Cell Biology
Neuronal Aβ42 is enriched in small vesicles at the presynaptic side of synapsesSuper-resolution microscopy reveals that Aβ42 is mainly present at the presynaptic side of the synapse.
ERα activity depends on interaction and target site corecruitment with phosphorylated CREB1CREB1 interacts with, stimulates, and is necessary for estrogen receptor α activation by estrogen or cAMP signaling, and this cooperation may underlie their anti-apoptotic activities in breast cancer cells.
Multiple membrane extrusion sites drive megakaryocyte migration into bone marrow blood vesselsMegakaryocytes enter bone marrow sinusoids to generate platelets by extrusion of internal membrane into the plasma membrane at fusion sites rather than microtubule-driven proplatelet extension.
Serine catabolism is essential to maintain mitochondrial respiration in mammalian cellsMitochondrial respiratory complex assembly requires the one-carbon unit generated from serine catabolism.
Proteomics and C9orf72 neuropathology identify ribosomes as poly-GR/PR interactors driving toxicityProteomics and neuropathological validation show that aberrant poly-GR/PR proteins in C9orf72 ALS/FTD bind STAU2 and ribosomes and inhibit translation.
Regulation of microtubule dynamic instability by the carboxy-terminal tail of β-tubulinThis work examines how the carboxy-terminal tail domain of β-tubulin governs microtubule dynamic instability and the structure of plus ends using complementary in vivo and in vitro experiments.
β-Tubulin carboxy-terminal tails exhibit isotype-specific effects on microtubule dynamics in human gene-edited cellsThis study used human gene-edited cell models and image analysis to reveal that the tubulin C-terminal tails specifically regulate the dynamics of individual microtubules and coordinate microtubule behavior across the cell.
The ER morphology-regulating lunapark protein induces the formation of stacked bilayer discsLunapark, an ER protein implicated in stabilizing junctions of the tubular network and regulating morphology changes during mitosis, forms stacked bilayer discs upon reconstitution with phospholipids.