Cell Biology
- KIF16B drives MT1-MMP recycling in macrophages and promotes co-invasion of cancer cells
Recycling of the metalloproteinase MT1-MMP by the motor KIF16B regulates 3D invasion of macrophages, and also co-invasion of cancer cells, pointing to a role of KIF16B in the tumor microenvironment.
- Control of Paneth cell function by HuR regulates gut mucosal growth by altering stem cell activity
HuR stimulates the activity of intestinal stem cells by enhancing Paneth cell function via activation of mitochondrial metabolism, thus promoting renewal of the intestinal mucosa.
- Mitochondrial membrane potential acts as a retrograde signal to regulate cell cycle progression
This study finds that decreases in mitochondrial membrane potential serve as a means of mito-cellular signalling to delay the transition of yeast cells from the G1 to the S phase of the cell cycle.
- Loss of the mitochondrial protein SPD-3 elevates PLK-1 levels and dysregulates mitotic events
In C. elegans a mutation in the mitochondria-localized protein SPD-3 leads to elevated levels of Polo-like kinase 1, causing abnormal chromosome positioning during mitosis.
- VDR is an essential regulator of hair follicle regression through the progression of cell death
This study investigates the role of VDR in the progression of catagen, and demonstrates that aberrant regression that ectopically prevents cell death impairs hair follicle regeneration, emphasizing the significance of regression in tissue homeostasis.
- A new ferrocene derivative blocks K-Ras localization and function by oxidative modification at His95
We report redox system regulates KRAS localization and activity via oxidation at His95 residue, and proposes a role of oncogenic K-Ras in the antioxidant-induced growth and metastasis of KRAS-driven cancers.
- LEF1 enhances β-catenin transactivation through IDR-dependent liquid–liquid phase separation
This research elucidates the correlation between liquid–liquid phase separation (LLPS) of LEF1 with β-catenin and their transcriptional activation function, offering a novel therapeutic approach for the treatment of colorectal cancer through LLPS.
- Polo-like kinase-1 mediates hepatitis C virus-induced cell migration, a drug target for liver cancer
This study identifies PLK1 as a novel protein that promotes liver cancer in people with hepatitis C. The findings suggest a novel drug target for patients with liver cancer to reduce cancer spread and improve survival.
- Convergent evolution and B-cell recirculation in germinal centers in a human lymph node
The study characterizes an ongoing immune response by sequencing B-cells from 10 germinal centers and finds diverse clonal patterns and convergent evolution, indicating re-engagement and rediversification of B-cell clones across GCs.
- p62 and NBR1 functions are dispensable for aggrephagy in mouse ESCs and ESC-derived neurons
This work shows a robust and stable aggrephagy regulation in mouse ESCs and ESC-derived neurons in absence of p62 and NBR1 functions.