Cell Biology
Mitochondrial Aurora kinase A induces mitophagy by interacting with MAP1LC3 and Prohibitin 2The multifunctional Ser/Thr kinase AURKA uses the Inner Mitochondrial Membrane receptor PHB2 and MAP1LC3 as a signalling platform to orchestrate the elimination of dysfunctional mitochondria.
Replicated chromatin curtails 53BP1 recruitment in BRCA1-proficient and BRCA1-deficient cellsThis study demonstrates how single cell normalization to genome size provides insight into genome function, here in the context of DNA double-strand break repair by 53BP1 versus BRCA1–BARD1.
The AXL-PYK2-PKCα axis as a nexus of stemness circuits in TNBCA clinically relevant AXL-PYK2-PKCα axis where PYK2 and PKCα act as signaling nodes and functionally cooperate to converge stemness promoting pathways and regulate Oct4 and Nanog pluripotent TFs.
Cancer-associated cells release citrate to support tumour metastatic progressionCancer-associated stroma is recruited by cancer cells to synthesise and release citrate necessary to support metastatic progression of the disease.
LRRK2-phosphorylated Rab10 sequesters Myosin Va with RILPL2 during ciliogenesis blockadePathogenic LRRK2 phosphorylation of Rab10 GTPase dramatically redistributes Myosin Va and RILPL2 proteins to the mother centriole and sequesters Myosin Va at that location in a manner that likely interferes with its role in ciliogenesis.
Dendritic cell entry to lymphatic capillaries is orchestrated by CD44 and the hyaluronan glycocalyxCD44 anchors the hyaluronan glycocalyx on migrating dendritic cells to permit docking to the endothelial receptor LYVE-1, thus orchestrating lymphatic trafficking through modulating glycocalyx density.
Arterial stiffness and cardiac dysfunction in Hutchinson–Gilford Progeria Syndrome corrected by inhibition of lysyl oxidaseThe findings show that increased lysyl oxidase abundance is causal for the elevated arterial stiffness present in the arteries of Hutchinson–Gilford Progeria Syndrome mice. Pharmacologic inhibition of lysyl oxidase improves cardiac dysfunction and restores arterial compliance.
Comparative profiling of stress granule clearance reveals differential contributions of the ubiquitin systemThis study shows that ubiquitin conjugates associate with various types of stress granules and that an active ubiquitin system is required for the efficient clearance of some types of stress granules.
Kalirin-RAC controls nucleokinetic migration in ADRN-type neuroblastomaVideo and gene expression analyses coupled with the RNAi technique reveal microtubule-dependent, neuronal-like nucleokinetic migration in a noradrenergic type of neuroblastoma, providing a glimpse into the mechanism by which noradrenergic neuroblastoma cells may spread.
nNOS regulates ciliated cell polarity, ciliary beat frequency, and directional flow in mouse tracheaDirectional flow of mucus across the mucociliary epithelium enables the clearance of the airway. This study shows that nNOS supports the flow by regulating the planar polarity and ciliary beat frequency of ciliated cells in the tracheal epithelium.