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Chromatin & Epigenetics

  • miR-486 is essential for muscle function and suppresses a dystrophic transcriptome
    Open Access
    miR-486 is essential for muscle function and suppresses a dystrophic transcriptome

    Adrienne Samani, Rylie M Hightower, Andrea L Reid, Katherine G English, Michael A Lopez, J Scott Doyle, Michael J Conklin, David A Schneider, Marcas M Bamman, Jeffrey J Widrick, David K Crossman, Min Xie, David Jee, Eric C Lai, Matthew S Alexander

    Adrienne Samani ... Matthew S Alexander

    Published 5 May 2022

    The authors identify miR-486 as essential for normal muscle function and a driver of dystrophic transcriptomic pathways using mir-486 knockout mice and multiple sequencing platforms.

  • Nutrient sensitive protein <em>O</em>-GlcNAcylation modulates the transcriptome through epigenetic mechanisms during embryonic neurogenesis
    Open Access
    Nutrient sensitive protein O-GlcNAcylation modulates the transcriptome through epigenetic mechanisms during embryonic neurogenesis

    Shama Parween, Thilina T Alawathugoda, Ashok D Prabakaran, S Thameem Dheen, Randall H Morse, Bright Starling Emerald, Suraiya A Ansari

    Shama Parween ... Suraiya A Ansari

    Published 25 April 2022

    Maternal hyperglycemia and elevated O-GlcNAc levels perturb promoter bivalency and lead to transcriptional up-regulation of neurogenic transcription factors during embryonic neurogenesis.

  • TET2-mediated epigenetic reprogramming of breast cancer cells impairs lysosome biogenesis
    Open Access
    TET2-mediated epigenetic reprogramming of breast cancer cells impairs lysosome biogenesis

    Audrey Laurent, Thierry Madigou, Maud Bizot, Marion Turpin, Gaëlle Palierne, Elise Mahé, Sarah Guimard, Raphaël Métivier, Stéphane Avner, Christine Le Péron, Gilles Salbert

    Audrey Laurent ... Gilles Salbert

    Published 29 March 2022

    TET2-mediated oxidation of 5-methylcytosine establishes an antiviral state and contributes to MYC-dependent down-regulation of genes involved in lysosome biogenesis and function in breast cancer cells.

  • Ribosomal protein L5 facilitates rDNA-bundled condensate and nucleolar assembly
    Open Access
    Ribosomal protein L5 facilitates rDNA-bundled condensate and nucleolar assembly

    Haruka Matsumori, Kenji Watanabe, Hiroaki Tachiwana, Tomoko Fujita, Yuma Ito, Makio Tokunaga, Kumiko Sakata-Sogawa, Hiroko Osakada, Tokuko Haraguchi, Akinori Awazu, Hiroshi Ochiai, Yuka Sakata, Koji Ochiai, Tsutomu Toki, Etsuro Ito, Ilya G Goldberg, Kazuaki Tokunaga, Mitsuyoshi Nakao, Noriko Saitoh

    Haruka Matsumori ... Noriko Saitoh

    Published 23 March 2022

    High content image analysis, single molecule tracking, modeling, and DBA patient analysis revealed that ribosomal protein L5 facilitates rDNA-bundled condensate and nucleolar assembly.

  • DNA methylation–independent long-term epigenetic silencing with dCRISPR/Cas9 fusion proteins
    Open Access
    DNA methylation–independent long-term epigenetic silencing with dCRISPR/Cas9 fusion proteins

    Li Ding, Lukas Theo Schmitt, Melanie Brux, Duran Sürün, Martina Augsburg, Felix Lansing, Jovan Mircetic, Mirko Theis, Frank Buchholz

    Li Ding ... Frank Buchholz

    Published 14 March 2022

    Long-term epigenetic gene silencing can be induced independently of DNA methylation by dCas9-KRABd-MeCP2 fusion proteins.

  • AGO1 regulates pericentromeric regions in mouse embryonic stem cells
    Open Access
    AGO1 regulates pericentromeric regions in mouse embryonic stem cells

    Madlen Müller, Tara Fäh, Moritz Schaefer, Victoria Hermes, Janina Luitz, Patrick Stalder, Rajika Arora, Richard Patryk Ngondo, Constance Ciaudo

    Madlen Müller ... Constance Ciaudo

    Published 2 March 2022

    Depletion of AGO1 in mESCs leads to a redistribution of H3K9me3 and HP1α away from pericentromeric regions and is accompanied by an up-regulation of major satellites transcripts.

  • Angioplasty induces epigenomic remodeling in injured arteries
    Open Access
    Angioplasty induces epigenomic remodeling in injured arteries

    Mengxue Zhang, Go Urabe, Hatice Gulcin Ozer, Xiujie Xie, Amy Webb, Takuro Shirasu, Jing Li, Renzhi Han, K Craig Kent, Bowen Wang, Lian-Wang Guo

    Mengxue Zhang ... Lian-Wang Guo

    Published 15 February 2022

    This is the first in vivo epigenomic survey revealing genome-wide loci-specific chromatin mark redistribution after angioplasty; the underlying epigenetic regulations may inform therapeutic targeting.

  • Refining the domain architecture model of the replication origin firing factor Treslin/TICRR
    Open Access
    Refining the domain architecture model of the replication origin firing factor Treslin/TICRR

    Pedro Ferreira, Luis Sanchez-Pulido, Anika Marko, Chris P Ponting, Dominik Boos

    Pedro Ferreira ... Dominik Boos

    Published 28 January 2022

    The replication origin firing factor Treslin/TICRR comprises an essential Sld3-like core that requires the flanking Ku70-like N-terminal and the C-terminal domains for efficient origin firing.

  • Cis-regulatory hubs: a new 3D model of complex disease genetics with an application to schizophrenia
    Open Access
    Cis-regulatory hubs: a new 3D model of complex disease genetics with an application to schizophrenia

    Loïc Mangnier, Charles Joly-Beauparlant, Arnaud Droit, Steve Bilodeau, Alexandre Bureau

    Loïc Mangnier ... Alexandre Bureau

    Published 27 January 2022

    Genes and their regulatory elements are organized in neurons within 3D networks which model functional structures and explain schizophrenia genetic etiology.

  • Recruitment of Scc2/4 to double-strand breaks depends on γH2A and DNA end resection
    Open Access
    Recruitment of Scc2/4 to double-strand breaks depends on γH2A and DNA end resection

    Martin Scherzer, Fosco Giordano, Maria Solé Ferran, Lena Ström

    Martin Scherzer ... Lena Ström

    Published 27 January 2022

    DSB recruitment of the cohesin loader Scc2/4 relies on Tel1 and γH2A, but contrary to cohesin not on Mec1; binding emanates from the break site and depends on as well as coincides with end resection.

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