Chromatin & Epigenetics
Differential modulation of polycomb-associated histone marks by cBAF, pBAF, and gBAF complexesThis study shows that the canonical BAF (cBAF) complex uniquely opposes polycomb-associated repressive marks at the Nkx2-9 gene in mouse embryonic stem cells, leading to transcriptional activation, a function not shared by gBAF or pBAF complexes.
Defective Integrator activity shapes the transcriptome of patients with multiple sclerosisHigh-depth RNA sequencing reveals down-regulation of HP1α/CBX5 in monocytes of multiple sclerosis patients, associated with major transcriptomic changes and reduced activity of the Integrator complex.
Cellular zinc status alters chromatin accessibility and binding of p53 to DNAATAC-seq and transcription factor enrichment analysis reveal that perturbations in labile Zn2+ alter chromatin accessibility and enrichment of transcription factor motifs in regions of open chromatin.
p53 ensures the normal behavior and modification of G1/S-specific histone H3.1 in the nucleusp53 down-regulates nuclear phosphatidic acid levels to avoid the aberrant accumulation and modification of histone H3.1 during the G1/S phase, in which p53-mediated induction of a specific gene is the initial step.
The type of DNA damage response after decitabine treatment depends on the level of DNMT activityChromatin-centred proteomics study in stem cells with different DNMT expression levels and activities reveals that decitabine invokes different DNA damage responses depending on the amount of the induced DNA-DNMT crosslinks.
Single-housing–induced islet epigenomic changes are related to polymorphisms in diabetic KK miceThis study demonstrates that non-coding variants in KK mice, a polygenic model of type 2 diabetes, may be involved in the development of diabetes via epigenetic mechanisms during social isolation.
The importance of DNA sequence for nucleosome positioning in transcriptional regulationMachine learning on DNA sequences shows that nucleosomes are positioned by DNA sequence patterns to support the stages of transcription by directing competition between nucleosomes and transcription factors, as well as regulating RNA polymerase II dynamics.
Twisting the theory on the origin of human umbilical cord coiling featuring monozygotic twinsThis study provides a novel framework to understand the molecular origins of human umbilical cord helices using state-of-the-art imaging and omics approaches.
Reversal of high-glucose–induced transcriptional and epigenetic memories through NRF2 pathway activationTransient exposure to high glucose induces enduring transcriptional and chromatin alterations in endothelial cells. Activation of the NRF2 pathway with sulforaphane can mitigate these cellular memories, offering valuable insight into the mechanisms and management of diabetes-associated complications.
Trim66’s paternal deficiency causes intrauterine overgrowthTRIM66 is a PHD-Bromo–containing protein primarily expressed in spermatids. Here, we report a paternal effect phenotype whereby homozygous Trim66-mutant males sired progeny overweight at birth.