Chromatin & Epigenetics
CSDE1 controls gene expression through the miRNA-mediated decay machineryCSDE1 is a new component of miRNA-induced silencing complex and interacts with DCP1–DCP2 decapping machinery with potential roles in miRNA-mediated target degradation.
Splicing of enhancer-associated lincRNAs contributes to enhancer activityAnalysis of enhancer-associated lincRNA transcripts shows their efficient and conserved splicing contributes to cognate enhancer activity and cis-regulation of target gene expression.
Meiotic sex chromosome cohesion and autosomal synapsis are supported by Esco2This study reveals a role for the cohesin modifier ESCO2 for maintenance of sister chromatid cohesion in mammalian meiosis and a specific weakness of cohesion within male sex chromosome chromatin
Nup93 regulates breast tumor growth by modulating cell proliferation and actin cytoskeleton remodelingThis study highlights the role of Nup93-chromatin interactions in driving triple-negative breast cancer propagation through modulation of the actin cytoskeleton, cell migration and proliferation.
Oscillatory cAMP signaling rapidly alters H3K4 methylationThis work explores how GPCR-cAMP signaling dynamically influences histone methylation by altering intracellular labile Fe(II) levels and subsequently modulating histone demethylase activity.
Drug-induced chromatin accessibility changes associate with sensitivity to liver tumor promotionThis work explores quantitative chromatin accessibility, transcriptional and cis-acting gene regulatory variations underlying mouse strain–specific differences in drug-induced liver tumor promotion sensitivity.
Endogenous epitope-tagging of Tet1, Tet2 and Tet3 identifies TET2 as a naïve pluripotency markerExpression of TET proteins in pluripotent cell types is visualised by epitope tagging of endogenous alleles.
Subunit interactions and arrangements in the fission yeast Mis16–Mis18–Mis19 complexA structural study of the fission yeast Mis19 protein, required for centromere establishment, is presented together with data describing its interactions with functional partners Mis16 and Mis18.
Molecular characterization of Chlamydomonas reinhardtii telomeres and telomerase mutantsThis study characterizes the sequence, end structure, and length distribution of Chlamydomonas reinhardtii telomeres and shows that telomerase mutants are defective in telomere maintenance.
Mitotic replisome disassembly depends on TRAIP ubiquitin ligase activityAnalysis of the mitotic replisome disassembly pathway in X. laevis egg extract shows that any replisomes retained on chromatin past S-phase are unloaded through formation of K6- and K63-linked ubiquitin chains on Mcm7 by TRAIP ubiquitin ligase and p97/VCP activity.