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Chemical Biology

  • Human DNA polymerase delta is a pentameric holoenzyme with a dimeric p12 subunit
    Open Access
    Human DNA polymerase delta is a pentameric holoenzyme with a dimeric p12 subunit

    Prashant Khandagale, Doureradjou Peroumal, Kodavati Manohar, Narottam Acharya

    Prashant Khandagale ... Narottam Acharya

    Published 18 March 2019

    The subunit p12 of human DNA polymerase delta (hPolδ) can dimerize, facilitating its interaction with PCNA and suggesting that hPolδ exists in a pentameric form in the cell.

  • Chemical genetic identification of GAK substrates reveals its role in regulating Na<sup>+</sup>/K<sup>+</sup>-ATPase
    Open Access
    Chemical genetic identification of GAK substrates reveals its role in regulating Na+/K+-ATPase

    Amy W Lin, Kalbinder K Gill, Marisol Sampedro Castañeda, Irene Matucci, Noreen Eder, Suzanne Claxton, Helen Flynn, Ambrosius P Snijders, Roger George, Sila K Ultanir

    Amy W Lin ... Sila K Ultanir

    Published 31 December 2018

    Novel GAK phosphorylation targets are identified using chemical genetic methods. One of the substrates is the α subunit of the Na+/K+-ATPase, phosphorylation of which is necessary for its surface trafficking from endosomes. Conserved functions of NAK family kinases are described.

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