Chromatin & Epigenetics
Inter and transgenerational impact of H3K4 methylation in neuronal homeostasisThe study highlights the importance of maintaining appropriate H3K4me3 levels to prevent negative impacts on nerve system homeostasis across generations.
Methylation of lysine 36 on histone H3 is required to control transposon activities in somatic cellsDisruption of H3K36 methylation in somatic cells leads to transposon transcription and activation of key genes in the PIWI-interacting RNA pathway together with RNA production from piRNA clusters.
Cohesin SMC1β promotes closed chromatin and controls TERRA expression at spermatocyte telomeresCohesin SMC1β; ensures silencing at chromosome ends, restricts TERRA expression and RNA-DNA hybrid formation, and prevents telomer damage.
BiFCo: visualizing cohesin assembly/disassembly cycle in living cellsA novel strategy developed in fission yeast to visualise only-assembled cohesin complex loading/unloading cycles in eukaryotic chromosomes in living cells.
BAZ2A-RNA mediated association with TOP2A and KDM1A represses genes implicated in prostate cancerBAZ2A-mediated repression in prostate cancer is regulated by the RNA-binding TAM domain. The BAZ2A-TAM domain, in association with RNA, promotes the interaction with TOP2A and KDM1A that serves to repress genes critical to prostate cancer progression.
Dynamic changes of enhancer and super enhancer landscape in degenerated nucleus pulposus cellsSuper-enhancers mediate inflammatory cascade and extracellular matrix remodeling in degenerated nucleus pulposus cells.
H4K20me1 plays a dual role in transcriptional regulation of regeneration and axis patterning in HydraH4K20me1 modification by SETD8 methyltransferase is typically associated with repression. In Hydra, it is associated with activation machinery locally at Wnt-responsive promoters indicating its dual role in transcriptional regulation.
The TUDOR domain of SMN is an H3K79me1 histone mark readerThe survival of motor neuron (SMN) protein is depleted in spinal muscular atrophy (SMA) pathology and herein defined as the first reader of histone H3 mono-methylated on lysine 79 through its central TUDOR domain.
RAS and PP2A activities converge on epigenetic gene regulationThis study reveals a hidden regulatory layer in epigenetic gene expression in cancer by co-operative phosphoregulation by RAS and tumor suppressor phosphatase PP2A.
Disruption of polyhomeotic polymerization decreases nucleosome occupancy and alters genome accessibilityDisruption of SAM domain–mediated polymerization of Polycomb Group protein polyhomeotic decreases nucleosome occupancy in Drosophila S2 cells.