Cell Biology
- A new ferrocene derivative blocks K-Ras localization and function by oxidative modification at His95
We report redox system regulates KRAS localization and activity via oxidation at His95 residue, and proposes a role of oncogenic K-Ras in the antioxidant-induced growth and metastasis of KRAS-driven cancers.
- LEF1 enhances β-catenin transactivation through IDR-dependent liquid–liquid phase separation
This research elucidates the correlation between liquid–liquid phase separation (LLPS) of LEF1 with β-catenin and their transcriptional activation function, offering a novel therapeutic approach for the treatment of colorectal cancer through LLPS.
- Polo-like kinase-1 mediates hepatitis C virus-induced cell migration, a drug target for liver cancer
This study identifies PLK1 as a novel protein that promotes liver cancer in people with hepatitis C. The findings suggest a novel drug target for patients with liver cancer to reduce cancer spread and improve survival.
- Convergent evolution and B-cell recirculation in germinal centers in a human lymph node
The study characterizes an ongoing immune response by sequencing B-cells from 10 germinal centers and finds diverse clonal patterns and convergent evolution, indicating re-engagement and rediversification of B-cell clones across GCs.
- p62 and NBR1 functions are dispensable for aggrephagy in mouse ESCs and ESC-derived neurons
This work shows a robust and stable aggrephagy regulation in mouse ESCs and ESC-derived neurons in absence of p62 and NBR1 functions.
- Tumor necrosis factor mediates USE1-independent FAT10ylation under inflammatory conditions
The finding of TNF-dependent FAT10ylation in the absence of USE1 identifies seven additional, so far unknown FAT10-reactive E2 conjugating enzymes.
- Structural evidence for elastic tethers connecting separating chromosomes in crane-fly spermatocytes
Correlative live imaging with electron tomography provides evidence that physical filamentous connections extend between separating telomeres at all stages of anaphase.
- A Msp1-containing complex removes orphaned proteins in the mitochondrial outer membrane of T. brucei
Disruption of mitochondrial outer membrane protein biogenesis triggers a pathway leading to proteasomal degradation of orphan outer membrane proteins mediated by Msp1 and three interacting proteins.
- High-resolution kinetic characterization of the RIG-I-signaling pathway and the antiviral response
This study takes a comprehensive approach to understand the dynamics of the cell-intrinsic response towards virus infection and how viruses actively modulate this.
- Caspase-4 dimerisation and D289 auto-processing elicit an interleukin-1β-converting enzyme
The noncanonical inflammasome generates p32/p9 and p34/p9 active caspase-4 species via dimerisation and autocleavage; both species cleave GSDMD to induce pyroptosis, whereas p34/p9 matures IL-1β.