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Chromatin & Epigenetics

  • Structural basis of nucleosomal histone H4 lysine 20 methylation by SET8 methyltransferase
    Open Access
    Structural basis of nucleosomal histone H4 lysine 20 methylation by SET8 methyltransferase

    Cheng-Han Ho, Yoshimasa Takizawa, Wataru Kobayashi, Yasuhiro Arimura, Hiroshi Kimura, Hitoshi Kurumizaka

    Cheng-Han Ho ... Hitoshi Kurumizaka

    Published 11 February 2021

    Cryo-EM structures of the human SET8–nucleosome complexes reveal the mechanism by which the SET8 methyltransferase binds the nucleosome and specifically recognizes the histone H4 lysine-20 residue.

  • Different mutant RUNX1 oncoproteins program alternate haematopoietic differentiation trajectories
    Open Access
    Different mutant RUNX1 oncoproteins program alternate haematopoietic differentiation trajectories

    Sophie G Kellaway, Peter Keane, Benjamin Edginton-White, Kakkad Regha, Ella Kennett, Constanze Bonifer

    Sophie G Kellaway ... Constanze Bonifer

    Published 4 January 2021

    Using integrated genome-wide and phenotypic methods this study investigates four different mutant RUNX1 oncoproteins and reveals how they differentially contribute to aberrant haematopoiesis.

  • The uncharacterized protein FAM47E interacts with PRMT5 and regulates its functions
    Open Access
    The uncharacterized protein FAM47E interacts with PRMT5 and regulates its functions

    Baskar Chakrapani, Mohd Imran K Khan, Rajashekar Varma Kadumuri, Somlee Gupta, Mamta Verma, Sharad Awasthi, Gayathri Govindaraju, Arun Mahesh, Arumugam Rajavelu, Sreenivas Chavali, Arunkumar Dhayalan

    Baskar Chakrapani ... Arunkumar Dhayalan

    Published 29 December 2020

    The uncharacterized protein FAM47E interacts with and stabilizes the protein arginine methyltransferase PRMT5, regulating its epigenetic functions thereby modulating target gene expression.

  • The chromatin landscape of primary synovial sarcoma organoids is linked to specific epigenetic mechanisms and dependencies
    Open Access
    The chromatin landscape of primary synovial sarcoma organoids is linked to specific epigenetic mechanisms and dependencies

    Gaylor Boulay, Luisa Cironi, Sara P Garcia, Shruthi Rengarajan, Yu-Hang Xing, Lukuo Lee, Mary E Awad, Beverly Naigles, Sowmya Iyer, Liliane C Broye, Tugba Keskin, Alexandra Cauderay, Carlo Fusco, Igor Letovanec, Ivan Chebib, Petur Gunnalugur Nielsen, Stéphane Tercier, Stéphane Cherix, Tu Nguyen-Ngoc, Gregory Cote, Edwin Choy, Paolo Provero, Mario L Suvà, Miguel N Rivera, Ivan Stamenkovic, Nicolò Riggi

    Gaylor Boulay ... Nicolò Riggi

    Published 23 December 2020

    We have addressed the mechanisms by which the fusion protein SS18-SSX modifies the epigenome toward the development of synovial sarcoma and the establishment of its potentially targetable vulnerabilities.

  • Polycomb mutant partially suppresses DNA hypomethylation–associated phenotypes in Arabidopsis
    Open Access
    Polycomb mutant partially suppresses DNA hypomethylation–associated phenotypes in Arabidopsis

    Martin Rougée, Leandro Quadrana, Jérôme Zervudacki, Valentin Hure, Vincent Colot, Lionel Navarro, Angélique Deleris

    Martin Rougée ... Angélique Deleris

    Published 21 December 2020

    A mutation in Arabidopsis polycomb repressive complex 2 partially suppresses the transposon activity observed in a DNA methylation mutant, challenging expectations.

  • Mps2 links Csm4 and Mps3 to form a telomere-associated LINC complex in budding yeast
    Open Access
    Mps2 links Csm4 and Mps3 to form a telomere-associated LINC complex in budding yeast

    Jinbo Fan, Hui Jin, Bailey A Koch, Hong-Guo Yu

    Jinbo Fan ... Hong-Guo Yu

    Published 23 September 2020

    The canonical LINC complex is composed of two different transmembrane proteins; this work reveals the heterotrimeric composition of the telomere-associated LINC complex in budding yeast.

  • Stoichiometry of Rtt109 complexes with Vps75 and histones H3-H4
    Open Access
    Stoichiometry of Rtt109 complexes with Vps75 and histones H3-H4

    Noushin Akhavantabib, Daniel D Krzizike, Victoria Neumann, Sheena D’Arcy

    Noushin Akhavantabib ... Sheena D’Arcy

    Published 10 September 2020

    The work determines the relative and absolute stoichiometry of a 5-chain protein complex involved in histone chaperoning and acetylation. Using sedimentation velocity and light scattering, it uncovers a dynamic equilibrium of complex self-association.

  • Biochemical and functional characterization of a meiosis-specific Pch2/ORC AAA+ assembly
    Open Access
    Biochemical and functional characterization of a meiosis-specific Pch2/ORC AAA+ assembly

    María Ascensión Villar-Fernández, Richard Cardoso da Silva, Magdalena Firlej, Dongqing Pan, Elisabeth Weir, Annika Sarembe, Vivek B Raina, Tanja Bange, John R Weir, Gerben Vader

    María Ascensión Villar-Fernández ... Gerben Vader

    Published 21 August 2020

    The AAA+ protein Pch2 forms a biochemical complex with Orc1/ORC to suppress DNA break formation in the meiotic G2/prophase.

  • CSDE1 controls gene expression through the miRNA-mediated decay machinery
    Open Access
    CSDE1 controls gene expression through the miRNA-mediated decay machinery

    Pavan Kumar Kakumani, Louis-Mathieu Harvey, François Houle, Tanit Guitart, Fátima Gebauer, Martin J Simard

    Pavan Kumar Kakumani ... Martin J Simard

    Published 11 March 2020

    CSDE1 is a new component of miRNA-induced silencing complex and interacts with DCP1–DCP2 decapping machinery with potential roles in miRNA-mediated target degradation.

  • Splicing of enhancer-associated lincRNAs contributes to enhancer activity
    Open Access
    Splicing of enhancer-associated lincRNAs contributes to enhancer activity

    Jennifer Y Tan, Adriano Biasini, Robert S Young, Ana C Marques

    Jennifer Y Tan ... Ana C Marques

    Published 21 February 2020

    Analysis of enhancer-associated lincRNA transcripts shows their efficient and conserved splicing contributes to cognate enhancer activity and cis-regulation of target gene expression.

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