Cell Biology
Kinesin-8B controls basal body function and flagellum formation and is key to malaria transmissionThis comprehensive study describes the key role and real-time dynamics of Plasmodium kinesin-8B in microtubule-based basal body and axoneme assembly during flagellum (male gamete) formation and parasite transmission.
Vinculin is critical for the robustness of the epithelial cell sheet paracellular barrier for ionsVinculin in the apical junctional complex maintains the paracellular barrier function specifically for ions, but not for large solutes, by buffering mechanical fluctuations.
XIAP controls RIPK2 signaling by preventing its deposition in speck-like structuresThis study provides evidence that the NOD1/2-associated kinase RIPK2 localizes to detergent insoluble cytosolic complexes upon activation and suggests novel regulatory mechanisms for RIPK2 signaling.
The early-acting glycosome biogenic protein Pex3 is essential for trypanosome viabilityThis study reports the identification of trypanosome Pex3, the master regulator of glycosome biogenesis. Trypanosome Pex3 is essential for glycosome assembly and trypanosome viability and is distinct from human Pex3.
Fibril-induced glutamine-/asparagine-rich prions recruit stress granule proteins in mammalian cellsThis study provides evidence that exogenous proteinaceous seeds can induce protein aggregates that sequester stress granule components independent of stress granule assembly.
Inhibition of host NOX1 blocks tumor growth and enhances checkpoint inhibitor–based immunotherapyBlocking NOX1 with the novel small molecule inhibitor GKT771 inhibits tumor growth in mice by targeting tumor lymph/angiogenesis and promoting antitumor immune cells recruitment. GKT771 emerges as a novel and promising anticancer drug worth translating into the clinics.
Tamoxifen blocks retrograde trafficking of Shiga toxin 1 and 2 and protects against lethal toxicosisThis study reports an unexpected role of late endosome–lysosome fusion in early endosome-to-Golgi trafficking of Shiga toxins and identifies tamoxifen to be a potent inhibitor of Shiga toxicosis.
Fibro-adipogenic progenitors of dystrophic mice are insensitive to NOTCH regulation of adipogenesisThe NOTCH pathway, in concert with TNFa, restrains adipogenesis of muscle fibro-adipogenic progenitors (FAPs). Dystrophin-deficient FAPs are less sensitive to NOTCH anti-adipogenic signals, thus explaining why fat infiltrations are solely observed in the muscles of dystrophic individuals.
The WT1–BASP1 complex is required to maintain the differentiated state of taste receptor cellsThe WT1/BASP1 complex is important to maintain taste receptor cells in their terminally differentiated state.
Opposing functions of F-BAR proteins in neuronal membrane protrusion, tubule formation, and neurite outgrowthNeurite formation is a fundamental antecedent to axon and dendrite formation, but the mechanisms that underlie this important process are poorly characterized. Here, we demonstrate that two F-BAR proteins, CIP4 and FBP17, have opposing functions in early cortical neuron development.