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Chromatin & Epigenetics

  • Inter and transgenerational impact of H3K4 methylation in neuronal homeostasis
    Open Access
    Inter and transgenerational impact of H3K4 methylation in neuronal homeostasis

    Steffen Abay-Nørgaard, Marta Cecylia Tapia, Mandoh Zeijdner, Jeonghwan Henry Kim, Kyoung Jae Won, Bo Porse, Anna Elisabetta Salcini

    Steffen Abay-Nørgaard ... Anna Elisabetta Salcini

    Published 24 May 2023

    The study highlights the importance of maintaining appropriate H3K4me3 levels to prevent negative impacts on nerve system homeostasis across generations.

  • Methylation of lysine 36 on histone H3 is required to control transposon activities in somatic cells
    Open Access
    Methylation of lysine 36 on histone H3 is required to control transposon activities in somatic cells

    Henrik Lindehell, Yuri B Schwartz, Jan Larsson

    Henrik Lindehell ... Jan Larsson

    Published 11 May 2023

    Disruption of H3K36 methylation in somatic cells leads to transposon transcription and activation of key genes in the PIWI-interacting RNA pathway together with RNA production from piRNA clusters.

  • Cohesin SMC1β promotes closed chromatin and controls TERRA expression at spermatocyte telomeres
    Open Access
    Cohesin SMC1β promotes closed chromatin and controls TERRA expression at spermatocyte telomeres

    Uddipta Biswas, Tanaya Deb Mallik, Johannes Pschirer, Matthias Lesche, Katrin Sameith, Rolf Jessberger

    Uddipta Biswas ... Rolf Jessberger

    Published 9 May 2023

    Cohesin SMC1β; ensures silencing at chromosome ends, restricts TERRA expression and RNA-DNA hybrid formation, and prevents telomer damage.

  • BiFCo: visualizing cohesin assembly/disassembly cycle in living cells
    Open Access
    BiFCo: visualizing cohesin assembly/disassembly cycle in living cells

    Emilio González-Martín, Juan Jiménez, Víctor A Tallada

    Emilio González-Martín ... Víctor A Tallada

    Published 9 May 2023

    A novel strategy developed in fission yeast to visualise only-assembled cohesin complex loading/unloading cycles in eukaryotic chromosomes in living cells.

  • BAZ2A-RNA mediated association with TOP2A and KDM1A represses genes implicated in prostate cancer
    Open Access
    BAZ2A-RNA mediated association with TOP2A and KDM1A represses genes implicated in prostate cancer

    Marcin Roganowicz, Dominik Bär, Cristiana Bersaglieri, Rossana Aprigliano, Raffaella Santoro

    Marcin Roganowicz ... Raffaella Santoro

    Published 25 April 2023

    BAZ2A-mediated repression in prostate cancer is regulated by the RNA-binding TAM domain. The BAZ2A-TAM domain, in association with RNA, promotes the interaction with TOP2A and KDM1A that serves to repress genes critical to prostate cancer progression.

  • Dynamic changes of enhancer and super enhancer landscape in degenerated nucleus pulposus cells
    Open Access
    Dynamic changes of enhancer and super enhancer landscape in degenerated nucleus pulposus cells

    Guowang Li, Yuxiang Kang, Xiangling Feng, Guohua Wang, Yue Yuan, Zhenhua Li, Lilong Du, Baoshan Xu

    Guowang Li ... Baoshan Xu

    Published 3 April 2023

    Super-enhancers mediate inflammatory cascade and extracellular matrix remodeling in degenerated nucleus pulposus cells.

  • H4K20me1 plays a dual role in transcriptional regulation of regeneration and axis patterning in <em>Hydra</em>
    Open Access
    H4K20me1 plays a dual role in transcriptional regulation of regeneration and axis patterning in Hydra

    Akhila Gungi, Shagnik Saha, Mrinmoy Pal, Sanjeev Galande

    Akhila Gungi ... Sanjeev Galande

    Published 21 March 2023

    H4K20me1 modification by SETD8 methyltransferase is typically associated with repression. In Hydra, it is associated with activation machinery locally at Wnt-responsive promoters indicating its dual role in transcriptional regulation.

  • The TUDOR domain of SMN is an H3K79<sup>me1</sup> histone mark reader
    Open Access
    The TUDOR domain of SMN is an H3K79me1 histone mark reader

    Olivier Binda, Aimé Boris Kimenyi Ishimwe, Maxime Galloy, Karine Jacquet, Armelle Corpet, Amélie Fradet-Turcotte, Jocelyn Côté, Patrick Lomonte

    Olivier Binda ... Patrick Lomonte

    Published 7 March 2023

    The survival of motor neuron (SMN) protein is depleted in spinal muscular atrophy (SMA) pathology and herein defined as the first reader of histone H3 mono-methylated on lysine 79 through its central TUDOR domain.

  • RAS and PP2A activities converge on epigenetic gene regulation
    Open Access
    RAS and PP2A activities converge on epigenetic gene regulation

    Anna Aakula, Mukund Sharma, Francesco Tabaro, Reetta Nätkin, Jesse Kamila, Henrik Honkanen, Matthieu Schapira, Cheryl Arrowsmith, Matti Nykter, Jukka Westermarck

    Anna Aakula ... Jukka Westermarck

    Published 1 March 2023

    This study reveals a hidden regulatory layer in epigenetic gene expression in cancer by co-operative phosphoregulation by RAS and tumor suppressor phosphatase PP2A.

  • Disruption of polyhomeotic polymerization decreases nucleosome occupancy and alters genome accessibility
    Open Access
    Disruption of polyhomeotic polymerization decreases nucleosome occupancy and alters genome accessibility

    Adfar Amin, Sangram Kadam, Jakub Mieczkowski, Ikhlak Ahmed, Younus A Bhat, Fouziya Shah, Michael Y Tolstorukov, Robert E Kingston, Ranjith Padinhateeri, Ajazul H Wani

    Adfar Amin ... Ajazul H Wani

    Published 27 February 2023

    Disruption of SAM domain–mediated polymerization of Polycomb Group protein polyhomeotic decreases nucleosome occupancy in Drosophila S2 cells.

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