpb1 C-terminal domain.
Epigenomic states contribute to coordinated allelic transcriptional bursting in iPSC reprogrammingEpigenomic states are linked to the coordinated allelic transcriptional bursting of genes involved in iPSC reprogramming.
Mapping parental DMRs predictive of local and distal methylome remodeling in epigenetic F1 hybridsWe show that parental DNA methylation divergence in pericentromeric regions predicts non-additivity in the methylomes, transcriptomes, and phenotypes of F1 hybrids, independently of DNA sequence divergence.
Spatiotemporal DNA methylation dynamics shape megabase-scale methylome landscapesThe guanine–cytosine content of genomic regions influences their spatial properties, resulting in various megabase-scale methylome patterns across different cell types.