Chromatin & Epigenetics
Distinct mechanisms mediate X chromosome dosage compensation in Anopheles and DrosophilaCRISPR knockout of msl-2 and epigenome analyses in Anopheles reveal that X chromosome dosage compensation in mosquitos and Drosophila is achieved by two different molecular mechanisms.
Hierarchical dinucleotide distribution in genome along evolution and its effect on chromatin packingIt describes how hierarchical CpG distribution on the genomes of species change in the evolution and the correlation with the chromatin structure.
A role for condensin in mediating transcriptional adaptation to environmental stimuliFast conditional depletion of the chromosomal condensin complex from budding yeast cells reveals roles in transcriptional regulation, especially during the establishment of new gene expression patterns.
Gametic specialization of centromeric histone paralogs in Drosophila virilisSomatic and germline centromeric functions could differ because of different chromatin environments in male and female gametes versus somatic cells. We show that two different centromeric histone paralogs are alternately retained in male versus female gametes in many Drosophila species.
In utero exposure to chlordecone affects histone modifications and activates LINE-1 in cord bloodIn utero exposure to chlordecone affects chromatin and leads to activation of retroelements. This study shows the changes induced by chlordecone in human umbilical cord blood and blood-derived cell line.
Replicated chromatin curtails 53BP1 recruitment in BRCA1-proficient and BRCA1-deficient cellsThis study demonstrates how single cell normalization to genome size provides insight into genome function, here in the context of DNA double-strand break repair by 53BP1 versus BRCA1–BARD1.
RNA polymerase backtracking results in the accumulation of fission yeast condensin at active genesUsing both experiments and mathematical modelling, the authors show that RNA polymerase backtracking contributes to the accumulation of condensin in the termination zone of active genes.
Structural basis of nucleosomal histone H4 lysine 20 methylation by SET8 methyltransferaseCryo-EM structures of the human SET8–nucleosome complexes reveal the mechanism by which the SET8 methyltransferase binds the nucleosome and specifically recognizes the histone H4 lysine-20 residue.
Different mutant RUNX1 oncoproteins program alternate haematopoietic differentiation trajectoriesUsing integrated genome-wide and phenotypic methods this study investigates four different mutant RUNX1 oncoproteins and reveals how they differentially contribute to aberrant haematopoiesis.
The uncharacterized protein FAM47E interacts with PRMT5 and regulates its functionsThe uncharacterized protein FAM47E interacts with and stabilizes the protein arginine methyltransferase PRMT5, regulating its epigenetic functions thereby modulating target gene expression.